Cardiovascular and ventilatory response to isocapnic hypoxia at sea level and at 5,050 m

Journal of Applied Physiology

Volumn 80, Issue 5, 1996, Pages 1724-1730

  Insalaco, Giuseppe ^a   Romano, Salvatore ^b   Salvaggio, Adriana ^b   Braghiroli, Alberto ^b   Lanfranchi, Paola ^b   Patruno, Vincenzo ^b   Donner, Claudio F ^b   Bonsignore, Giovanni ^b  

^a CNR   (Italy)

^b NONE

Author keywords

blood pressure; heart rate; high altitude

Indexed keywords

ADULT; ALTITUDE ACCLIMATIZATION; ARTERIAL OXYGEN SATURATION; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR RESPONSE; ELECTROCARDIOGRAM; FEMALE; HEART RATE; HUMAN; HUMAN EXPERIMENT; HYPOXIA; LUNG MINUTE VOLUME; MALE; PRIORITY JOURNAL; REBREATHING; SYMPATHETIC TONE;

EID: 0029863318     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1996.80.5.1724     Document Type: Article

References (32)

1. Aitken, M. L., J. L. Franklin, D. J. Pierson, and R. B. Schoene. Influence of body size and gender on control of ventilation. J. Appl. Physiol. 60: 1894-1899, 1986.
2. Angell, J. E., and M. De Burgh Daly. Cardiovascular responses in apnoeic asphyxia: role of arterial chemoreceptors and the modification of their effects by a pulmonary vagal inflation reflex. J. Physiol. Lond. 201: 87-104, 1969.
3. Bayliss, D. A., and D. E. Millhorn. Central neural mechanism of progesterone action: application to the respiratory system. J. Appl. Physiol. 73: 393-404, 1992.
4. Coleridge, J. C. G., and H. M. Coleridge. Chemoreflex regulation of the heart. In: Handbook of Physiology. The Cardiovascular System. The Heart. Bethesda, MD: Am. Physiol. Soc., 1979, sect. 2, vol. I, chapt. 18, p. 653-676.
5. Coleridge, H. M., J. C. G. Coleridge, and D. Jordan. Integration of ventilatory and cardiovascular control systems. In: The Lung, edited by R. G. Crystal and J. B. West. New York: Raven, 1991, chapt. 5.4.10, p. 1405-1418.
6. Forster, H. V., J. A. Dempsey, E. Virduk, and G. Do Pico. Evidence of altered regulation of ventilation during exposure to hypoxia. Respir. Physiol. 20: 379-392, 1974.
7. Hannhart, B., C. K. Pickett, and L. Grindlay Moore. Effect of estrogen and progesterone on carotid body neural output responsiveness to hypoxia. J. Appl. Physiol. 68: 1909-1916, 1990.
8. Heistad, D. D., and F. M. Abboud. Circulatory adjustments to hypoxia. Circulation 61: 463-470, 1980.
9. Koller, E. A., S. Drechsel, T. Hess, P. Macherel, and U. Boutetlier. Effects of atropine and propanolol on the respiratory, circulatory, and ECG responses to high altitude in man. Eur. J. Appl. Physiol. Occup. Physiol. 57: 163-172, 1988.
10. Koller, E. A., M. Bischoff, A. Buhrer, L. Felder, and M. Schopen. Respiratory, circulatory and neuropsychological responses to acute hypoxia in acclimatized and nonacclimatized subjects. Eur. J. Appl. Physiol. Occup. Physiol. 62: 67-72, 1991.
11. Lahiri, S. Dynamic aspects of regulation of ventilation in man during acclimatization to high altitude. Respir. Physiol. 16: 245-258, 1972.
12. Lahiri, S. Physiologic responses: peripheral chemoreflexes. In: The Lung, edited by R. G. Crystal and J. B. West. New York: Raven, 1991, chapt. 5.4.3, p. 1333-1340.
13. Lugliani, F., B. J. Whipp, and K. Wasserman. A role for the carotid body in cardiovascular control in man. Chest 63: 744-750, 1973.
14. Marshall, J. M. Peripheral chemoreceptors and cardiovascular regulation. Physiol. Rev. 74: 543-594, 1994.
