Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children

Journal of Infectious Diseases

Volumn 191, Issue 8, 2005, Pages 1233-1238

  Moormann, Ann M ^a   Chelimo, Kiprotich ^f   Sumba, Odada P ^f   Lutzke, Mary L ^b,g   Ploutz Snyder, Robert ^d   Newton, Duane ^c   Kazura, James ^a   Rochford, Rosemary ^e  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d SUNY UPSTATE MEDICAL UNIVERSITY   (United States)

^e State University of New York Upstate Medical University: College of Medicine   (United States)

^f KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^g Kent County Health Department   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; BURKITT LYMPHOMA; CANCER RISK; CHILD; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE TRANSMISSION; DNA EXTRACTION; ENDEMIC DISEASE; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; HYPOTHESIS; KENYA; MAJOR CLINICAL STUDY; MALARIA; PATHOGENESIS; PERSISTENT VIRUS INFECTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE; UNITED STATES; VIRUS INFECTION; VIRUS LOAD;

ADOLESCENT; ADULT; AGE DISTRIBUTION; CHILD; CHILD, PRESCHOOL; EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; INFANT; KENYA; MALARIA; UNITED STATES; VIRAL LOAD;

EID: 17044436199     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/428910     Document Type: Article

References (37)

1. de-The G, Geser A, Day NE, et al. Epidemiological evidence for causal relationship between Epstein-Barr virus and Burkitt's lymphoma from Ugandan prospective study. Nature 1978; 274:756-61.
2. zur Hausen H, Schulte-Holthausen H, Klein G, et al. EBV DNA in biopsies of Burkitt tumours and anaplastic carcinomas of the nasopharynx. Nature 1970; 228:1056-8.
3. Reedman BM, Klein G, Pope JH, et al. Epstein-Barr virus-associated complement-fixing and nuclear antigens in Burkitt lymphoma biopsies. Int J Cancer 1974; 13:755-63.
4. de-The G. Is Burkitt's lymphoma related to perinatal infection by Epstein-Barr virus? Lancet 1977; 1:335-8.
5. Klein G. Epstein-Barr virus, malaria and Burkitt's lymphoma. Scand J Infect Dis Suppl 1982; 36:15-23.
6. Morrow RH. Epidemiological evidence for the role of falciparum malaria in the pathogenesis of Burkitt's lymphoma. In: Lenoir G, O'Connor G, Olweny C, eds. Burkitt's lymphoma: a human cancer model. Vol. 60. Lyons: IARC Press, 1985:177-85.
7. Lam KM, Syed N, Whittle H, Crawford DH. Circulating Epstein-Barr virus-carrying B cells in acute malaria. Lancet 1991; 337:876-8.
8. Miyashita EM, Yang B, Babcock GJ, Thorley-Lawson DA. Identification of the site of Epstein-Barr virus persistence in vivo as a resting B cell. J Virol 1997; 71:4882-91.
9. Wadowsky RM, Laus S, Green M, Webber SA, Rowe D. Measurement of Epstein-Barr virus DNA loads in whole blood and plasma by TaqMan PCR and in peripheral blood lymphocytes by competitive PCR. J Clin Microbiol 2003; 41:5245-9.
10. Rowe DT, Qu L, Reyes J, et al. Use of quantitative competitive PCR to measure Epstein-Barr virus genome load in the peripheral blood of pediatric transplant patients with lymphoproliferative disorders. J Clin Microbiol 1997; 35:1612-5.
11. Khan G, Miyashita EM, Yang B, Babcock GJ, Thorley-Lawson DA. Is EBV persistence in vivo a model for B cell homeostasis? Immunity 1996; 5:173-9.
12. Stevens SJ, Verschuuren EA, Pronk I, et al. Frequent monitoring of Epstein-Barr virus DNA load in unfractionated whole blood is essential for early detection of posttransplant lymphoproliferative disease in high-risk patients. Blood 2001; 97:1165-71.
13. Ling PD, Vilchez RA, Keitel WA, et al. Epstein-Barr virus DNA loads in adult human immunodeficiency virus type 1-infected patients receiving highly active antiretroviral therapy. Clin Infect Dis 2003; 37:1244-9.
14. Snow RW, Omumbo JA, Lowe B, et al. Relation between severe malaria morbidity in children and level of Plasmodium falciparum transmission in Africa. Lancet 1997; 349:1650-4.
15. Marsh K, Snow RW. Malaria transmission and morbidity. Parassitologia 1999; 41:241-6.
16. Mbogo CN, Snow RW, Khamala CP, et al. Relationships between Plasmodium falciparum transmission by vector populations and the incidence of severe disease at nine sites on the Kenyan coast. Am J Trop Med Hyg 1995; 52:201-6.
