Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation

FEBS Journal

Volumn 272, Issue 7, 2005, Pages 1600-1615

  Ziegler, Slava ^a   Rohrs, Sonja ^a   Tickenbrock, Lara ^b   Möröy, Tarik ^c   Klein Hitpass, Ludger ^c   Vetter, Ingrid R ^a   Müller, Oliver ^a  

^a MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^b UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Microarray analysis; Statistical analysis of transcription factor motifs; Transcription factor binding site; Wnt pathway; Wnt target gene

Indexed keywords

APC PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; GLYCOGEN SYNTHASE KINASE 3BETA; MYC PROTEIN; RNA; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; WNT PROTEIN; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 1;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DOWN REGULATION; EXPRESSED SEQUENCE TAG; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE SEQUENCE; GENE TARGETING; GENOME; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MICROARRAY; PROTEIN MOTIF; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM;

ANIMALS; DATA INTERPRETATION, STATISTICAL; GENE EXPRESSION REGULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MODELS, GENETIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS (GENETICS); WNT PROTEINS; WNT1 PROTEIN;

EID: 17144418146     PISSN: 1742464X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2005.04581.x     Document Type: Article

References (40)

1. Huelsken J & Birchmeier W (2001) New aspects of Wnt signaling pathways in higher vertebrates. Curr Opin Genet Dev 11, 547-553.
2. Nusse R (1999) WNT targets. Repression and activation. Trends Genet 15, 1-3.
3. Giles RH, van Es JH & Clevers H (2003) Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 1653, 1-24.
4. Tetsu O & McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398, 422-426.
5. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, Morin PJ, Vogelstein B & Kinzler KW (1998) Identification of c-MYC as a target of the APC pathway. Science 281, 1509-1512.
6. Howe LR, Crawford HC, Subbaramaiah K, Hassell JA, Dannenberg AJ & Brown AM (2001) PEA3 is up-regulated in response to Wnt1 and activates the expression of cyclooxygenase-2. J Biol Chem 276, 20108-20115.
7. van, WM, Sancho E, Verweij C, de Lau W, Oving I, van der Huristone AHK, Batlle E, Coudreuse D, Haramis AP, Tjon-Pon-Fong M et al. (2002) The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111, 241-250.
8. Wu S, Cetinkaya C, Munoz-Alonso MJLN, Bahram F, Beuger V, Eilers M, Leon J & Larsson LG (2003) Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter. Oncogene 22, 351-360.
9. Tice DA, Soloviev I & Polakis P (2002) Activation of the Wnt pathway interferes with serum response element-driven transcription of immediate early genes. J Biol Chem 277, 6118-6123.
10. Willert J, Epping M, Pollack JR, Brown PO & Nusse R (2002) A transcriptional response to Wnt protein in human embryonic carcinoma cells. BMC Dev Biol 2, 8.
11. Schwartz DR, Wu R, Kardia SL, Levin AM, Huang CC, Shedden KA, Kuick R, Misek DE, Hanash SM, Taylor JM et al. (2003) Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Cancer Res 63, 2913-2922.
12. Staal FJ, Weerkamp F, Baert MR, van den Burg CM, van Noort M, de Haas EF & van Dongen JJ (2004) Wnt target genes identified by DNA microarrays in immature CD34+ thymocytes regulate proliferation and cell adhesion. J Immunol 172, 1099-1108.
13. Nusse R, van Ooyen A, Cox D, Fung YK & Varmus H (1984) Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature 307, 131-136.
14. Jue SF, Bradley RS, Rudnicki JA, Varmus HE & Brown AM (1992) The mouse Wnt-1 gene can act via a paracrine mechanism in transformation of mammary epithelial cells. Mol Cell Biol 12, 321-328.
15. Mason JO, Kitajewski J & Varmus HE (1992) Mutational analysis of mouse Wnt-1 identifies two temperature-sensitive alleles and attributes of Wnt-1 protein essential for transformation of a mammary cell line. Mol Biol Cell 3, 521-533.
16. Prieve MG & Moon RT (2003) Stromelysin-1 and mesothelin are differentially regulated by Wnt-5a and Wnt-1 in C57mg mouse mammary epithelial cells. BMC Dev Biol 3, 2.
17. Shimizu H, Julius MA, Giarre M, Zheng Z, Brown AM & Kitajewski J (1997) Transformation by Wnt family proteins correlates with regulation of beta-catenin. Cell Growth Differ 8, 1349-1358.
