Effects of antithrombin III on myeloperoxidase activity, superoxide dismutase activity, and malondialdehyde levels and histopathological findings after spinal cord injury in the rat

Neurosurgery

Volumn 56, Issue 4, 2005, Pages 828-835

  Erman, Tahsin ^a   Yildiz, M Şule ^a   Göçer, A Iskender ^a   Zorludemir, Suzan ^b   Demirhindi, Hakan ^b   Tuna, Metin ^a  

^a CUKUROVA UNIVERSITY FACULTY OF MEDICINE   (Turkey)

^b CUKUROVA UNIVERSITY   (Turkey)

Author keywords

Activated leukocyte; Antithrombin III; Malondialdehyde; Myeloperoxidase; Rat; Spinal cord injury; Superoxide dismutase

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN III CONCENTRATE; MALONALDEHYDE; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE;

ANEURYSM CLIP; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; HISTOLOGY; LAMINECTOMY; LEUKOCYTE ACTIVATION; MALE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; SPINAL CORD INJURY; THORACIC SPINAL CORD;

ANIMALS; ANTITHROMBIN III; DISEASE MODELS, ANIMAL; MALE; MALONDIALDEHYDE; PEROXIDASE; RATS; RATS, WISTAR; SPINAL CORD COMPRESSION; SPINAL CORD INJURIES; SUPEROXIDE DISMUTASE;

EID: 17044439178     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000157004.19427.35     Document Type: Article

References (52)