17. Snow RW, Gouws E, Omumbo J, et al. Models to predict the intensity of Plasmodium falciparum transmission: applications to the burden of disease in Kenya. Trans R Soc Trop Med Hyg 1998; 92:601-6.
18. Kimura H, Morita M, Yabuta Y, et al. Quantitative analysis of Epstein-Barr virus load by using a real-time PCR assay. J Clin Microbiol 1999; 37:132-6.
19. Snow RW, Nahlen B, Palmer A, Donnelly CA, Gupta S, Marsh K. Risk of severe malaria among African infants: direct evidence of clinical protection during early infancy. J Infect Dis 1998; 177:819-22.
20. Haddow AJ. Age incidence in Burkitt's lymphoma syndrome. East Afr Med J 1964; 41:1-6.
21. Mwanda WO. Burkitt's lymphoma: geographical, demographical and clinical characteristics in Kenya. Nairobi: Department of Hematology and Blood Transfusion, University of Nairobi, 2000:453.
22. Rose C, Green M, Webber S, Ellis D, Reyes J, Rowe D. Pediatric solid-organ transplant recipients carry chronic loads of Epstein-Barr virus exclusively in the immunoglobulin D-negative B-cell compartment. J Clin Microbiol 2001; 39:1407-15.
23. Greenwood BM. Possible role of a B-cell mitogen in hypergammaglobulinaemia in malaria and trypanosomiasis. Lancet 1974; 1:435-6.
24. Whittle HC, Brown J, Marsh K, Blackman M, Jobe O, Shenton F. The effects of Plasmodium falciparum malaria on immune control of B lymphocytes in Gambian children. Clin Exp Immunol 1990; 80:213-8.
25. Wagner HJ, Wessel M, Jabs W, et al. Patients at risk for development of posttransplant lymphoproliferative disorder: plasma versus peripheral blood mononuclear cells as material for quantification of Epstein-Barr viral load by using real-time quantitative polymerase chain reaction. Transplantation 2001; 72:1012-9.
26. Riddler SA, Breinig MC, McKnight JLC. Increased levels of circulating Epstein-Barr virus (EBV)-infected lymphocytes and decreased EBV nuclear antigen antibody responses are associated with the development of posttransplant lymphoproliferative disease in solid-organ transplant recipients. Blood 1994; 84:972-84.
27. Rowe DT, Webber S, Schauer EM, Reyes J, Green M. Epstein-Barr virus load monitoring: its role in the prevention and management of post-transplant lymphoproliferative disease. Transpl Infect Dis 2001; 3:79-87.
28. Stevens SJ, Pronk I, Middeldorp JM. Toward standardization of Epstein-Barr virus DNA load monitoring: unfractionated whole blood as preferred clinical specimen. J Clin Microbiol 2001; 39:1211-6.
29. Henle G, Henle W, Clifford P, et al. Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups. J Natl Cancer Inst 1969; 43:1147-57.
30. Biggar RJ, Henle G, Bocker J, Lennette ET, Fleisher G, Henle W. Primary Epstein-Barr virus infections in African infants. II. Clinical and serological observations during seroconversion. Int J Cancer 1978; 22:244-50.
31. Berger C, Day P, Meier G, Zingg W, Bossart W, Nadal D. Dynamics of Epstein-Barr virus DNA levels in serum during EBV-associated disease. J Med Virol 2001; 64:505-12.
32. Larouche C, Drouet EB, Brousset P, et al. Measurement by the polymerase chain reaction of the Epstein-Barr virus load in infectious mononucleosis and AIDS-related non-Hodgkin's lymphomas. J Med Virol 1995; 46:66-74.
33. Mwanda OW, Rochford R, Moormann AM, Macneil A, Whalen C, Wilson ML. Burkitt's Lymphoma in Kenya: geographical, age, gender and ethnic distibution. East Afr Med J 2004; 81(Suppl 8):S68-77.
34. Young LS, Yao QY, Rooney CM, et al. New type B isolates of Epstein-Barr virus from Burkitt's lymphoma and from normal individuals in endemic areas. J Gen Virol 1987; 68:2853-62.
35. Habeshaw G, Yao QY, Bell AI, Morton D, Rickinson AB. Epstein-Barr virus nuclear antigen 1 sequences in endemic and sporadic Burkitt's lymphoma reflect virus strains prevalent in different geographic areas. J Virol 1999; 73:965-75.
36. Haddow AJ. An improved map for the study of Burkitt's lymphoma syndrome in Africa. East Afr Med J 1963; 40:429-32.
37. Payne D. Use and limitations of light microscopy for diagnosing malaria at the primary health care level. Bull WHO 1988; 66:621-6.