Endoglin gene polymorphism as a risk factor for sporadic intracerebral hemorrhage

Annals of Neurology

Volumn 41, Issue 5, 1997, Pages 683-686

  Alberts, M J ^a   Davis, J P ^a   Graffagnino, C ^a   McClenny, C ^a   Delong, D ^a   Granger, C ^a   Herbstreith, M H ^a   Boteva, K ^a   Marchuk, D A ^a   Roses, A D ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENDOGLIN; RNA;

ADULT; AGED; ARTICLE; BRAIN HEMORRHAGE; CEREBROVASCULAR DISEASE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; STROKE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; CEREBRAL HEMORRHAGE; CONFIDENCE INTERVALS; DNA; FEMALE; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PROSPECTIVE STUDIES; RECEPTORS, CELL SURFACE; RISK FACTORS; RNA; VASCULAR CELL ADHESION MOLECULE-1;

EID: 17144461860     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410410519     Document Type: Article

References (15)

1. Broderick JP, Brott T, Tomsick T, et al. Intracerebral hemorrhage more than twice as common as subarachnoid hemorrhage. J Neurosurg 1993;78:188-191
2. Wityk RJ, Caplan LR. Hypertensive intracerebral hemorrhage. Epidemiology and clinical pathology. Neurosurg Clin North Am 1992;3:521-532
3. Broderick J, Brott T, Tomsick T, et al. Lobar hemorrhage in the elderly. The undiminishing importance of hypertension. Stroke 1993;24:49-51
4. Levy E, Carman MD, Fernandez MI, et al. Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. Science 1990;248:1124-1126
5. Levy E, Lopez OC, Ghiso J, et al. Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases. J Exp Med 1989;169:1771-1778
6. Graffagnino C, Herbstreith MH, Roses AD, et al. A molecular genetic study of intracerebral hemorrhage. Arch Neurol 1994; 51:981-984
7. Graffagnino C, Herbstreith M, Schmechel D, et al. Cystatin C mutation in an elderly man with sporadic amyloid angiopathy and intracerebral hemorrhage. Stroke 1995;26:2190-2193
8. Gougos A, Letarte M. Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells. J Biol Chem 1990;265:8361-8364
9. McAllister KA, Grogg KM, Johnson DW, et al. Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nature Genet 1994;8:345-351
10. Dausset J. Le centre d'etude du polymorphisme humain. Le Presse Med 1986;15:1801-1802
11. Saunders A, Schmader K, Breitner J, et al. Apolipoprotein E ε4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases. Lancet 1993;342:710-711
12. McAllister K, Baldwin M, Thukkani A, et al. Six novel mutations in the endoglin gene in hereditary hemorrhagic telangiectasia type 1 suggest a dominant-negative effect of receptor function. Hum Mol Genet 1995;4:1983-1985
13. Orita M, Iwahana H, Kanazawa H, et al. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci USA 1989;86:2766-2770
14. Wragg M, Hutton M, Talbot C. Genetic association between intronic polymorphism in presenelin-1 gene and late-onset Alzheimer's disease. Lancet 1996;347:509-512
15. Kase C, Mohr J, Caplan L. Intracerebral hemorrhage. In: Barnett HJM, Mohr JP, Stein BM, Yatsu FM, eds. Stroke. Pathophysiology, diagnosis, and management. New York: Churchill Livingstone, 1992:561-616