Effect of a novel bifunctional endothelin receptor antagonist, IRL 3630A, on guinea pig respiratory mechanics

European Journal of Pharmacology

Volumn 406, Issue 1, 2000, Pages 139-147

  Makatani, Maki ^a   Fujitani, Yasushi ^b   Takimoto, Misato ^c   Oda, Kyoko ^a   Sasaki, Yukio ^d   Hori, Seiji ^b   Inui, Takashi ^b   Sakaki, Junichi ^a   Okada, Toshikazu ^a   Hoshiko, Kenichiro ^a   Yamamura, Takaki ^a,e  

^a Takarazuka Research Institute   (Japan)

^b OSAKA BIOSCIENCE INSTITUTE   (Japan)

^c PROCTER AND GAMBLE COMPANY   (United States)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

^e NOVARTIS PHARMA K K   (Japan)

Author keywords

Endothelin; Endothelin ETA ETB receptor antagonist bifunctional; IRL 3630A; Respiratory mechanics

Indexed keywords

4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; IRL 3630A; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BREATHING MECHANICS; CONTROLLED STUDY; GUINEA PIG; ISOLATED ORGAN; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; TRACHEA;

AIRWAY RESISTANCE; ANIMALS; BINDING, COMPETITIVE; BIPHENYL COMPOUNDS; CALCIUM; CELL LINE; CHO CELLS; CRICETINAE; DIOXOLES; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIN-1; GUINEA PIGS; HUMANS; LUNG COMPLIANCE; MALE; MUSCLE CONTRACTION; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; RESPIRATORY MECHANICS; TRACHEA;

EID: 17144435636     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00652-X     Document Type: Article

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