The antinociceptive effect of the μ-opioid fentanyl is reduced in the presence of the α2-adrenergic antagonist idazoxan in inflammation

Brain Research

Volumn 840, Issue 1-2, 1999, Pages 106-114

  Herrero, Juan F ^a   Solano, Ramon E ^a  

^a UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

Nociception; Noxious stimulation; Pain; Wind up; Withdrawal reflex

Indexed keywords

ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; FENTANYL CITRATE; IDAZOXAN; MU OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HYPERALGESIA; INFLAMMATION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NOCICEPTION; NONHUMAN; PAIN; PAW EDEMA; PRIORITY JOURNAL; RAT; WITHDRAWAL REFLEX;

ADRENERGIC ALPHA-ANTAGONISTS; ANALGESICS, OPIOID; ANIMALS; CARRAGEENAN; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FENTANYL; HINDLIMB; IDAZOXAN; INFLAMMATION; MALE; NOCICEPTORS; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU; REFERENCE VALUES;

EID: 0033523385     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01780-1     Document Type: Article

References (35)

1. 2-adrenoceptor antagonist therapy. Trends Pharmacol. Sci. 13:1992;277-282.
2. Brandt S.A., Livingston A. Receptor changes in the spinal cord of sheep associated with exposure to chronic pain. Pain. 42:1992;323-329.
3. Budai D., Larson A.A. GYKI 52466 inhibits AMPA/Kainate and peripheral mechanical sensory activity. NeuroReport. 5:1994;881-884.
4. Cervero F. Visceral pain: mechanisms of peripheral and central sensitization. Ann. Med. 27:1995;235-239.
5. Clarke R.W., Ford T.W., Taylor J.S. Adrenergic and opioidergic modulation of a spinal reflex in the decerebrated rabbit. J. Physiol. 404:1988;407-417.
6. Cumberbatch M.J., Herrero J.F., Headley P.M. Studies of synaptic transmission in vivo: indirect versus direct effects of (RS)-α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid/kainate antagonists on rat spinal sensory responses. Neurosci. Lett. 204:1996;33-36.
7. 2-Adrenoceptors not imidazole receptors mediate depression of a sacral spinal reflex in the cat. Eur. J. Pharmacol. 195:1991;301-304.
8. Doze V., Chen B.X., Li Z., Maze M. Pharmacological characterization of the receptor mediating the hypnotic action of dexmedetomidine. Acta Vet. Scand. 85:1989;61-64.
9. Drasner K., Fields H.L. Synergy between the antinociceptive effects of intrathecal clonidine and systemic morphine in the rat. Pain. 32:1988;309-312.
10. Dubner R., Ruda M.A. Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15:1992;96-103.
11. Herrero J.F., Headley P.M. Functional evidence for multiple receptor activation by k-ligands in the inhibition of spinal nociceptive reflexes in the rat. Br. J. Pharmacol. 110:1993;303-309.
12. Herrero J.F., Cervero F. Changes in nociceptive reflex facilitation during carrageenan-induced arthritis. Brain Res. 717:1996;62-68.
13. Herrero J.F., Cervero F. Supraspinal influences on the facilitation of rat nociceptive reflexes induced by carrageenan monoarthritis. Neurosci. Lett. 209:1996;21-24.
14. Herrero J.F., Cervero F. Alpha2 adrenergic tonic control in rats with carrageenan-induced hyperalgesia. Soc. Neurosci. Abstr. 22:1996;877.
15. 2 imidazoline ligand, RS 45041, potentiates hyperalgesia in acute arthritis. NeuroReport. 7:1996;1497-1501.
16. 2-adrenoceptors and non-adrenoceptor, imidazoline binding sites in the central nervous system Br. J. Pharmacol. 109:1993;831-837.
17. Hylden J.L.K., Thomas D.A., Iadarola M.J., Nahin R.L., Dubner R. Spinal opioid analgesic effects are enhanced in a model of unilateral inflammation/hyperalgesia: possible involvement of noradrenergic mechanisms. Eur. J. Pharmacol. 194:1991;135-143.
18. Kayser V., Guilbaud G. The analgesic effects of morphine, but not those of the enkephalinase inhibitor thiorphan, are enhanced in arthritic rats. Brain Res. 267:1983;131-138.
19. King A.E., Lopez-Garcia J.A. Excitatory amino acid receptor-mediated neurotransmission from cutaneous afferents in rat dorsal horn in vitro. J. Physiol. 472:1993;443-457.
20. J.D. Levine, Y.O. Taiwo, Inflammatory pain, in: P.D. Wall, R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, pp. 45-56.
21. Mazario J., Roza C., Herrero J.F. The NSAID dexketoprofen trometamol is as potent as μ-opioids in the depression of wind-up and spinal cord nociceptive reflexes in normal rats. Brain Res. 816:1999;512-517.
22. M.A. Nalda, J.L. Gonzalez, Postoperative pain relief with the synergistic interaction of epidural clonidine and morphine, 7th Eur. Congr. Anesthesiol., Stein-Breitner Verlag, Vienna 2, 1986, p. 262.
23. Omote K., Kitahata L.M., Collins J.G., Nakatani K., Nakagawa I. Interaction between opiate subtype and alpha-2 adrenergic agonists in suppression of noxiously evoked activity of WDR neurones in the spinal dorsal horn. Anesthesiology. 74:1991;737-743.
24. Pertovaara A. Antinociception induced by alpha-2-adrenoceptor agonists, with special emphasis on medetomidine studies. Prog. Neurobiol. 40:1993;691-709.
25. 2-adrenoceptors in the central nervous system. Acta Vet. Scand. 85:1989;11-19.
26. Solano R., Herrero J.F. Cutaneous responsiveness of rat single motor units activated by natural stimulation. J. Neurosci. Methods. 73:1997;135-140.
27. Spaulding T.C., Fielding S., Jenafro J.J., Lal H. Antinociceptive activity of clonidine and its potentiation of morphine analgesia. Eur. J. Pharmacol. 58:1979;19-25.
28. Stanfa L.C., Dickenson A.H. Enhanced alpha-2 adrenergic controls and spinal morphine potency in inflammation. NeuroReport. 5:1994;469-472.
29. 2-Adrenoceptor modulation of nociception in rat spinal cord: location, effects and interactions with morphine. Eur. J. Pharmacol. 138:1987;169-177.
30. Sullivan A.F., Kalso E.A., McQuay H.J., Dickenson A.H. The antinociceptive actions of dexmedetomidine on dorsal horn neuronal responses in the anaesthetized rat. Eur. J. Pharmacol. 215:1992;127-133.
31. Tjolsen A., Lund A., Hole K. The role of descending noradrenergic systems in regulation of nociception: the effects of intrathecally administered α-adrenoceptor antagonists and clonidine. Pain. 43:1990;113-120.
32. Thomas D.A., Anton F., Kenshalo D.R. Jr., Williams G., Dubner R Noradrenergic and opioid systems interact to alter the detection of noxious thermal stimuli and facial scratching in monkeys. Pain. 55:1993;63-70.
33. Wilcox G.L., Carlsson K., Jochim A., Jurna I. Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord. Brain Res. 405:1987;84-93.
34. Woolf C.J. Evidence for a central component of post-injury pain hypersensitivity. Nature. 306:1983;686-688.
35. Yaksh T.L. Pharmacology of spinal adrenergic systems which modulate spinal nociceptive processing. Pharmacol. Biochem. Behav. 22:1985;845-858.