Successful treatment of disseminated aspergillosis with the combination of voriconazole, caspofungin, granulocyte transfusions, and surgery followed by allogeneic blood stem cell transplantation in a patient with primary failure of an autologous stem cell graft

European Journal of Haematology

Volumn 74, Issue 5, 2005, Pages 438-441

  Dinser, Robert ^a   Grgic, Aleksandar ^a   Kim, Yoo Jin ^a   Pfreundschuh, Michael ^a   Schubert, Jörg ^a  

^a SAARLAND UNIVERSITY   (Germany)

Author keywords

Aspergillosis; Combination therapy; Multiple myeloma

Indexed keywords

CASPOFUNGIN; PREDNISOLONE; VORICONAZOLE;

ADULT; ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; ARTICLE; ASPERGILLOSIS; CASE REPORT; CHRONIC GRAFT VERSUS HOST DISEASE; CONTROLLED STUDY; DISEASE COURSE; GRAFT FAILURE; GRANULOCYTE TRANSFUSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; MALE; MONOTHERAPY; MULTIPLE MYELOMA; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; RECURRENT DISEASE; RISK FACTOR; TREATMENT OUTCOME;

ANTIFUNGAL AGENTS; ASPERGILLOSIS; DRUG THERAPY, COMBINATION; GRANULOCYTES; HUMANS; LEUKOCYTE TRANSFUSION; MAGNETIC RESONANCE IMAGING; MALE; MELPHALAN; MIDDLE AGED; MULTIPLE MYELOMA; NECROSIS; PEPTIDES, CYCLIC; PYRIMIDINES; STEM CELL TRANSPLANTATION; TRANSPLANTATION, AUTOLOGOUS; TRANSPLANTATION, HOMOLOGOUS; TRIAZOLES;

EID: 17444400983     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2004.00384.x     Document Type: Article

References (15)

1. LIN SJ, SCHRANZ J, TEUTSCH SM. Aspergillus case-fatality rate: systematic review of the literature. Clin Infect Dis 2001;32:358-366.
2. HERBRECHT R, DENNING DW, PATTERSON TF, et al. Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis. N Engl J Med 2002;347:408-415.
3. PACETTI SA, GELONE SP. Caspofungin acetate for treatment of invasive fungal infections. Ann Pharmacother 2003;37:90-98.
4. PEREA S, GONZALEZ G, FOTHERGILL AW, KIRKPATRICK WR, RINALDI MG, PATTERSON TF. In vitro interaction of caspofungin acetate with voriconazole against clinical isolates of Aspergillus spp. Antimicrob Agents Chemother 2002;46:3039-3041.
5. KIRKPATRICK WR, PEREA S, COCO BJ, PATTERSON TF. Efficacy of caspofungin alone and in combination with voriconazole in a guinea pig model of invasive aspergillosis. Antimicrob Agents Chemother 2002;46:2564-2568.
6. MANAVATHU EK, ALANGADEN GJ, CHANDRASEKAR PH. Differential activity of triazoles in two-drug combinations with the echinocandin caspofungin against Aspergillus fumigatus. J Antimicrob Chemother 2003;51:1423-1425.
7. DAMAJ G, IVANOV V, LEBRIGAND B, D'INCAN E, DOGLIO MF, BILGER K, FAUCHER C, VEY N, GASTAUT JA. Rapid improvement of disseminated aspergillosis with caspofungin/voriconazole combination in an adult leukemic patient. Ann Hematol 2004;83:390-393.
8. TRINH JV, STEINBACH WJ, SCHELL WA, KURTZBERG J, GILES SS, PERFECT J. Cerebral phaeohyphomycosis in an immunodeficient child treated medically with combination antifungal therapy. Med Mycol 2003;41:339-345.
9. CASTAGNOLA E, MACHETTI M, CAPPELLI B, MOLINARI AC, MORREALE G, DODERO P, TOMA P, FARACI M. Caspofungin associated with liposomal amphotericin B or voriconazole for treatment of refractory fungal pneumonia in children with acute leukaemia or undergoing allogeneic bone marrow transplant. Clin Microbiol Infect 2004;10:255-257.
10. SIMS-MCCALLUM RP. Triple antifungal therapy for the treatment of invasive aspergillosis in a neutropenic pediatric patient. Am J Health Syst Pharm 2003;60:2352-2356.
11. VERMA A, WILLIAMS S, TRIFILIO S, ZEMBOWER T, MEHTA J. Successful treatment of concomitant pulmonary zygomycosis and aspergillosis with a combination of amphotericin B lipid complex, caspofungin, and voriconazole in a patient on immunosuppression for chronic graft-versus-host disease. Bone Marrow Transplant 2004;epub March 29.
12. GROW WB, MOREB JS, ROQUE D et al. Late onset of invasive Aspergillus infection in bone marrow transplant patients at a university hospital. Bone Marrow Transplant 2002;29:15-19.
13. DE LA ROSA GR, CHAMPLIN RE, KONTOYIANNIS DP. Risk factors for the development of invasive fungal infections in allogeneic blood and marrow transplant recipients. Transplant Infect Dis 20002;4:3-9.
14. BÖHME A, RUHNKE M, BUCHHEIDT D, et al. Treatment of fungal infections in hematology and oncology. Ann Hematol 2003;82(Suppl 2):S133-S140.
15. BELLUCI R, RITZ J. Allogeneic stem cell transplantation for multiple myeloma. Rev Clin Exp Hematol 2002;6:205-224.