1. Akopov S, Sercombe R, Seylaz J: Cerebrovascular reactivity: Role of endothelium/platelet/leukocyte interactions. Cerebrovasc Brain Metab Rev 8:11-94, 1996.
2. Anderson DK, Demediuk P, Saunders RD, Dugan LL, Means ED, Horrocks LA: Spinal cord injury and protection. Ann Emerg Med 14:816-821, 1985.
3. Chen CJ, Liao SL, Chen WY, Hong JS, Kuo JS: Cerebral ischemia/ reperfusion injury in rat brain: Effects of naloxone. Neuroreport 12:1245-1249, 2001.
4. Coles JC, Ahmed SN, Mehta HU: Role of free radical scavenger in protection of spinal cord during ischemia. Ann Thorac Surg 41:551-556, 1986.
5. Demopoulos GB, Flamm ES, Pietronigro DD, Seligman ML: The free radical pathology and the microcirculation in the major central nervous system disorders. Acta Physiol Scand Suppl 492:91-119, 1980.
6. Dickneite G: Antithrombin III in animal models of sepsis and organ failure. Semin Thromb Hemost 24:61-63, 1998.
7. Dickneite G, Leithauser B: Influence of antithrombin III on coagulation and inflammation in porcine septic shock. Arterioscler Thromb Vasc Biol 19:1566-1572, 1999.
8. Ducker TB, Kindt GW, Kempe LG: Pathological findings in acute experimental spinal cord trauma. J Neurosurg 35:700-708, 1971.
9. Eisele B, Lamy M: Clinical experience with antithrombin III concentrates in critically ill patients with sepsis and multiple organ failure. Semin Thromb Hemost 24:71-80, 1998.
10. Faden AI: Neurotoxic versus neuroprotective actions of endogenous opioid peptides: Implications for treatment of CNS injury. NIDA Res Monogr 163:318-330, 1996.
11. Feigin I: The pathological changes produced by focal cerebral anoxia. Res Publ Assoc Res Nerv Ment Dis 41:23-29, 1966.
12. Glowick SP, Kaplan SD: Method in Enzymology. New York, Academic Press, 1995, pp 769-782.
13. Harada N, Okajima K, Kushimoto S, Isobe H, Tanaka K: Antithrombin reduces ischemia/reperfusion injury of rat liver by increasing the hepatic level of prostacyclin. Blood 93:157-164, 1999.
14. Harlan JM: Consequences of leukocytes-vessel wall interactions in inflammatory and immune reactions. Semin Thromb Hemost 13:425-433, 1987.
15. Hoffmann JN, Vollmar B, Römisch J, Inthorn D, Schildberg FW, Menger MD: Antithrombin effects on endotoxin-induced microcirculatory disorders are mediated mainly by its interaction with microvascular endothelium. Crit Care Med 30:218-225, 2002.
16. Horie S, Ishii H, Kazama M: Heparin-like glycosaminoglycans is a receptor for antithrombin III-dependent prostacyclin production in human endothelial cells. Thromb Res 59:895-904, 1990.
17. +2 ATPase activity, lipid peroxidation and ultrastructural findings following experimental spinal cord injury with and without intravenous methylprednisolone treatment. Neurosurg Rev 18:35-44, 1995.
18. Ilias W, List W, Decruyenaere J, Lignian H, Knaub S, Schindel F, Keinecke HO, Heinrichs H, Thijs LG: Antithrombin-III in patients with severe sepsis: A pharmacokinetic study. Intensive Care Med 26:704-715, 2000.
19. Inthorn D, Hoffmann JN, Hartl WH, Mühlbayer D, Jochum M: Effect of antithrombin III supplement on inflammatory response in patients with severe sepsis. Shock 10:90-96, 1998.
20. Isobe H, Okajima K, Uchiba M, Harada N, Okabe H: Antithrombin prevents endotoxin-induced hypotension by inhibiting the induction of nitric oxide synthase in rats. Blood 99:1638-1645, 2002.
21. Lopez-Neblina F, Toledo-Pereyra LH, Mirmiran R, Paez-Rollys AJ: Time dependence of Na-nitroprusside administration in the prevention of neutrophil infiltration in the rat ischemic kidney. Transplantation 61:179-183, 1996.
22. Mavrommatis AC, Theodoridis T, Orfanidou A: Coagulation system and platelets are fully activated in uncomplicated sepsis. Crit Care Med 28:451-457, 2000.
23. Means ED, Anderson DK: The pathophysiology of acute spinal cord injury, in Davidoff RA (ed): Handbook of the Spinal Cord. New York, Marcel Dekker, 1987, pp 366-387.
24. Moncada S, Vane JR: The role of prostacyclin in vascular tissue. Fed Proc 38:66-71, 1979.
25. Nakauchi K, Ikata T, Katoh S, Hamada Y, Tsuchiya K, Fukuzawa K: Effect of lecithinized superoxide dismutase on rat spinal cord injury. J Neurotrauma 13:573-582, 1996.
26. Nishijima K, Kiryu J, Tsujikawa A, Honjo M, Nonaka A, Yamashiro K, Kamizuru H, Ieki Y, Tanihara H, Honda Y, Ogura Y: Inhibitory effects of antithrombin III on interactions between blood cells and endothelial cells during retinal ischemia-reperfusion injury. Invest Ophthalmol Vis Sci 44:332-341, 2003.
