Expression of the nm23 homologues nm23-H4, nm23-H6, and nm23-H7 in human gastric and colon cancer

Journal of Pathology

Volumn 205, Issue 5, 2005, Pages 623-632

  Seifert, M ^a   Welter, C ^a   Mehraein, Y ^a   Seitz, G ^b  

^a SAARLAND UNIVERSITY   (Germany)

^b Municipal Hospital of Bamberg   (Germany)

Author keywords

Colon cancer; Gastric cancer; Nm23; Real time PCR

Indexed keywords

NUCLEOSIDE DIPHOSPHATE KINASE A;

APOPTOSIS; ARTICLE; CANCER CLASSIFICATION; CANCER STAGING; CARCINOGENESIS; COLON CANCER; COLON SURGERY; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE EXPRESSION; GENETIC REGULATION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; METASTASIS POTENTIAL; MULTIGENE FAMILY; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; STOMACH CARCINOMA; STOMACH SURGERY; TUMOR GROWTH;

ADENOCARCINOMA; COLONIC NEOPLASMS; GENE EXPRESSION; GENES, TUMOR SUPPRESSOR; HUMANS; IMMUNOENZYME TECHNIQUES; NUCLEOSIDE-DIPHOSPHATE KINASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; STOMACH NEOPLASMS;

EID: 17144369093     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1724     Document Type: Article

References (48)

