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The unreacted alkene of 5a-b is deactivated towards epoxidation by the electron-withdrawing acetoxymethylene substituent.
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18
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0042321336
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note
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The unreacted 3S,6R,7R-diastereomer 5b was easily separated from cyclization product 6a and was isolated in 30% yield.
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0042822515
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2, -20°C (89%);
-
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24
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0041319813
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note
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(b) TBDMSCl, imidazole, DMF (100%).
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