18. Pennica D, Swanson TA, Welsh JW, Roy MA, Lawrence DA, Lee J, Brush J, Taneyhill LA, Deuel B, Lew M et al. (1998) WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1 -transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci USA 95, 14717-14722.
19. Tao W, Pennica D, Xu L, Kalejta RF & Levine AJ (2001) Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 15, 1796-1807.
20. Ziemer LT, Pennica D & Levine AJ (2001) Identification of a mouse homolog of the human BTEB2 transcription factor as a beta-catenin-independent Wnt-1-responsive gene. Mol Cell Biol 21, 562-574.
21. Vaidya AB, Lasfargues EY, Sheffield JB & Coutinho WG (1978) Murine mammary tumor virus (MuMTV) infection of an epithelial cell line established from C57BL/6 mouse mammary glands. Virology 90, 12-22.
22. Stambolic V, Ruel L & Woodgett JR (1996) Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 6, 1664-1668.
23. Hedgepeth CM, Conrad LJ, Zhang J, Huang HC, Lee VM & Klein PS (1997) Activation of the Wnt signaling pathway: a molecular mechanism for lithium action. Dev Biol 185, 82-91.
24. Shibamoto S, Higano K, Takada R, Ito F, Takeichi M & Takada S (1998) Cytoskeletal reorganization by soluble Wnt-3a protein signalling. Genes Cells 3, 659-670.
25. Durig J, Nuckel H, Huttmann A, Kruse E, Holler T, Halfmeyer K, Fuhrer A. Rudolph R, Kalhori N, Nusch A et al. (2003) Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia. Blood 101, 2748-2755.
26. Chtarbova S, Nimmrich I, Erdmann S, Herter P, Renner M, Kitajewski J & Muller O (2002) Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from beta-catenin activation. Biochem J 367, 723-728.
27. Fang Y, Lepont P, Fassett JT, Ford SP, Mubaidin A, Hamilton RT & Nilsen-Hamilton M (1999) Signaling between the placenta and the uterus involving the mitogen-regulated protein/proliferins. Endocrinology 140, 5239-5249.
28. Liu G, Loraine AE, Shigeta R, Cline M, Cheng J, Valmeekam V, Sun S, Kulp D & Siani-Rose MA (2003) NetAffx: Affymetrix probesets and annotations. Nucleic Acids Res 31, 82-86.
29. Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B & Clevers H (1997) Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science 275, 1784-1787.
30. Smith KJ, Johnson KA, Bryan TM, Hill DE, Markowitz S, Willson JK, Paraskeva C, Petersen GM, Hamilton SR & Vogelstein B (1993) The APC gene product in normal and tumor cells. Proc Natl Acad Sci USA 90, 2846-2850.
31. Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, Ilyas M, Bodmer WF, Moyer MP, Riecken EO, Buhr HJ & Hanski C (1999) Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci USA 96, 1603-1608.
32. Ni Z, Anini Y, Fang X, Mills G, Brubaker PL & Jin T (2003) Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells. J Biol Chem 278, 1380-1387.
33. Sampson EM, Haque ZK, Ku MC, Tevosian SG, Albanese C, Pestell RG, Paulson KE & Yee AS (2001) Negative regulation of the Wnt-beta-catenin pathway by the transcriptional represser HBP1. EMBO J 20, 4500-4511.
34. Thiele A, Wasner M, Muller C, Engeland K & Hauschildt S (2001) Regulation and possible function of beta-catenin in human monocytes. J Immunol 167, 6786-6793.
35. Garay-Rojas E, Harper M, Hraba-Renevey S & Kress M (1996) An apparent autocrine mechanism amplifies the dexamethasone- and retinoic acid-induced expression of mouse lipocalin-encoding gene 24p3. Gene 170, 173-180.
36. Berkowitz LA, Riabowol KT & Gilman MZ (1989) Multiple sequence elements of a single functional class are required for cyclic AMP responsiveness of the mouse c-fos promoter. Mol Cell Biol 9, 4272-4281.
37. Bleck B, Hohoff C, Binas B, Rustow B, Dixkens C, Hameister H, Borchers T & Spener F (1998) Cloning and chromosomal localisation of the murine epidermal-type fatty acid binding protein gene (Fabpe). Gene 215, 123-130.
38. Bedell MA, Copeland NG & Jenkins NA (1996) Multiple pathways for Steel regulation suggested by genomic and sequence analysis of the murine Steel gene. Genetics 142, 927-934.
39. Linzer DI & Mordacq JC (1987) Transcriptional regulation of proliferin gene expression in response to serum in transfected mouse cells. EMBO J 6, 2281-2288.
40. Tolvanen M, Vihinen M & Tuimala J (2003) Data mining for promoter sequences. In DNA Microarray Data Analysis (Tuimala J & Laine MM, eds), pp. 129-139. CSC - Scientific computing Ltd, Picaset Oy, Helsinki.