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33845555590
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See for example a) M. J. O'Donnell, J. M. Boniece, S. E. Earp, Tetrahedron Lett. 1978, 2641-2644; b) M. J. O'Donnell, R. L. Polt, J. Org. Chem. 1982, 47, 2663-2666; c) M. J. O'Donnell, B. LeClef, D. B. Rusterholtz, L. Ghosez, J.-P. Antoine, M. Navarro, Tetrahedron Lett. 1982, 23, 4259-4262; d) L. Goshez, J.-P. Antoine, E. Deffense, M. Navarro, V. Libert, M. J. O'Donnell, W. A. Bruder, K. Willey, K. Wojciechowski, ibid. 1982, 23, 4255-4258; e) M. J. O'Donnell, K. Wojciechowski, L. Goshez, M. Navarro, F. Sainte, J.-P. Antoine, Synthesis 1984, 313-315; f) M. J. O'Donnell, D. B. Rusterholz, Synth. Commun. 1989, 19, 1157-1165; g) C. Alvarez-Ibarra, A. G. Csákÿ, M. Maroto, M. L. Quiroga, J. Org. Chem. 1995, 60, 6700-6705; h) A. López, M. Moreno-Mañas, R. Pleixats, A. Roglans, J. Ezquerra, C. Pedregal, Tetrahedron 1996, 52, 8365-8386.
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0013487648
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See for example a) M. J. O'Donnell, J. M. Boniece, S. E. Earp, Tetrahedron Lett. 1978, 2641-2644; b) M. J. O'Donnell, R. L. Polt, J. Org. Chem. 1982, 47, 2663-2666; c) M. J. O'Donnell, B. LeClef, D. B. Rusterholtz, L. Ghosez, J.-P. Antoine, M. Navarro, Tetrahedron Lett. 1982, 23, 4259-4262; d) L. Goshez, J.-P. Antoine, E. Deffense, M. Navarro, V. Libert, M. J. O'Donnell, W. A. Bruder, K. Willey, K. Wojciechowski, ibid. 1982, 23, 4255-4258; e) M. J. O'Donnell, K. Wojciechowski, L. Goshez, M. Navarro, F. Sainte, J.-P. Antoine, Synthesis 1984, 313-315; f) M. J. O'Donnell, D. B. Rusterholz, Synth. Commun. 1989, 19, 1157-1165; g) C. Alvarez-Ibarra, A. G. Csákÿ, M. Maroto, M. L. Quiroga, J. Org. Chem. 1995, 60, 6700-6705; h) A. López, M. Moreno-Mañas, R. Pleixats, A. Roglans, J. Ezquerra, C. Pedregal, Tetrahedron 1996, 52, 8365-8386.
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0001147034
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See for example a) M. J. O'Donnell, J. M. Boniece, S. E. Earp, Tetrahedron Lett. 1978, 2641-2644; b) M. J. O'Donnell, R. L. Polt, J. Org. Chem. 1982, 47, 2663-2666; c) M. J. O'Donnell, B. LeClef, D. B. Rusterholtz, L. Ghosez, J.-P. Antoine, M. Navarro, Tetrahedron Lett. 1982, 23, 4259-4262; d) L. Goshez, J.-P. Antoine, E. Deffense, M. Navarro, V. Libert, M. J. O'Donnell, W. A. Bruder, K. Willey, K. Wojciechowski, ibid. 1982, 23, 4255-4258; e) M. J. O'Donnell, K. Wojciechowski, L. Goshez, M. Navarro, F. Sainte, J.-P. Antoine, Synthesis 1984, 313-315; f) M. J. O'Donnell, D. B. Rusterholz, Synth. Commun. 1989, 19, 1157-1165; g) C. Alvarez-Ibarra, A. G. Csákÿ, M. Maroto, M. L. Quiroga, J. Org. Chem. 1995, 60, 6700-6705; h) A. López, M. Moreno-Mañas, R. Pleixats, A. Roglans, J. Ezquerra, C. Pedregal, Tetrahedron 1996, 52, 8365-8386.
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Navarro, M.4
Libert, V.5
O'Donnell, M.J.6
Bruder, W.A.7
Willey, K.8
Wojciechowski, K.9
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17
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0002903295
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See for example a) M. J. O'Donnell, J. M. Boniece, S. E. Earp, Tetrahedron Lett. 1978, 2641-2644; b) M. J. O'Donnell, R. L. Polt, J. Org. Chem. 1982, 47, 2663-2666; c) M. J. O'Donnell, B. LeClef, D. B. Rusterholtz, L. Ghosez, J.-P. Antoine, M. Navarro, Tetrahedron Lett. 1982, 23, 4259-4262; d) L. Goshez, J.-P. Antoine, E. Deffense, M. Navarro, V. Libert, M. J. O'Donnell, W. A. Bruder, K. Willey, K. Wojciechowski, ibid. 1982, 23, 4255-4258; e) M. J. O'Donnell, K. Wojciechowski, L. Goshez, M. Navarro, F. Sainte, J.-P. Antoine, Synthesis 1984, 313-315; f) M. J. O'Donnell, D. B. Rusterholz, Synth. Commun. 1989, 19, 1157-1165; g) C. Alvarez-Ibarra, A. G. Csákÿ, M. Maroto, M. L. Quiroga, J. Org. Chem. 1995, 60, 6700-6705; h) A. López, M. Moreno-Mañas, R. Pleixats, A. Roglans, J. Ezquerra, C. Pedregal, Tetrahedron 1996, 52, 8365-8386.
