Smoking promotes pathogenesis of aortic aneurysm through the 5-lipoxygenase pathway

Medical Hypotheses

Volumn 64, Issue 6, 2005, Pages 1117-1119

  Takagi, Hisato ^a   Umemoto, Takuya ^a  

^a SHIZUOKA MEDICAL CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CHEMOKINE; LEUKOTRIENE; LIPID; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; NICOTINE;

AORTA ANEURYSM; ATHEROSCLEROSIS; BIOSYNTHESIS; BONE MARROW CELL; CATALYSIS; CATALYST; COLON CARCINOGENESIS; DRUG POTENCY; ENDOTHELIUM CELL; HUMAN; INFLAMMATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY; SMOKING HABIT;

EID: 17044400917     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.11.045     Document Type: Article

References (15)

1. T.B. Wilmink, C.R. Quick, and N.E. Day The association between cigarette smoking and abdominal aortic aneurysms J Vasc Surg 30 1999 1099 1105
2. E.C. Hammond, and L. Garfinkel Coronary heart disease, stroke, and aortic aneurysm Arch Environ Health 19 1969 167 182
3. R. Doll, and R. Peto Mortality in relation to smoking: 20 years' observations on male British doctors Br Med J 2 1976 1525 1536
4. E.A. Murphy, D. Danna-Lopes, I. Sarfati, S.K. Rao, and J.R. Cohen Nicotine-stimulated elastase activity release by neutrophils in patients with abdominal aortic aneurysms Ann Vasc Surg 12 1998 41 45
5. B. Samuelsson Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation Science 220 1983 568 575
6. C.D. Funk Prostaglandins and leukotrienes: advances in eicosanoid biology Science 294 2001 1871 1875
7. Y.N. Ye, E.S. Liu, V.Y. Shin, W.K. Wu, J.C. Luo, and C.H. Cho Nicotine promoted colon cancer growth via epidermal growth factor receptor, c-Src, and 5-lipoxygenase-mediated signal pathway J Pharmacol Exp Ther 308 2004 66 72
8. Y.N. Ye, E.S. Liu, V.Y. Shin, W.K. Wu, and C.H. Cho The modulating role of nuclear factor-κB in the action of α7-nicotinic acetylcholine receptor and cross-talk between 5-lipoxygenase and cyclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone J Pharmacol Exp Ther 311 2004 123 130
9. Y.N. Ye, E.S. Liu, V.Y. Shin, W.K. Wu, and C.H. Cho Contributory role of 5-lipoxygenase and its association with angiogenesis in the promotion of inflammation-associated colonic tumorigenesis by cigarette smoking Toxicology 203 2004 179 188
10. H.A. Lehr, E. Kress, and M.D. Menger Involvement of 5-lipoxygenase products in cigarette smoke-induced leukocyte/endothelium interaction in hamsters Int J Microcirc Clin Exp 12 1993 61 73
11. R. De Caterina, A. Mazzone, and D. Giannessi Leukotriene B4 production in human atherosclerotic plaques Biomed Biochim Acta 47 1988 S182 S185
12. P. Patrignani, L. Daffonchio, A. Hernandez, R. De Caterina, G. Pelosi, and C. Patrono Release of contracting autacoids by aortae of normal and atherosclerotic rabbits J Cardiovasc Pharmacol 20 Suppl 12 1992 S208 S210
13. M. Mehrabian, H. Allayee, and J. Wong Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice Circ Res 91 2002 120 126
14. R. Spanbroek, R. Grabner, and K. Lotzer Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis Proc Natl Acad Sci USA 100 2003 1238 1243
15. L. Zhao, M.P. Moos, and R. Grabner The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm Nat Med 10 2004 966 973