Contribution of abnormal insulin secretion and insulin resistance to the pathogenesis of type 2 diabetes in myotonic dystrophy

Diabetes Care

Volumn 26, Issue 7, 2003, Pages 2112-2118

  Perseghin, Gianluca ^a,d   Caumo, Andrea ^a   Arcelloni, Cinzia ^a   Benedini, Stefano ^a   Lanzi, Roberto ^a   Pagliato, Emanuela ^b   Sereni, Lucia Piceni ^a   Testolin, Giulio ^b   Battezzati, Alberto ^a,b   Comi, Giancarlo ^c   Comola, Mauro ^c   Luzi, Livio ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^d Unit of Clinical Spectroscopy   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; PROINSULIN;

ARTICLE; CLINICAL ARTICLE; COMORBIDITY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; HETEROZYGOSITY; HUMAN; INSULIN RELEASE; INSULIN RESISTANCE; MUTATION; MYOTONIC DYSTROPHY; NON INSULIN DEPENDENT DIABETES MELLITUS; ORAL GLUCOSE TOLERANCE TEST; RISK ASSESSMENT; RNA METABOLISM; ADULT; BLOOD; CALORIC INTAKE; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HYPERINSULINISM; KINETICS; MALE; METABOLISM; NUCLEAR FAMILY; PATHOPHYSIOLOGY; SECRETION;

ADULT; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; ENERGY INTAKE; FEMALE; GLUCOSE CLAMP TECHNIQUE; GLUCOSE TOLERANCE TEST; HUMANS; HYPERINSULINISM; INSULIN; INSULIN RESISTANCE; KINETICS; MALE; MYOTONIC DYSTROPHY; NUCLEAR FAMILY;

EID: 17144460631     PISSN: 01495992     EISSN: None     Source Type: Journal    
DOI: 10.2337/diacare.26.7.2112     Document Type: Article

References (29)

1. Harper PS: Myotology. Engel AG, Banker BQ, Eds. New York, McGraw-Hill, 1986, p. 1267-1311
2. Harley HG, Brook JO, Rundle SA, Crow S, Reardon W, Buckler AJ, Harper PS, Housman DE, Shaw DJ: Expansion of an unstable DNA region and phenotypic variation in myotonic dystrophy. Nature 355:545-546, 1992
3. Gorden P, Griggs RC, Nissley SP, Roth J, Engel WK: Studies of plasma insulin in myotonic dystrophy. J Clin Endocrinol Metab 29:684-690, 1969
4. Huff TA, Horon S, Lebovitz HE: Abnormal insulin secretion in myotonic dystrophy. N Engl J Med 277:837-841, 1967
5. Walsh JC, Turtle JR, Miller JR, McLeod JG: Abnormalities of insulin secretion in dystrophia myotonica. Brain 93:731-742, 1970
6. Tevaarwerk GJM, Strickland KP, Lin CH, Hudson AJ: Studies of insulin resistance and insulin receptor binding in myotonia dystrophica. J Clin Endocrinol Metab 49: 216-222, 1979
7. Moxley III RT, Griggs RC, Goldblat D: Muscle insulin resistance in myotonic dystrophy: effect of supraphysiologic insulinization. Neurology 30:1077-1083, 1980
8. Morrone A, Pegoraro E, Angelini C, Zammarchi E, Marconi G, Hoffman EP: RNA metabolism in myotonic dystrophy: patient muscle shows decreased insulin receptor RNA and protein consistent with abnormal insulin resistance. J Clin Invest 99:1691-1698, 1997
9. Savkur RS, Philips AV, Cooper TA: Aberrant regulation of insulin receptor alternative splicing is associated with insulin resistance in myotonic dystrophy. Not Genet 29:40-47, 2001
10. Wang J, Pegoraro E, Menegazzo E, Gennarelli M, Hoop RC, Angelini C, Hoffman EP: Myotonic dystrophy: evidence for a dominant-negative RNA mutation. Hum Mol Genet 4:599-606, 1995
11. Perseghin G, Ghosh S, Gerow K, Shulman GI: Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study. Diabetes 46:1001-1009, 1997
12. National Diabetes Data Group: Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance. Diabetes 28:1039-1057, 1979
13. Perseghin G, Regalia E, Battezzati A, Vergani S, Pulvirenti A, Terruzzi I, Baratti D, Bozzetti F, Mazzaferro V, Luzi L: Regulation of glucose homeostasis in humans with denervated livers. J Clin Invest 100: 931-941, 1997
14. 13C NMR spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600-1606, 1999
15. Monti LD, Sandoli EP, Phan VC, Piatti PM, Costa S, Secchi A, Pozza G: A sensitive and reliable method for assaying true human insulin without interaction with human proinsulin-like molecules. Acta Diabetol 32:57-63, 1995
16. Perseghin G, Mazzaferro V, Piceni Sereni L, Regalia E, Benedini S, Bazzigaluppi E, Pulvirenti A, Antonio Silva Leão A, Calori G, Romito R, Baratti D, Luzi L: Contribution of reduced insulin sensitivity and secretion to the pathogenesis of hepatogenous diabetes: effect of liver transplantation. Hepatology 31:694-703, 2000
17. Battezzati A, Simonson DC, Luzi L, Matthews DE: Glucagon increases glutamine uptake without affecting glutamine release in humans. Metabolism 47:713-723, 1998
18. Steele R: Influence of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acaci Sci 82:420-431, 1959
19. Hawk PD: Kjeldhal method. In Practical Physiological Chemistry. 12th ed. Blakiston, Toronto, 1947, p. 814-822
20. Perseghin G, Caumo A, Caloni M, Testolin G, Luzi L: Incorporation of the fasting plasma FFA concentration into QUICKI improves its association with insulin sensitivity in nonobese individuals. J Clin Endocrinol Metab 86:4776-4781, 2001
21. Jensen CC, Cnop M, Hull RL, Fujimoto WY, Kahn SE, and the American Diabetes Association GENNID Study Group: β-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the U.S. Diabetes 51:2170-2178, 2002
22. Krentz AJ, Clark PM, Cox L, Williams AC, Nattrass M: Hyperproinsulinemia in patients with myotonic dystrophy. Diabetologia 35:1170-1172, 1992
23. Luzi L, Battezzati A, Perseghin G, Bianchi E, Secchi A, La Rocca E, Ferrari G, Staudacher D, Di Carlo V, Pozza G: Feedback inhibition of insulin secretion is mediated by neural control in humans. Diabetes 41: 1632-1639, 1992
24. Kahn SE, Halban PA: Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM. Diabetes 46:1725-1732, 1997
25. Zethelius B, Byberg L, Hales CN, Lithell H, Berne C: Proinsulin and acute insulin response independently predict type 2 diabetes mellitus in men: report from 27 years of follow-up study. Diabetologia 46: 20-26, 2003
26. ++ homeostasis in skeletal muscle cells. J Clin Invest 100:1440-1447, 1997
27. ++ signals in pancreatic islet cells. Diabetes 48:1971-1978, 1999
28. Annane D, Duboc D, Mazoyer B, Merlet P, Fiorelli M, Eymard B, Radvanyi H, Junien C, Fardeau M, Gajdos P, Guerin F, Syrota A: Correlation between decreased myocardial glucose phosphorylation and the DNA mutation size in myotonic dystrophy. Circulation 90:2629-2634, 1994
29. Novelli G, Gennarelli M, Menegazzo E, Angelini C, Dallapiccola B: Discordant clinical outcome in myotonic dystrophy relatives showing (CTG)n > 700 repeats. Neuromusc Disord 5:157-159, 1995