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Volumn 36, Issue 9, 1997, Pages 995-997

Asymmetric Synthesis of α-Methyl α-Amino Acids by Diastereoselective Alkylation of Optically Active 6-Isopropyl-3-methyl-2,3-dihydro-6H-1,4-oxazin-2-ones

Author keywords

Amino acids; Asymmetric alkylations; Ketones; Palladium; Phase transfer catalysis

Indexed keywords


EID: 0030905372     PISSN: 05700833     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.199709951     Document Type: Article
Times cited : (70)

References (43)
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    • PCModel for Windows from Serena Software and Hyperchem from Hypercube were used for these calculations
    • PCModel for Windows from Serena Software and Hyperchem from Hypercube were used for these calculations.
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    • This hydroxyketone can be prepared from (R)-valine by a six-step procedure or by enzymatic hydrolysis of α-acetoxyisovalerophenone: H. Ohta, M. Ikemoto, H. Ti, Y. Okamoto, G. Tsuchihashi, Chem. Lett. 1986, 1169-1172.
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    • note
    • Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Centre as supplementary publication no. CCDC-179-168. Copies of the data can be obtained free of charge on application to The Director, CCDC, 12 Union Road, Cambridge CB21EZ, UK (fax: int. code+(1223)336-033; e-mail: deposit@chemcrys.cam.ac.uk).


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