The combination of epidermal growth factor and transforming growth factor-β induces novel phenotypic changes in mouse liver stem cell lines

Journal of Cell Science

Volumn 110, Issue 24, 1997, Pages 3117-3129

  Isfort, Robert J ^a   Cody, David B ^a   Stuard, Sharon B ^b   Randall, Catherine J ^b   Miller, Catherine ^b   Ridder, Gregg M ^b   Doersen, Claus Jens ^a   Richards, William G ^c   Yoder, Bradley K ^c   Erby Wilkinson, J ^d   Woychik, Richard P ^c  

^a PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^b PROCTER AND GAMBLE COMPANY   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF TENNESSEE   (United States)

Author keywords

Cell scatter; EGF; Liver stem cell line; TGF

Indexed keywords

AMPHIREGULIN; BETACELLULIN; EPIDERMAL GROWTH FACTOR; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL LINE; LIVER REGENERATION; MITOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; STEM CELL;

ANIMALS; CELL LINE; EPIDERMAL GROWTH FACTOR; KINETICS; LIVER; MICE; MITOGENS; PHENOTYPE; SIGNAL TRANSDUCTION; STEM CELLS; TRANSFORMING GROWTH FACTOR BETA;

EID: 17344362019     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Aaronson, S. A. (1991). Growth factors and cancer. Science 254, 1146-1153.
2. Anderson, R. J., Sponsel, H. T., Breckon, R., Marcell, T. and Hoeffler, J. P. (1993). Transforming growth factor-1 regulation of signal transduction in two renal epithelial cell lines. Am. J. Physiol. 265, F584-F591.
3. Arber, N., Zajicek, G. and Ariel, I. (1988). The streaming liver II. Hepatocyte life history. Liver 8, 80-87.
4. Armendariz-Borunda, J., Katai, H., Jones, C. M., Seyer, J. M., Kang, A. H. and Raghow, R. (1993). The transforming growth factor beta gene expression is transiently enhanced at a critical stage during liver regeneration after CC14 treatment. Lab. Invest. 69, 283-294.
5. Aterman, K. (1992). The stem cells of liver ¥a selective review. J. Cancer Res. Clin. Oncol. 118, 87-115.
6. Beerli, R. R. and Hynes, N. E. (1996). Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities. J. Biol. Chem. 271, 6071-6076.
7. Braun, L., Mead, J. E., Panzica, M., Mikumo, R., Bell, G. I. and Fausto, N. (1988). Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation. Proc. Nat. Acad. Sci. USA 85, 1539-1543.
8. Brill, S., Holst, P., Sigal, S., Zvibel, I., Fiorino, A., Ochs, A., Somasundaran, U. and Reid, L. M. (1993). Hepatic progenitor populations in embryonic, neonatal, and adult liver. Proc. Soc. Exp. Biol. Med. 204, 261-269.
9. Cross, M. and Dexter, T. M. (1991). Growth factors in development, transformation, and tumorigenesis. Cell 64, 271-280.
10. Dublin, E. A., Barnes, D. M., Wang, D. Y., King, R. J. B. and Levison, D. A. (1993). TGF alpha and TGF beta expression in mammary carcinoma. J. Pathol. 170, 15-22.
11. Evarts, R. P., Nakatsukasa H., Marsden, E. R., Hu, Z. and Thorgeirsson, S. S. (1992). Expression of transfoming growth factor-alpha in regenerating liver and during hepatic differentiation, Mol. Carcinogen. 5, 25-31.
12. Evarts, R. P., Hu, Z., Fujio, K., Marsden, E. R. and Thorgeirsson, S. S. (1993). Activation of hepatic stem cell compartment in the rat: role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation. Cell Growth Differ. 4, 555-561.
13. Fabregat, I., Sanchez, A., Alvarez, A. M., Nakamura, T. and Benito, M. (1996). Epidermal growth factor, but not hepatocyte growth factor, suppresses the apoptosis induced by transforming growth factor-beta in fetal hepatocytes in primary culture. FEBS Lett. 384, 14-18.
14. Factor, V. M., Radaeva, S. A. and Thorgeirsson, S. S. (1994). Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse. Am. J. Pathol. 145, 409-422.
15. Fausto, N., Laird, A. D. and Webber, E. M. (1995). Role of growth factors and cytokines in hepatic regeneration. FASEB J. 9, 1527-1536.
16. Heldin, C. H. and Westermark, B. (1984). Growth factors: mechanisms of action and relation to oncogenes. Cell 37, 9-20.
17. Isfort, R. J., Cody, D. B., Doersen, C. J., Kerckaert, G. A. and LeBoeuf, R. A. (1994). Alterations in cellular differentiation, mitogenesis, cytoskeleton and growth characteristics during Syrian hamster embryo cell multistep in vitro transformation. Int. J. Cancer 59, 114-125.
18. Isfort, R. J., Stuard, S. B., Cody, D. B., Ridder, G. M. and LeBoeuf, R. A. (1995). Modulation of the platelet-derived-growth-factor-induced calcium signal by extracellular/intracellular pH in Syrian hamster embryo cells. Eur. J. Biochem. 234, 801-810.
19. Isfort, R. J., Cody, D. B., Richards, W. G., Yoder, B. K., Wilkinson, J. E. and Woychik, R. P. (1997a). Characterization of growth factor responsiveness and alterations in growth factor homeostasis involved in the tumorigenic conversion of mouse oval cells. Growth Factors (in press).
20. Isfort, R. J., Cody, D. B., Doersen, C. J., Richards, W. G., Yoder, B. K., Wilkinson, J. E., Kier, L. D., Jirtle, R. L. and Woychik, R. P. (1997b). Characterization of the tetratricopeptide repeat containing Tg737 gene as a tumor suppressor gene altered in multiple types of neoplasia. Oncogene (in press).
21. Isfort, R. J., Cody, D. B., Stuard, S. B., Ridder, G. M. and LeBoeuf, R. A. (1996c). Calcium functions as a transcriptional and mitogenic repressor in Syrian hamster embryo cells: roles of intracellular pH and calcium in controlling embryonic cell differentiation and proliferation. Exp. Cell Res. 226, 363-371.
22. Kerckaert, G. A., LeBoeuf, R. A. and Isfort, R. J. (1996). pH effects on the lifespan and transformation frequency of Syrian hamster embryo (SHE) cells. Carcinogenesis 17, 1819-1824,
23. Marceau, N., Blouin, M. J., Germain, L. and Noel, M. (1989). Role of different epithelial cell types in liver ontogenesis, regeneration and neoplasia. In Vitro Cell. Dev. Biol. 25, 336-341.
24. Marceau, N. (1990). Biology of disease: cell lineages and differentiation programs in epidermal, urothelial and hepatic tissues and their neoplasms. Lab. Invest. 63, 4-20.