Enhancement of fentanyl antinociception by subeffective doses of nitroparacetamol (NCX-701) in acute nociception and in carrageenan-induced monoarthritis

Life Sciences

Volumn 77, Issue 1, 2005, Pages 85-95

  Gaitán, Gema ^a   Ahuir, F Javier ^a   Herrero, Juan F ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Analgesia; Nitric oxide; Non steroidal anti inflammatory drugs; Opioids; Pain; Spinal cord; Wind up

Indexed keywords

ANTINOCICEPTIVE AGENT; CARRAGEENAN; FENTANYL; NALOXONE; NCX 701; NITROPARACETAMOL; OPIATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BEHAVIOR; COMPARATIVE STUDY; CONTROLLED STUDY; DOSE RESPONSE; DRUG TOLERABILITY; HYPERALGESIA; MALE; MONARTHRITIS; NONHUMAN; RAT; REFLEX; SENSITIZATION;

EID: 17444421171     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.12.022     Document Type: Article

References (19)

1. V. Bosek, and R. Miguel Comparison of morphine and ketorolac for intravenous patient-controlled analgesia in postoperative cancer patients Clin. J. Pain 10 1994 314 318
2. J.W. Burns, H.A. Aitken, R.E. Bullingham, C.S. McArdle, and G.N. Kenny Double-blind comparison of the morphine sparing effect of continuous and intermittent i.m. administration of ketorolac Br. J. Anaesth. 67 1991 235 238
3. B.L. Carter, S.T. Tiffany, and C.A. Conklin Associative and non-associative fentanyl tolerance in the rat: evaluation of cross tolerance with mu-and kappa-specific opioids Psychopharmacology 148 2000 384 392
4. E. Celerier, J. Laulin, A. Larcher, M. Le Moal, and G. Simonnet Evidence for opiate-activated NMDA processes masking opiate analgesia in rats Brain Res. 847 1 1999 18 25
5. G. Gaitan, and J.F. Herrero Subeffective doses of dexketoprofen trometamol enhance the potency and duration of fentanyl antinociception Br. J. Pharmacol. 135 2002 393 398
6. G. Gaitan, E.A. Romero-Sandoval, and J.F. Herrero The antinociceptive activity of Nitroparacetamol (NCX-701) is located in the spinal cord and increases the potency and duration of the mu-opiate fentanyl antinociception 33rd Annual Meeting, Society for Neuroscience, New Orleans 2003
7. G.W. Gillies, G.N. Kenny, R.E. Bullingham, and C.S. McArdle The morphine sparing effect of ketorolac tromethamine. A study of a new, parenteral non-steroidal anti-inflammatory agent after abdominal surgery Anesthesia 42 1987 727 731
8. J.F. Herrero, and P.M. Headley The effects of sham and full spinalization on the systemic potency of μ- and k-opioids on spinal nociceptive reflexes in rats Br. J. Pharmacol. 104 1991 166 170
9. J.F. Herrero, and R.E. Solano The antinociceptive effect of the μ-opioid fentanyl is reduced in the presence of the α(2)-adrenergic antagonist idazoxan in inflammation Brain Res. 840 1999 106 114
10. J.F. Herrero, J.M.A. Laird, and J.A. Lopez-Garcia Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog. Neurobiol. 61 2000 169 203
11. J. Laitinen, and L. Nuutinen Intravenous diclofenac coupled with PCA fentanyl for pain relief after total hip replacement Anesthesiology 76 1992 194 198
12. J.M. Lashbrook, M.H. Ossipov, J.C. Hunter, R.B. Raffa, R.J. Tallarida, and F. Porreca Synergistic antiallodynic effects of spinal morphine with ketorolac and selective COX1- and COX2-inhibitors in nerve-injured rats Pain 82 1999 65 72
13. B. Malmberg, and T.L. Yaksh Pharmacology of the spinal action of ketorolac morphine ST-91 U50488H and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction Anesthesiology 79 1993 70 281
14. T.J. Maves, P.S. Pechman, S.T. Meller, and G.F. Gebhart Ketorolac potentiates morphine antinociception during visceral nociception in the rat Anesthesiology 80 1994 1094 1101
15. E.A. Romero-Sandoval, J. Mazario, D. Howat, and J.F. Herrero NCX-701 (nitroparacetamol) is an effective antinociceptive agent in rat withdrawal reflexes and wind-up Br J Pharmacol 135 2002 1556 1562
16. E.A. Romero-Sandoval, P. Del Soldato, and J.F. Herrero The effects of sham and full spinalization on the antinociceptive effects of NCX-701 (nitroparacetamol) in monoarthritic rats Neuropharmacology 45 2003 412 419
17. R.E. Solano, and J.F. Herrero Cutaneous responsiveness of rat single motor units activated by natural stimulation J. Neurosci. Methods 73 1997 135 140
18. J. Taylor, B. Mellstrom, I. Fernaud, and J.R. Naranjo Metamizol potentiates morphine effects on visceral pain and evoked c-Fos immunoreactivity in spinal cord Eur J Pharmacol 351 1 1998 39 47
19. S.R. Thornton, A.B. Lohmann, R.A. Nicholson, and F.L. Smith Fentanyl self-administration in juvenile rats that were tolerant and dependent to fentanyl as infants Pharmacol Biochem Behav 65 3 2000 563 570