15. Masuyama, S., T. Shinozaki, S. Kohchiyama, S. Okita, H. Kimura, Y. Honda, and T. Kuriyama. Heart rate depression during sleep apnea depends on hypoxic chemosensitivity. Am. Rev. Respir. Dis. 141: 39-42, 1990.
16. 2 inhalation in Caucasians. Respir. Physiol. 16: 337-350, 1972.
17. Rebuck, A. S., M. Kangalee, L. D. Pengelly, and E. J. M. Campbell. Correlation of ventilatory responses to hypoxia and hypercapnia. J. Appl. Physiol. 35: 173-177, 1973.
18. Rebuck, A. S., and E. J. M. Campbell. A clinical method for assessing the ventilatory response to hypoxia. Am. Rev. Respir. Dis. 109: 345-359, 1974.
19. Reeves, J. T., B. M. Groves, J. R. Sutton, P. D. Wagner, A. Cymerman, M. K. Malconian, P. B. Rock, P. M. Young, and C. S. Houston. Operation Everest II: preservation of cardiac function at extreme altitude. J. Appl. Physiol. 63: 531-539, 1987.
20. Sato, M., J. W. Severinghaus, F. L. Powell, F. Xu, and M. J. Spellman, Jr. Augmented hypoxic ventilatory response in men at altitude. J. Appl. Physiol. 73: 101-107, 1992.
21. Savonitto, S., G. Cardellino, G. Doveri, S. Pernpruner, R. Bronzini, N. Milloz, D. Colombo, M. Sardina, G. Nassi, and P. Marraccini. Effect of acute exposure to altitude (3,640 m) on blood pressure response to dynamic and isometric exercise in men with systemic hypertension. Am. J. Cardiol. 70: 1493-1497, 1992.
22. Serebrovskaya, T. V. Comparison of respiratory and circulatory responses to progressive hypoxia and hypercapnia. Respiration 59: 35-41, 1992.
23. Sharma, S. C., V. Balasubramani, O. P. Mathew, and R. S. Hoon. Serial studies of heart rate, blood pressure, and urinary catecholamine excretion on acute induction to high altitude (3,658 m). Indian J. Dis. Chest 19: 16-20, 1977.
24. Somers, V. K., A. L. Mark, D. C. Zavala, and F. M. Abboud. Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J. Appl. Physiol. 67: 2095-2100, 1989.
25. Tatsumi, K., B. Hannhart, and L. G. Moore. Influences of sex steroids on ventilation and ventilatory control. In: Regulation of Breathing, edited by A. Dempsey and A. I. Pack. New York: Dekker, 1995, vol. 79, p. 829-864.
26. Weil, J. V., E. Byrne-Quinn, I. E. Sodal, G. F. Filley, and R. F. Grover. Acquired attenuation of chemoreceptor function in chronically hypoxic man at high altitude. J. Clin. Invest. 50: 186-195, 1971.
27. Weil, J. V. Ventilatory control at high altitude. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 2, chapt. 21, p. 703-728.
28. White, D. P., N. J. Douglas, C. K. Pickett, J. V. Weil, and C. W. Zwillich. Sexual influence on the control of breathing. J. Appl. Physiol. 54: 874-879, 1983.
29. White, D. P., K. Gleeson, C. K. Pickett, A. M. Rannels, A. Cymerman, and J. V. Weil. Altitude acclimatization: influence on periodic breathing and chemoresponsiveness during sleep. J. Appl. Physiol. 63: 401-412, 1987.
30. Wolfel, E. E., M. A. Selland, R. S. Mazzeo, and J. T. Reeves. Systemic hypertension at 4,300 m is related to sympathoadrenal activity. J. Appl. Physiol. 76: 1643-1650, 1994.
31. Zar, J. H. Comparing Simple Linear Regression Equations. Biostatistical Analysis. Englewood Cliffs, NJ: Prentice-Hall, 1974, p. 228-235.
32. Zhuang, J., T. Droma, J. R. Sutton, R. E. Mc Cullough, R. G. Mc Cullough, B. M. Groves, G. Rapmund, C. Janes, S. Sun, and L. G. Moore. Autonomic regulation of heart rate response to exercise in Tibetan and Han residents of Lhasa (3,658 m). J. Appl. Physiol. 75: 1968-1973, 1993.