BMD188, a novel hydroxamic acid compound, demonstrates potent anti- prostate cancer effects in vitro and in vivo by inducing apoptosis: Requirements for mitochondria, reactive oxygen species, and proteases

Pathology and Oncology Research

Volumn 4, Issue 3, 1998, Pages 179-190

  Tang, Dean G ^a,c   Li, Li ^a   Zhu, Zhenyu ^a   Joshi, Bindu ^a   Johnson, Carl R ^a   Marnett, Lawrence J ^d   Honn, Kenneth V ^a,c   Crissman, John D ^b,c   Krajewski, Stanislaw ^e   Reed, John C ^e   Timar, József ^f   Porter, Arthur T ^a,c  

^a WAYNE STATE UNIVERSITY   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c KARMANOS CANCER INSTITUTE   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e Burham Institute   (United States)

^f SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

Apoptosis; Chemotherapy; Free radical; Hydroxamic acid; Mitochondria; Prostate cancer

Indexed keywords

1 HYDROXY 4 (1 NAPHTHYL) 6 OCTYLPIPERIDINE 2 ONE; ANTINEOPLASTIC AGENT; CASPASE INHIBITOR; HYDROXAMIC ACID; REACTIVE OXYGEN METABOLITE; SERINE PROTEINASE INHIBITOR; TOSYLLYSYL CHLOROMETHYL KETONE; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER CHEMOTHERAPY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALE; MITOCHONDRION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PROSTATE CANCER;

EID: 17344366112     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02905247     Document Type: Article

References (2)

1. Tang DG, and Porter AT: Target to apoptosis: A hopeful weapon for prostate cancer. Prostate 32:284-293, 1997.
2. Vukanovic J, and Isaacs JT: Human prostate cancer cells are sensitive to programmed (apoptotic) death induced by the antiangiogenic agent Linomide. Cancer Res 55:3517-3520, 1995.