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O'Donnell, M.J.1
Wojciechowski, K.2
Goshez, L.3
Navarro, M.4
Sainte, F.5
Antoine, J.-P.6
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18
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84973065254
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See for example a) M. J. O'Donnell, J. M. Boniece, S. E. Earp, Tetrahedron Lett. 1978, 2641-2644; b) M. J. O'Donnell, R. L. Polt, J. Org. Chem. 1982, 47, 2663-2666; c) M. J. O'Donnell, B. LeClef, D. B. Rusterholtz, L. Ghosez, J.-P. Antoine, M. Navarro, Tetrahedron Lett. 1982, 23, 4259-4262; d) L. Goshez, J.-P. Antoine, E. Deffense, M. Navarro, V. Libert, M. J. O'Donnell, W. A. Bruder, K. Willey, K. Wojciechowski, ibid. 1982, 23, 4255-4258; e) M. J. O'Donnell, K. Wojciechowski, L. Goshez, M. Navarro, F. Sainte, J.-P. Antoine, Synthesis 1984, 313-315; f) M. J. O'Donnell, D. B. Rusterholz, Synth. Commun. 1989, 19, 1157-1165; g) C. Alvarez-Ibarra, A. G. Csákÿ, M. Maroto, M. L. Quiroga, J. Org. Chem. 1995, 60, 6700-6705; h) A. López, M. Moreno-Mañas, R. Pleixats, A. Roglans, J. Ezquerra, C. Pedregal, Tetrahedron 1996, 52, 8365-8386.
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0028866023
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See for example a) M. J. O'Donnell, J. M. Boniece, S. E. Earp, Tetrahedron Lett. 1978, 2641-2644; b) M. J. O'Donnell, R. L. Polt, J. Org. Chem. 1982, 47, 2663-2666; c) M. J. O'Donnell, B. LeClef, D. B. Rusterholtz, L. Ghosez, J.-P. Antoine, M. Navarro, Tetrahedron Lett. 1982, 23, 4259-4262; d) L. Goshez, J.-P. Antoine, E. Deffense, M. Navarro, V. Libert, M. J. O'Donnell, W. A. Bruder, K. Willey, K. Wojciechowski, ibid. 1982, 23, 4255-4258; e) M. J. O'Donnell, K. Wojciechowski, L. Goshez, M. Navarro, F. Sainte, J.-P. Antoine, Synthesis 1984, 313-315; f) M. J. O'Donnell, D. B. Rusterholz, Synth. Commun. 1989, 19, 1157-1165; g) C. Alvarez-Ibarra, A. G. Csákÿ, M. Maroto, M. L. Quiroga, J. Org. Chem. 1995, 60, 6700-6705; h) A. López, M. Moreno-Mañas, R. Pleixats, A. Roglans, J. Ezquerra, C. Pedregal, Tetrahedron 1996, 52, 8365-8386.
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See for example a) M. J. O'Donnell, J. M. Boniece, S. E. Earp, Tetrahedron Lett. 1978, 2641-2644; b) M. J. O'Donnell, R. L. Polt, J. Org. Chem. 1982, 47, 2663-2666; c) M. J. O'Donnell, B. LeClef, D. B. Rusterholtz, L. Ghosez, J.-P. Antoine, M. Navarro, Tetrahedron Lett. 1982, 23, 4259-4262; d) L. Goshez, J.-P. Antoine, E. Deffense, M. Navarro, V. Libert, M. J. O'Donnell, W. A. Bruder, K. Willey, K. Wojciechowski, ibid. 1982, 23, 4255-4258; e) M. J. O'Donnell, K. Wojciechowski, L. Goshez, M. Navarro, F. Sainte, J.-P. Antoine, Synthesis 1984, 313-315; f) M. J. O'Donnell, D. B. Rusterholz, Synth. Commun. 1989, 19, 1157-1165; g) C. Alvarez-Ibarra, A. G. Csákÿ, M. Maroto, M. L. Quiroga, J. Org. Chem. 1995, 60, 6700-6705; h) A. López, M. Moreno-Mañas, R. Pleixats, A. Roglans, J. Ezquerra, C. Pedregal, Tetrahedron 1996, 52, 8365-8386.
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3843128179
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Heterocycles of this type, derived from 2-hydroxypinan-3-one, have been deprotonated with strong bases (nBuLi, KOtBu): A. El Achgar, M. Boumzebra, M.-L. Roumestant, P. Viallefont, Tetrahedron 1988, 44, 5319-5332.
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37
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0642352331
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PCModel for Windows from Serena Software and Hyperchem from Hypercube were used for these calculations
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PCModel for Windows from Serena Software and Hyperchem from Hypercube were used for these calculations.
-
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38
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0003113195
-
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This hydroxyketone can be prepared from (R)-valine by a six-step procedure or by enzymatic hydrolysis of α-acetoxyisovalerophenone: H. Ohta, M. Ikemoto, H. Ti, Y. Okamoto, G. Tsuchihashi, Chem. Lett. 1986, 1169-1172.
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0642382830
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note
-
Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC-179-168. Copies of the data can be obtained free of charge on application to The Director, CCDC, 12 Union Road, Cambridge CB21EZ, UK (fax: int. code+(1223)336-033; e-mail: deposit@chemcrys.cam.ac.uk).
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C. Cativiela, M. D. Diaz-de-Villegas, J. A. Gálvez, Tetrahedron: Asymmetry, 1994, 5, 261-268.
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Belokon, Y.N.1
Chernoglazova, N.I.2
Kochetkov, C.A.3
Garbalinskaya, N.S.4
Belikov, V.M.5
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