G-protein Golfalpha (GNAL) is expressed in the vestibular end organs and primary afferent neurons of Rattus norvegicus

Journal of Vestibular Research: Equilibrium and Orientation

Volumn 15, Issue 1, 2005, Pages 11-15

  Wackym, P Ashley ^a   Cioffi, Joseph A ^a   Erbe, Christy B ^a   Popper, Paul ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Efferent vestibular system; G protein; Golfalpha; Olfactory; Receptor; Vestibular

Indexed keywords

COMPLEMENTARY DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN GOLFALPHA; MEMBRANE RECEPTOR; UNCLASSIFIED DRUG;

ANATOMY; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CORPUS STRIATUM; DNA LIBRARY; FEMALE; GANGLION; GENE EXPRESSION; IN SITU HYBRIDIZATION; MALE; MUSCLE SPINDLE AFFERENT NERVE; NERVE CELL; NEUROEPITHELIUM; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VESTIBULAR SYSTEM;

ANIMALS; DEOXYRIBONUCLEASE BAMHI; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS; IN SITU HYBRIDIZATION; MALE; NEURONS, AFFERENT; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RIBONUCLEASES; VESTIBULAR NERVE; VESTIBULE;

EID: 17244366311     PISSN: 09574271     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. C.D. Balaban, Neural substrates linking balance control and anxiety, Physiol Behav 77(4-5) (2002), 469-475.
2. C.D. Balaban and J.F. Thayer, Neurological bases for balance-anxiety links, J Anxiety Disord 15(1-2) (2001), 53-79.
3. W.H. Berrettini, J. Vuoristo, T.N. Ferraro, B.J. Buono, D. Wildenauer and L. Ala-Kokko, Human G(olf) gene polymorphisms and vulnerability to bipolar disorder, Psychiatr Genet 8(4) (1998), 235-238.
4. J.A. Cioffi, C.B. Erbe, R. Raphael, A.E. Kwitek, U.K. Tiwari, H.J. Jacob, P. Popper and P.A. Wackym, Expression of G-protein alpha subunits in the rat vestibular periphery and their chromosomal mapping, Acta Otolaryngol (Stockh) 123(9) (2003), 1027-1034.
5. J.A. Cioffi, P.A. Wackym, C.B. Erbe, W. Gaggl and P. Poppe, Characterization of G-protein Gαi2 splice variants expressed in the vestibular periphery of Rattus norvegicus, Mol Brain Res (2005), in press.
6. J. De Rooij, H. Rehmann, M. van Triest, R.H. Cool, A. Wittinghofer and J.L. Bos, Mechanisms of regulation of the Epac family of cAMP-dependent RapGEFs, J Biol Chem 275 (2000), 20829-20836.
7. M.J. Drescher, R.L. Barretto, D. Chaturvedi, K.W. Beisel, J.S. Hatfield, K.M. Khan and D.J. Drescher, Expression of subunits for the cAMP-sensitive, olfactory cyclic nucleotide-gated ion channel in the cochlea: implications for signal transduction, Mol Brain Res 98 (2002), 1-14.
8. S. Firestein, How the olfactory system makes sense of scents, Nature 413 (2001), 211-218.
9. B. Fish and W.J. Dixon, Vestibular hyporeactivity in infants at risk for schizophrenia. Association with critical developmental disorders, Arch Gen Psychiatry 35(8) (1978), 963-971.
10. A.G. Gordon, Peripheral vestibular pathology in schizophrenic infants, Arch Gen Psychiatry 36(13) (1979), 1462-1464.
11. A. Guenifi, G.M. Portela-Gomes, L. Grimelius, S. Efendic and S.M. Abdel-Halim, Adenylyl cyclase isoform expression in non-diabetic and diabetic Goto-Kakizaki (GK) rat pancreas. Evidence for distinct overexpression of type-8 adenylyl cyclase in diabetic GK rat islets, Histochem Cell Biol 113 (2000), 81-89.
12. T. Iiri, S.M. Bell, T.J. Baranski, T. Fujita and H.R. Bourne, A Gsa mutant designed to inhibit receptor signaling through Gs, Proc Natl Acad Sci USA 96 (1999), 499-504.
13. C.A. Leech, G.G. Holz, O. Chepurny and J.F. Habener, Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic β-cells, Biochem Biophys Res Commun 278 (2000), 44-47.
14. K.L. Régnauld, E. Leteurtre, S.J. Gutkind, C.P. Gespach and S. Emani, Activation of adenylyl cyclases, regulation of insulin status, and cell survival by Gaolf in pancreatic β-cells, Am J Physiol Regulatory Integrative Comp Physiol 282 (2002), R870-R880.
15. G.V. Ronnett and C. Moon, G proteins and olfactory signal transduction, Annu Rev Physiol 64 (2002), 189-222.
16. J.T. Vuoristo, W.H. Berrettini, J. Overhauser, D.J. Prockop, T.N. Ferraro and L. Ala-Kokko, Sequence and genomic organization of the human G-protein Golfalpha gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia, Mol Psychiatry 5(5) (2000), 495-501.
17. P.A. Wackym, M. Troyanovskaya and P. Popper, Differential amplification of adenylyl cyclase isoform cDNAs in the rat vestibular periphery, Brain Res 859/2 (2000), 378-380.
18. T. Waldeck, B. Wyszynski and A. Medalia, The relationship between Usher's syndrome and psychosis with Capgras syndrome, Psychiatry 64(3) (2001), 248-255.
19. M.D. Weston, M.W. Luijendijk, K.D. Humphrey, C. Moller and W.J. Kimberling, Mutations in the VLGR1 gene implicate G-protein signaling in the pathogenesis of Usher syndrome type II, Am J Hum Genet 74(2) (2004), 357-366.