Induction of Micronuclei in Proestrus Vaginal Cells from Colchicine- and Cyclophosphamide-Treated Rats

Environmental and Molecular Mutagenesis

Volumn 42, Issue 4, 2003, Pages 306-310

  Zúñiga González, Guillermo ^a   Gomez Meda B C ^a,b   Zamora Perez, A ^a,b   Ramos Ibarra, M L ^a,b   Batista Gonzalez C M ^a,b   Espinoza Jimenez S ^b   Gallegos Arreola, M P ^a   Alvarez Moya, C ^b   Torres Bugarin O ^c  

^a INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^b UNIVERSITY OF GUADALAJARA   (Mexico)

^c UNIVERSIDAD AUTÓNOMA DE GUADALAJARA   (Mexico)

Author keywords

Colchcine; Cyclophosphamide; Micronuclei; Proestrus; Rat; Vaginal cells

Indexed keywords

COLCHICINE; CYCLOPHOSPHAMIDE;

ANIMAL CELL; ARTICLE; CELL COUNT; CELL CYCLE; CELL PROLIFERATION; CHROMOSOME DAMAGE; CONTROLLED STUDY; FEMALE; MICRONUCLEUS; NONHUMAN; PROESTRUS; RAT; VAGINA;

ANIMALS; COLCHICINE; CYCLOPHOSPHAMIDE; CYTOPLASM; FEMALE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; MUTAGENICITY TESTS; MUTAGENS; PROESTRUS; RATS; RATS, WISTAR; TIME FACTORS; VAGINA;

ANIMALIA;

EID: 17144433990     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/em.10202     Document Type: Article

References (24)

1. Frye CA, Erskine MS. 1990. Influence of time of mating and paced copulation on induction of pseudopregnancy in cyclic female rats. J Reprod Fertil 90:375-385.
2. Harper BL, Ramanujam VM, Legator MS. 1989. Micronucleus formation by benzene, cyclophosphamide, benzo[a]pyrene, and benzidine in male, female, pregnant female, and fetal mice. Teratog Carcinog Mutagen 9:239-252.
3. Hayashi M, Kodama Y, Awogi T, Suzuki T, Asita AO, Sofuni T. 1992. The micronucleus assay using peripheral blood reticulocytes from mitomycin-C and cyclophosphamide-treated rats. Mutat Res 278:209-213.
4. Hayashi M, MacGregor JT, Gatehouse DG, Adler ID, Blakey DH, Dertinger SD, Krishna G, Morita T, Russo A, Sutou S. 2000. In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring. Environ Mol Mutagen 35:234-252.
5. Heddle JA, Cimino MC, Hayashi M, Romagna F, Shelby MD, Tucker JD, Vanparys P, MacGregor JT. 1991. Micronuclei as an index of cytogenetic damage: past, present, and future. Environ Mol Mutagen 18:277-291.
6. Henderson L, Fedyk J, Windebank S, Smith M. 1993. Induction of micronuclei in rat bone marrow and peripheral blood following acute and subchronic administration of azathioprine. Mutat Res 291:79-85.
7. Jena GB, Bhunya SP. 1995. Use of chick, Gallus domesticus, as an in vivo model for the study of chromosome aberration: A study with mitomycin C and probable location of a "hot spot." Mutat Res 334:167-174.
8. Krishna G, Petrere J, Anderson J, Theiss J. 1995. Use of cyclophosphamide as a positive control in dominant lethal and micronucleus assay. Mutat Res 335:331-337.
9. Poole TB, Robinson R. 1994. The UFAW handbook on the care and management of laboratory animals. London: Longman Scientific Technical. p 3309-330.
10. Ramírez-Muñoz MP, Zúñiga G, Torres-Bugarín O, Portilla E, García-Martínez D, Ramos A, Cantú JM, Sánchez-Corona J. 1999. Evaluation of the micronucleus test in peripheral blood erythrocytes by use of the splenectomized model. Lab Anim Sci 49:418-420.
11. Rodríguez-Ariza A, Nieves A, Navas JI, Dorado G, López-Barea J, Pueyo C. 1992. Metal mutagenicity and biochemical studies on bivalve molluscs from Spanish coasts. Environ Mol Mutagen 19:112-124.
12. Romagna F, Staniforth CD. 1989. The automated bone marrow micronucleus test. Mutat Res 213:91-104.
13. Salas-Valdés A. 1979. A quick and inexpensive staining method for vaginal smears. Arch Invest Med 10:147-150.
14. Shelby MD, Erexson GL, Hook GJ, Tice RR. 1993. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: results with 49 chemicals. Environ Mol Mutagen 21:160-179.
15. Suzuki Y, Shimizu H, Nagae Y, Fukumoto M, Okonogi H, Kadokura M. 1993. Micronucleus test and erythropoiesis: effect of cobalt on the induction of micronuclei by mutagens. Environ Mol Mutagen 22: 101-106.
16. Tice RR, Erexson GL, Hilliard CJ, Huston JL, Boehm RM, Gulati D, Shelby MD. 1990. Effect of treatment protocol and sample time on the frequencies of micronucleated polychromatic erythrocytes in mouse bone marrow and peripheral blood. Mutagenesis 5:313-321.
17. Torres-Bugarín O, De Anda-Casillas A, Ramírez-Muñoz MP, Sánchez-Corona J, Cantú JM, Zúñiga G. 1998. Determination of diesel genotoxicity in firebreathers by micronuclei and nuclear abnormalities in buccal mucosa. Mutat Res 413:277-281.
18. Trzos RJ, Petzold GL, Brunden MN, Swenberg JA. 1978. The evaluation of sixteen carcinogens in the rat using the micronucleus test. Mutat Res 58:79-86.
19. Turner CD. 1966. General endocrinology. Philadelphia: WB Saunders. p 442-446.
20. Von Ledebur M, Schmid W. 1973. The micronucleus test. Methodological aspects. Mutat Res 19:109-117.
21. Yamamoto KI, Kikuchi YA. 1980. Comparison of diameters of micronuclei induced by clastogens and by spindle poisons. Mutat Res 71:127-131.
22. Zúñiga G, Torres-Bugarín O, Ramírez-Muñ oz MP, Delgado-Lamas JL, De Loza-Saldaña R, Cantú JM. 1996. Micronucleated erythrocytes in splenectomized patients with and without chemotherapy. Mutat Res 361:107-112.
23. Zúñiga-González G, Torres-Bugarín O, Ramos-Ibarra ML, Zamora-Perez A, Gómez-Meda BC, Ventura-Aguilar AJ, Ramos-Mora A, Ortiz GG, Alvarez-Moya C, González-Rodríguez A, Luna-Aguirre J, Gallegos-Arreola MP. 2001a. Variation of micronucleated erythrocytes in peripheral blood of Sciurus aureogaster in relation to age: an increment of micronucleated polychromatic erythrocytes after the administration of colchicine. Environ Mol Mutagen 37:173-177.
24. Zúñiga-González G, Torres-Bugarín O, Zamora Pérez A, Gómez-Meda BC, Ramos-Ibarra ML, Martí nez-González S, González-Rodríguez A, Luna-Aguirre J, Ramos-Mora A, Ontiveros-Lira D, Gallegos-Arreola MP. 2001b. Differences in the number of micronucleated erythrocytes among young and adult animals including humans. Spontaneous micronuclei in 43 species. Mutat Res 494:161-1167.