Effects of (±)-huprine Y and (±)-huprine Z, two new anticholinesterasic drugs, on muscarinic receptors

Neuroscience Letters

Volumn 379, Issue 2, 2005, Pages 106-109

  Alcala M M ^a   Maderuelo, A ^b   Vivas, N M ^a   Camps, P ^b   Munoz Torrero D ^b   Clos, M V ^a   Badia, A ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

( ) Huprine Y; ( ) Huprine Z; AChE inhibitor; Alzheimer's disease; Huperzine A; Muscarinic receptors; Tacrine

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; CHOLINESTERASE INHIBITOR; HUPRINE Y; HUPRINE Z; INOSITOL PHOSPHATE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; MUSCARINIC M1 RECEPTOR ANTAGONIST; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG; (+ ) HUPRINE Z; (+-)-HUPRINE Z; AMINOQUINOLINE DERIVATIVE; CHOLINERGIC RECEPTOR BLOCKING AGENT; FUSED HETEROCYCLIC RINGS; MUSCARINIC RECEPTOR; PIRENZEPINE; TRITIUM;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BIOACCUMULATION; CHOLINERGIC ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG DETERMINATION; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; STIMULATION; ANIMAL; BINDING COMPETITION; BRAIN CORTEX; COMPARATIVE STUDY; CYTOLOGY; DOSE RESPONSE; DRUG INTERACTION; IN VITRO STUDY; SPRAGUE DAWLEY RAT;

AMINOQUINOLINES; ANIMALS; BINDING, COMPETITIVE; CEREBRAL CORTEX; CHOLINERGIC ANTAGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HIPPOCAMPUS; MALE; PIRENZEPINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, MUSCARINIC; TRITIUM;

EID: 17044404593     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.12.044     Document Type: Article

References (27)

1. M. Alcalá, N.M. Vivas, S. Hospital, P. Camps, D. Muñoz-Torrero, and A. Badia Characterisation of the anticholinesterase activity of two new tacrine-huperzine A hybrids Neuropharmacology 44 2003 749 755
2. G. Benzi, and A. Moretti Is there a rationale for the use of acetylcholinesterase inhibitors in the therapy of Alzheimer's disease? Eur. J. Pharmacol. 346 1998 1 13
3. E. Brown, D.A. Kendall, and S.R. Nahorski Inositol phospholipid hydrolysis in rat cerebral cortical slices: I. Receptor characterisation J. Neurochem. 42 1984 1379 1387
4. P. Camps, R. El Achab, J. Morral, D. Muñoz-Torrero, A. Badia, J. Baños, N.M. Vivas, X. Barril, M. Orozco, and F.J. Luque New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease J. Med. Chem. 43 2000 4657 4666
5. P. Camps, and D. Muñoz-Torrero Cholinergic drugs in pharmacotherapy of Alzheimer's disease Mini Rev. Med. Chem. 2 2002 11 25
6. S.T. Dekosky, R.E. Harbaugh, F.A. Schmitt, R.A. Bakay, H.C. Chui, D.S. Knopman, T.M. Reeder, A.G. Shetter, H.J. Senter, W. Markesbery The Intraventricular Bethanecol Study Group Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological and cognitive correlations Ann. Neurol. 32 1992 625 632
7. B. Drukarch, J.E. Leysen, and J.C. Stoof Further analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's disease Life Sci. 42 1988 1011 1017
8. 1 agonist xanomeline increases soluble amyloid precursor protein release from Chinese hamster ovary-m1 cells Life Sci. 57 1995 1183 1190
9. D.D. Flynn, and D.C. Mash Multiple in vitro interactions with and differential in vivo regulation of muscarinic receptor subtypes by tetrahydroaminoacridine J. Pharmacol. Exp. Ther. 250 1989 573 581
10. E. Giacobini Cholinergic receptors in human brain: effects of aging and Alzheimer's disease J. Neurosci. Res. 27 1990 548 560
11. J.P. Kiss, E.S. Vizi, and B.H.C. Westerink Effect of neostigmine on the hippocampal noradrenaline release: role of cholinergic receptors Neuroreport 10 1999 81 86
12. 1 agonists in the treatment of Alzheimer's disease Exp. Opin. Invest. Drugs 9 2000 2259 2267
13. 1 muscarinic receptor-G protein coupling in Alzheimer's disease J. Neuropathol. Exp. Neurol. 54 1995 783 789
14. A.I. Levey Immunological localization of m1-m5 muscarinic acetylcholine receptors in peripheral tissues and brain Life Sci. 52 1993 441 448
15. A. Maelicke, and E.X. Albuquerque Allosteric modulation of nicotinic acetylcholine receptors as a treatment strategy for Alzheimer's disease Eur. J. Pharmacol. 393 2000 165 170
16. 3H]acetylcholine release from rat cortical synaptosomes J. Neurosci. 5 1985 1202 1207
17. J. Musilkova, and S. Tucek The binding of cholinesterase inhibitors tacrine (tetrahydroaminoacridine) and 7-methoxytacrine to muscarinic acetylcholine receptors in rat brain in the presence of eserine Neurosci. Lett. 125 1991 113 116
18. L. Nilsson, A. Adem, J. Hardy, B. Winblad, and A. Nordberg Do tetrahydroaminoacridine (THA) and physostigmine restore acetylcholine release in Alzheimer brain via nicotinic receptors? J. Neural. Transm. 70 1987 357 368
19. 1 muscarinic receptors to G protein in Alzheimer disease Alzheimer Dis. Assoc. Disord. 5 1991 163 172
20. E.K. Perry, C.J. Smith, J.A. Court, J.R. Bonham, M. Rodway, and J.R. Atack Interaction of 9-amino-1,2,3,4-tetrahydroaminoacridine (THA) with human cortical nicotinic and muscarinic receptor binding in vitro Neurosci. Lett. 91 1988 211 216
21. T.N. Robinson, R.J. De Souza, A.J. Cross, and A.R. Green The mechanism of tetrahydroaminoacridine-evoked release of endogenous 5-hydroxytryptamine and dopamine from rat tissue prisms Br. J. Pharmacol. 98 1989 1127 1136
22. S. Roman, A. Badia, P. Camps, and M.V. Clos Potentiation effects of (±)-huprine X, a new acetylcholinesterase inhibitor, on nicotinic receptors in rat cortical synaptosomes Neuropharmacology 46 2004 95 102
23. H. Sershen, E. Toth, A. Lajtha, and E.S. Vizi Nicotine effects on presynaptic receptor interactions Ann. N.Y. Acad. Sci. 757 1995 238 244
24. A.L. Svensson, and A. Nordberg Tacrine interacts with an allosteric activator site on α4β2 nAChRs in M10 cells Neuroreport 7 1996 2201 2205
25. X.C. Tang, P. De Sarno, K. Sugaya, and E. Giacobini Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat J. Neurosci. Res. 24 1989 276 285
26. N.M. Vivas, F. Màrmol, J. Sallés, A. Badia, and M. Dierssen Action on noradrenergic transmission of an anticholinesterase: 9-amino-1,2,3,4-tetrahydroacridine Neuropharmacology 34 1995 367 375
27. S. Wonnacott Presynaptic nicotinic ACh receptors Trends Neurosci. 20 1997 92 98