27. Ohkawa H, Ohishi N, Yagi K: Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95:351-358, 1979.
28. Okajima K: Regulation of inflammatory responses by natural anticoagulants. Immunol Rev 184:258-274, 2001.
29. Okajima K, Uchiba M: The anti-inflammatory properties of antithrombin-III: New therapeutic implications. Semin Thromb Hemost 24:27-32, 1998.
30. Ostrovsky I, Woodmann RC, Payne D, Teoh D, Kubes P: Antithrombin III prevents and rapidly reverses leukocyte recruitment in ischemia/ reperfusion. Circulation 96:2302-2310, 1997.
31. Özden A, Sarioglu A, Demirkan NÇ, Bilgihan A, Düzcan E: Antithrombin III reduces renal ischemia-reperfusion injury in rats. Res Exp Med 200:195-203, 2001.
32. Penner JA: Antithrombin's role in the management of trauma. Biomed Prog 11:7-11, 1998.
33. Rivlin AS, Tator CH: Effect of duration of acute spinal cord compression in a new acute cord injury in the rat. Surg Neurol 10:39-43, 1978.
34. Salvatierra A, Guerrero R, Rodriguez M, Alvarez A, Soriano F, Lopez-Pedrera R, Ramirez R, Carracedo J, Lopez-Rubio F, Lopez-Pujol J, Velasco F: Antithrombin III prevents early pulmonary dysfunction after lung transplantation in the dog. Circulation 104:2975-2980, 2001.
35. Savage B, Saldivar E, Ruggeri ZM: Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von Willebrand factor. Cell 84:289-297, 1996.
36. Seligman ML, Flamm ES, Goldstein BD, Poser RG, Demopoulos HB, Ransohoff J: Spectrofluorescent detection of malonyldialdehyde as a measure of lipid free radical damage in response to ethanol potentiation of spinal cord trauma. Lipids 12:945-950, 1977.
37. Sharma HS, Olsson Y: Edema formation and cellular alterations following spinal cord injury in rat and their modification with p-chlorophenylalanine. Acta Neuropathol (Berl) 79:604-610, 1990.
38. Sharma HS, Olsson Y, Nyberg F: Influence of dynorphin A antibodies on the formation of edema and cell changes in spinal cord trauma. Prog Brain Res 104:401-416, 1995.
39. Szabo ME, Droy-Lefaix MT, Doly M, Carre C, Braquet P: Ischemia and reperfusion-induced histologic changes in the rat retina: Demonstration of a free radical-mediated mechanism. Invest Ophthalmol Vis Sci 32:1471-1478, 1991.
40. Taoka Y, Okajima K: Spinal cord injury in the rat. Prog Neurobiol 56:341-358, 1998.
41. Taoka Y, Okajima K: Role of leukocytes in spinal cord injury in the rat. J Neurotrauma 17:219-229, 2000.
42. Taoka Y, Okajima K, Murakami K, Johno M, Naruo M: Role of neutrophil elastase in compression-induced spinal cord injury in rats. Brain Res 799:264-269, 1998.
43. Taoka Y, Okajima K, Uchiba M, Murakami K, Kushimoto S, Johno M, Naruo M, Okabe H, Takatsuki K: Role of neutrophils in spinal cord injury in the rat. Neuroscience 79:1177-1182, 1997.
44. Tateson JE, Moncada S, Vane JR: Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets. Prostaglandins 13:389-397, 1977.
45. Tekin K, Aytekin FO, Özden A, Bilgihan A, Erdem E, Sungurtekin U, Güney Y: Antithrombin-III prevents deleterious effect of remote ischemia-reperfusion injury on healing of colonic anastomoses. Am J Surg 184:160-165, 2002.
46. Uchiba M, Okajima K: Antithrombin-III (AT-III) prevents LPS-induced pulmonary vascular injury: Novel biological activity of AT-III. Semin Thromb Hemost 23:583-590, 1997.
47. Uchiba M, Okajima K, Murakami K: Effects of various doses of antithrombin-III on endotoxin-induced endothelial cell injury and coagulation abnormalities in rats. Thromb Res 89:233-241, 1998.
48. Uchiba M, Okajima K, Murakami K, Okabe H, Takatsuki K: Effects of antithrombin-III (AT-III) and Trp49-modified AT III on plasma level of 6-keto-PGF1α in rats. Thromb Res 80:201-208, 1995.
49. Uchiba M, Okajima K, Murakami K, Okabe H, Takatsuki K: Attenuation of endotoxin-induced pulmonary vascular injury by antithrombin III. Am J Physiol 270[Suppl 6]:L921-L930, 1996.
50. Waydhas C, Nast-Kolb D, Gippner-Steppert C, Trupka A, Pfundstein C, Schweiberer L, Jochum M: High-dose antithrombin-III treatment of severely injured patients: Results of a prospective study. J Trauma 45:931-940, 1998.
51. Xu J, Hsu CY, Liu TH, Hogan EL, Perot E, Tai H: Leukotriene B4 release and polymorphonuclear cell infiltration in spinal cord injury. J Neurochem 55:907-912, 1990.
52. Yamauchi T, Umeda F, Inoguchi T, Nawata H: Antithrombin-III stimulates prostacyclin production by cultured aortic endothelial cells. Biochem Biophys Res Commun 163:404-1411, 1989.