Deficiency in immunoglobulin G2 antibodies against staphylococcal enterotoxin C1 defines a subgroup of patients with atopic dermatitis

Clinical and Experimental Allergy

Volumn 35, Issue 3, 2005, Pages 274-281

  Mrabet Dahbi, S ^a   Breuer, K ^b   Klotz, M ^a   Herz, U ^a   Heeg, K ^a   Werfel, T ^b   Renz, Harald ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Adaptive immunity; Atopic dermatitis; IgG subclass; Immunodeficiency; Staphylococcal enterotoxins; Superantigens

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G4; PNEUMOCOCCUS POLYSACCHARIDE; STAPHYLOCOCCUS ENTEROTOXIN; STAPHYLOCOCCUS ENTEROTOXIN B; STAPHYLOCOCCUS ENTEROTOXIN C1; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; ATOPIC DERMATITIS; BACTERIAL COLONIZATION; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HUMAN; HUMORAL IMMUNE DEFICIENCY; IMMUNE SYSTEM; IMMUNITY; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PRIORITY JOURNAL; SCORING SYSTEM; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

ADOLESCENT; ADULT; AGED; ANTIBODIES, ANTI-IDIOTYPIC; CASE-CONTROL STUDIES; CELLS, CULTURED; CYTOKINES; DERMATITIS, ATOPIC; ENTEROTOXINS; FEMALE; HUMANS; IMMUNOGLOBULIN G; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; POLYSACCHARIDES, BACTERIAL; STATISTICS, NONPARAMETRIC; SUPERANTIGENS; TH2 CELLS;

EID: 17144367239     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2005.02192.x     Document Type: Article

References (34)

