Chemoenzymatic asymmetric total synthesis of phosphodiesterase inhibitors: Preparation of a polycyclic pyrazolo[3,4-d]pyrimidine from an acylnitroso Diels-Alder cycloadduct-derived aminocyclopentenol

Journal of Organic Chemistry

Volumn 70, Issue 7, 2005, Pages 2824-2827

  Jiang, May Xiao Wu ^a   Warshakoon, Namal C ^a   Miller, Marvin J ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CATALYSIS; CONDENSATION; HYDROGENATION; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

CHEMOENZYMATIC ASYMMETRIC TOTAL SYNTHESIS; CYCLIZATION; ENANTIOMERS; PHOSPHODIESTERASE INHIBITORS;

ENZYME INHIBITION;

5,6A,7,8,9,9A HEXAHYDRO 5 PHENYL 1 (PHENYLMETHYL)CYCLOPENT[4,5]IMIDAZO[1,2 A]PYRAZOLO[4,3 E]PYRIMIDIN 4(1H) ONE; PHOSPHODIESTERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CYCLIZATION; CYCLOADDITION; DIELS ALDER REACTION; DRUG SYNTHESIS; ENANTIOSELECTIVITY; HYDROGENATION; POLYMERIZATION; SEPARATION TECHNIQUE;

CYCLOPENTANES; ENZYMES; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHODIESTERASE INHIBITORS; PYRAZOLES; PYRIMIDINES; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, INFRARED;

EID: 17044414082     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo0484070     Document Type: Article

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