1. Kauffman EC, Robinson VL, Stadler WM, Sokoloff MH, Rinker-Schaeffer CW. Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site. J Urol 2003; 169: 1122-1123.
2. Jaeger EB, Samant RS, Rinker-Schaeffer CW. Metastasis suppression in prostate cancer. Cancer Metastasis Rev 2001; 20 279-286.
3. Steeg PS. Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer 2003; 3: 55-63.
4. Steeg PS, Bevilacqua G, Kopper L, et al. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1988; 80: 200-204.
5. Hartsough MT, Steeg, PS. Nm23/nucleoside diphosphate kinase in human cancers. J Bioenerg Biomemb 2000; 32(3): 301-308.
6. Wallet V, Mutzel R, Troll H, et al. Dictyostelium nucleoside diphosphate kinase highly homologous to Nm23 and Awd proteins involved in mammalian tumor metastasis and Drosophila development. J Natl Cancer Inst 1990; 82: 1199-1202.
7. Biggs J, Hersperger E, Steeg PS, Liotta LA. Shearn A. A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Cell 1990; 63: 933-940.
8. Parks RE Jr, Agarwal RP. Nucleoside diphosphokinases. Enzymes 1973; 8: 307-333.
9. Stahl JA, Leone A, Rosengard AM, Porter L, King CR, Steeg PS. Identification of a second human nm23 gene, nm23-H2. Cancer Res 1991; 51: 445-449.
10. Backer JM, Mendola CE, Kovesdi I, et al. Chromosomal localization and nucleoside diphosphate kinase activity of human metastasis-suppressor genes NM23-1 and NM23-2. Oncogene 1993; 8 497-502.
11. Dooley S, Seib T, Engel M, et al. Isolation and characterization of the human genomic locus coding for the putative metastasis control gene nm23-H1. Hum Genet 1994; 93: 63-66.
12. Berberich SJ, Postel EH. PuF/NM23-H2/NDPK-B transactivates a human c-myc promoter-CAT gene via a functional nuclease hypersensitive element. Oncogene 1995; 10: 2343-2347.
13. Postel EH, Berberich SJ, Flint SJ, Ferrone CA. Human c-myc transcription factor PuF identified as nm23-H2 nucleoside diphosphate kinase, a candidate suppressor of tumor metastasis. Science 1993; 261: 478-480.
14. Postel EH, Ferrone CA. Nucleoside diphosphate kinase enzyme activity of NM23-H2/PuF is not required for its DNA binding and in vitro transcriptional functions. J Biol Chem 1994; 269: 8627-8630.
15. Roymans D, Willems R, Van Blockstaele DR, Slegers H. Nucleoside diphosphate kinase (NDPK/NM23) and the waltz with multiple partners: possible consequences in tumor metastasis. Clin Exp Metastasis 2002; 19: 465-476.
16. de la Rosa A, Williams RL, Steeg PS. Nm23/nucleoside diphosphate kinase: toward a structural and biochemical understanding of its biological functions. Bioessays 1995; 17: 53-62.
17. Kantor JD, McCormick B, Steeg PS, Zetter BR. Inhibition of cell motility after nm23 transfection of human and murine tumor cells. Cancer Res 1993; 53: 1971-1973.
18. Keim D, Hailat N, Melhem R, et al. Proliferation-related expression of p19/nm23 nucleoside diphosphate kinase. J Clin Invest 1992; 89: 919-924.
19. Nosaka K, Kawahara M, Masuda M, Satomi Y, Nishino H. Association of nucleoside diphosphate kinase nm23-H2 with human telomeres. Biochem Biophys Res Commun 1998; 243: 342-348.
20. Okabe KJ, Kasukabe T, Honma Y, Hayashi M, Hozumi M. Purification of a factor inhibiting differentiation from conditioned medium of nondifferentiating mouse myeloid leukemia cells. J Biol Chem 1988; 263: 10 994-10 999.
21. Venturelli D, Martinez R, Melotti P, et al. Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells. Proc Natl Acad Sci USA 1995; 92: 7435-7439.
22. Lacombe ML, Milon L, Munier A, Mehus JG, Lambeth DO. The human Nm23/nucleoside diphosphate kinases. J Bioenerg Biomembr 2000; 32: 247-258.
23. Wittekind CH, Meyer HJ, Bootz F (eds). International Union Against Cancer (UICC): TNM-Klassifikation maligner Tumoren (6th edn). Springer: Berlin, 2002.
24. Lauren P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma. Acta Pathol Microbiol Scand 1965; 64: 31-39.
25. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162: 156-159.
26. Lacombe ML, Sastre-Garau X, Lascu I, et al. Overexpression of nucleoside diphosphate kinase (Nm23) in solid tumours. Eur J Cancer 1991; 27: 1302-1307.
27. Martinez R, Venturelli D, Perrotti D, et al. Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family. Cancer Res 1997; 57: 1180-1187.
28. Hayer J, Engel M, Seifert M, Seitz G, Welter C. Overexpression of nm23-H4 RNA in colorectal and renal tumours. Anticancer Res 2001; 21(4A): 2821-2825.
29. Milon L, Meyer P, Chiadmi M, et al. The human nm23-H4 gene product is a mitochondrial nucleoside diphosphate kinase. J Biol Chem 2000; 275: 14 264-14 272.
30. Jacobus WE, Evans JJ. Nucleoside diphosphokinase of rat heart mitochondria: dual localization in matrix and intermembrane space. J Biol Chem 1977; 252: 4232-4241.
31. Muhonen WW, Lambeth DO. The compartmentation of nucleoside diphosphate kinase in mitochondria. Comp Biochem Physiol B Biochem Mol Biol 1995; 110: 211-223.
32. Pedersen PL. Coupling of adenosine triphosphate formation in mitochondria to the formation of nucleoside triphosphates: involvement of nucleoside diphosphokinase. J Biol Chem 1973; 248: 3956-3962.
33. Klingenberg M, Pfaff E. Metabolic control in mitochondria by adenine nucleotide translocation. Biochem Soc Symp 1968; 27: 105-122.
34. Thomson M. What are guanosine triphosphate-binding proteins doing in mitochondria? Biochim Biophys Acta 1998; 1403: 211-218.
35. Kowluru A. Adenine and guanine nucleotide-specific succinyl-CoA synthetases in the clonal beta-cell mitochondria: implications in the beta-cell high-energy phosphate metabolism in relation to physiological insulin secretion. Diabetologia 2001; 44: 89-94.
36. Krebs HA, Wiggins D. Phosphorylation of adenosine monophosphate in the mitochondrial matrix. Biochem J 1978; 174 297-301.
37. Voisine C, Craig EA, Zufall N, von Ahsen O, Pfanner N, Voos W. The protein import motor of mitochondria: unfolding and trapping of preproteins are distinct and separable functions of matrix Hsp70. Cell 1999; 97: 565-574.
38. Mehus JG, Deloukas P, Lambeth DO. NME6: a new member of the nm23/nucleoside diphosphate kinase gene family located on human chromosome 3p21.3. Hum Genet 1999; 104: 454-459.
39. Tsuiki H, Nitta M, Furuya A, et al. A novel human nucleoside diphosphate (NDP) kinase, Nm23-H6, localizes in mitochondria and affects cytokinesis. J Cell Biochem 1999; 76: 254-269.
40. Xu J, Liu LZ, Deng XF, et al. The enzymatic activity of Drosophila AWD/NDP kinase is necessary but not sufficient for its biological function. Dev Biol 1996; 177: 544-557.
41. Otero AS. Copurification of vimentin, energy metabolism enzymes, and a MER5 homolog with nucleoside diphosphate kinase: identification of tissue-specific interactions. J Biol Chem 1997; 272: 14 690-14 694.
42. Pinon VP, Millot G, Munier A, et al. Cytoskeletal association of the A and B nucleoside diphosphate kinases of interphasic but not mitotic human carcinoma cell lines: specific nuclear localization of the B subunit. Exp Cell Res 1999; 246: 355-367.
43. Reymond A, Volorio S, Merla G, et al. Evidence for interaction between human PRUNE and nm23-H1 NDPKinase. Oncogene 1999; 18: 7244-7252.
44. Engel M, Seifert M, Theisinger B, Seyfert U, Welter C. Glyceraldehyde-3-phosphate dehydrogenase and Nm23-H1/nucleoside diphosphate kinase A: two old enzymes combine for the novel Nm23 protein phosphotransferase function. J Biol Chem 1998; 273: 20 058-20 065.
45. Kowluru A, Tannous M, Chen HQ. Localization and characterization of the mitochondrial isoform of the nucleoside diphosphate kinase in the pancreatic beta cell: evidence for its complexation with mitochondrial succinyl-CoA synthetase. Arch Biochem Biophys 2002; 398: 160-169.
46. Green D, Kroemer G. The central executioners of apoptosis: caspases or mitochondria? Trends Cell Biol 1998; 8: 267-271.
47. Marzo I, Brenner C, Zamzami N, et al. Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis. Science 1998; 281: 2027-2031.
48. Shimizu S, Narita M, Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999; 399: 483-487.