1. Leung DY, David TJ, Cambridge GC et al. Infection in atopic dermatitis. Curr Opin Pediatr 2003; 15:399-404.
2. Hanifin JM, Rogge JL, David TJ et al. Staphylococcal infections in patients with atopic dermatitis. Arch Dermatol 1977; 113:1383-6.
3. David TJ, Cambridge GC, Monti G, Tonetto P, Mostert M, Oggero R. Bacterial infection and atopic eczema. Arch Dis Child 1986; 61:20-3.
4. Monti G, Tonetto P, Mostert M, Oggero R. Staphylococcus aureus skin colonization in infants with atopic dermatitis. Dermatology 1996; 193:83-7.
5. Williams RE, Gibson AG, Aitchison TC et al. Assessment of a contact-plate sampling technique and subsequent quantitative bacterial studies in atopic dermatitis. Br J Dermatol 1990; 123:493-501.
6. Bhakdi S, Tranum-Jensen J. Alpha-toxin of Staphylococcus aureus. Microbiol Rev 1991; 55:733-51.
7. Hoeger PH, Lenz W, Boutonnier A et al. Staphylococcal skin colonization in children with atopic dermatitis: prevalence, persistence, and transmission of toxigenic and nontoxigenic strains. J Infect Dis 1992; 165:1064-8.
8. Leung DY, Harbeck R, Bina P et al. Presence of IgE antibodies to staphylococcal exotoxins on the skin of patients with atopic dermatitis. J Clin Invest 1993; 92:1374-80.
9. McFadden JP, Noble WC, Camp RD, Michie CA, Davis T. Superantigenic exotoxin-secreting potential of staphylococci isolated from atopic eczematous skin. Br J Dermatol 1993; 128:631-2.
10. Michie CA, Davis T. Atopic dermatitis and Staphylococcal superantigens. Lancet 1996; 347:324.
11. Bunikowski R, Mielke ME, Skarabis H et al. Evidence for a disease-promoting effect of Staphylococcus aureus-derived exotoxins in atopic dermatitis. J Allergy Clin Immunol 2000; 105:814-9.
12. Bunikowski R, Mielke M, Skarabis H et al. Prevalence and role of serum IgE antibodies to the Staphylococcus aureus-derived superantigens SEA and SEB in children with atopic dermatitis. J Allergy Clin Immunol 1999; 103:119-24.
13. Breuer K, Häussler S, Kapp A, Werfel T. Staphylococcus aureus: colonizing features and influence of an antibacterial treatment in adults with atopic dermatitis. Br J Dermatol 2002; 147:55-61.
14. Breuer K, Wittmann M, Bosche B, Kapp A, Werfel T. Severe atopic dermatitis is associated with sensitization to staphylococcal enterotoxin B (SEB). Allergy 2000; 55:551-5.
15. Sampson HA, Skov L, Olsen JV et al. Pathogenesis of eczema. Clin Exp Allergy 1990; 20:459-67.
16. Saloga J, Leung DY, Reardon C, Giorno RC, Born W, Gelfand EW. Cutaneous exposure to the superantigen staphylococcal enterotoxin B elicits a T-cell-dependent inflammatory response. J Invest Dermatol 1996; 106:982-8.
17. Skov L, Olsen JV, Giorno R, Schlievert PM, Baadsgaard O, Leung DY. Application of Staphylococcal enterotoxin B on normal and atopic skin induces up-regulation of T cells by a superantigen-mediated mechanism. J Allergy Clin Immunol 2000; 105:820-6.
18. Ong PY, Ohtake T, Brandt C et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med 2002; 347:1151-60.
19. Nomura I, Goleva E, Howell MD, Hamid QA et al. J Immunol 2003; 171:3262-9.
20. Nissen D, Pedersen LJ, Skov PS et al. IgE-binding components of staphylococcal enterotoxins in patients with atopic dermatitis. Ann Allergy Asthma Immunol 1997; 79:403-8.
21. Moncef Z. Antibodies. Encyclopedia of life sciences. London; Nature Publishing Group/Macmillan Reference Ltd, 2002; 1.
22. Hanifin J, Rajka G. Diagnostic features of atopic dermatitis. Acta Derma Venerol 1980; 92:44-7.
23. Stalder JF, Taieb A, Atherton DJ et al. Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993; 186:23-31.
24. Campbell DE, Kemp AS. Production of antibodies to staphylococcal superantigens in atopic dermatitis. Arch Dis Child 1998; 79:400-4.
25. Siber GR, Schur PH, Aisenberg AC, Weitzman SA, Schiffman G. Correlation between serum IgG-2 concentrations and the antibody response to bacterial polysaccharide antigens. N Engl J Med 1980; 303:178-82.
26. Bredius RG, de Vries CE, Troelstra A et al. Phagocytosis of Staphylococcus aureus and Haemophilus influenzae type B opsonized with polyclonal human IgG1 and IgG2 antibodies. Functional hFc gamma RIIa polymorphism to IgG2. J Immunol 1993; 151:1463-72.
27. Yoshioka T, Hikita I, Matsutani T et al. DS-Nh as an experimental model of atopic dermatitis induced by Staphylococcus aureus producing staphylococcal enterotoxin C. Immunology 2003; 108:562-9.
28. Persson MA, Brown SE, Steward MW et al. IgG subclass-associated affinity differences of specific antibodies in humans. J Immunol 1988; 140:3875-9.
29. Pan Q, Hammarstrom L. Molecular basis of IgG subclass deficiency. Immunol Rev 2000; 178:99-110.
30. Kawano Y, Noma T, Yata J. Regulation of human IgG subclass production by cytokines. IFN-gamma and IL-6 act antagonistically in the induction of human IgG1 but additively in the induction of IgG2. J Immunol 1994; 153:4948-58.
31. Bendelac A, Hunziker RD, Lantz O. Increased interleukin 4 and immunoglobulin E production in transgenic mice overexpressing NK1 T cells. J Exp Med 1996; 184:1285-93.
32. Aalberse RC, van der Gaag R, van Leeuwen J. Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. J Immunol 1983; 130:722-6.
33. Chi YI, Sadler I, Jablonski LM et al. Zinc-mediated dimerization and its effect on activity and conformation of staphylococcal enterotoxin type C. J Biol Chem 2002; 277:22839-46.
34. Epstein MM, Gruskay F. Selective deficiency in pneumococcal antibody response in children with recurrent infections. Ann Allergy Asthma Immunol 1995; 75:125-31.