Endothelin receptor antagonism attenuates cardiomyocyte apoptosis after induction of ischemia in rats

Scandinavian Cardiovascular Journal

Volumn 36, Issue 2, 2002, Pages 108-116

  Øie, Erik ^a   Clausen, Ole Petter F ^b   Yndestad, Arne ^a   Grøgaard, Haakon K ^a   Attramadal, Håvard ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Apoptosis; Endothelin; Gene expression; Myocardial ischemia

Indexed keywords

BOSENTAN; DNA FRAGMENT; DRUG VEHICLE; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR ANTAGONIST; FAS ANTIGEN; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; PROTEIN BAX; PROTEIN P53;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENUATION; CELL LOSS; CELL VIABILITY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DNA DEGRADATION; DNA DETERMINATION; GENE ACTIVATION; GENE EXPRESSION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE; HEART MUSCLE; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; IMMUNOHISTOCHEMISTRY; MALE; NICK END LABELING; NONHUMAN; NORTHERN BLOTTING; NUCLEOSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RISK ASSESSMENT;

ANIMALS; APOPTOSIS; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; HEART FAILURE, CONGESTIVE; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; RATS; RATS, WISTAR; RECEPTORS, ENDOTHELIN; SULFONAMIDES; VENTRICULAR REMODELING;

EID: 17044448409     PISSN: 14017431     EISSN: None     Source Type: Journal    
DOI: 10.1080/140174302753675401     Document Type: Article

References (26)

1. Apoptosis in myocytes in end-stage heart failure
2. Apoptosis in the failing human heart
3. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats
4. Apoptosis in human acute myocardial infarction
5. Side-to-side slippage of myocytes participates in ventricular wall remodeling acutely after myocardial infarction in rats
6. Apoptosis and myocardial infarction
7. Left ventricular end-systolic volume as the major determinant of survival after recovery from myocardial infarction
8. Why does the myocardium fail? Insights from basic science
9. ET-receptor antagonism, myocardial gene expression, and ventricular remodeling during CHF in rats
10. Chronic endothelin receptor blockade attenuates progressive ventricular dilation and improves cardiac function in rats with myocardial infarction: Possible involvement of myocardial endothelin system in ventricular remodeling
11. Lack of nuclear apoptosis in cardiomyocytes and increased endothelin-1 levels in a rat heart model of myocardial stunning
12. Effect of non-selective endothelin blockade, TAK-044, on the ischemic cellular injury of rat heart
13. Transient, isopeptide-specific induction of myocardial endothelin-1 mRNA during congestive heart failure in rats
14. Apoptosis and expression of Bax, Bcl-x, and Bcl-2 apoptotic regulatory proteins in colorectal carcinomas, and association with p53 genotype/phenotype
15. "Apoptotic" myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation: Analysis by immunogold electron microscopy combined with in situ nick end-labeling
16. Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: Not apoptosis but DNA repair
17. Biochemical evidence for programmed cell death in rabbit uterine epithelium
18. Induction of apoptosis in fibroblasts by c-myc protein
19. Plasma endothelin determination as a prognostic indicator of 1-year mortality after acute myocardial infarction
20. Prognostic impact of big endothelin-1 plasma concentrations compared with invasive hemodynamic evaluation in severe heart failure
21. Cardiac anatomy and ventricular loading after myocardial infarction
22. p53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes
23. Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53
24. Hypothesis: Apoptosis may be a mechanism for the transition to heart failure with chronic pressure overload
25. Effects of ACE inhibition on cardiomyocyte apoptosis in dogs with heart failure
26. + exchanger: A potential therapeutic target for the prevention of myocardial ischaemic and reperfusion injury and attenuation of postinfarction heart failure