Cognitive, emotional, physical and social effects of growth hormone treatment in adults with Prader-Willi syndrome

Journal of Intellectual Disability Research

Volumn 49, Issue 4, 2005, Pages 245-252

  Höybye, Charlotte ^a   Thoren M ^a   Bohm B ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adults; Behavioural; GH treatment; Intellectual; Physical status; Prader Willi

Indexed keywords

CITALOPRAM; ENALAPRIL; GROWTH HORMONE; HALOPERIDOL; HUMAN GROWTH HORMONE; INSULIN; LEVOMEPROMAZINE; LOOP DIURETIC AGENT; METFORMIN; METOPROLOL; PLACEBO;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; COHORT ANALYSIS; COMORBIDITY; COMPUTER PROGRAM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; EDEMA; EMOTION; FEMALE; FOLLOW UP; GENETIC DISORDER; GROWTH HORMONE DEFICIENCY; HEART FAILURE; HORMONE SUBSTITUTION; HUMAN; HYPERPHAGIA; HYPERTENSION; HYPOGONADISM; INTELLIGENCE QUOTIENT; MALE; MOTOR PERFORMANCE; MUSCLE HYPOTONIA; NEUROPSYCHOLOGICAL TEST; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHYSICAL PERFORMANCE; PILOT STUDY; PRADER WILLI SYNDROME; PSYCHOSOCIAL CARE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RANK SUM TEST; REACTION TIME; SELF EVALUATION; SHORT STATURE; SOCIAL STATUS; STATISTICAL ANALYSIS; TREATMENT OUTCOME;

ADULT; BODY COMPOSITION; BODY MASS INDEX; COGNITION DISORDERS; FEMALE; HUMAN GROWTH HORMONE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; PILOT PROJECTS; PRADER-WILLI SYNDROME; PSYCHOLOGY; PSYCHOMOTOR PERFORMANCE; PSYCHOTIC DISORDERS; QUALITY OF LIFE; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 17044400081     PISSN: 09642633     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2788.2005.00641.x     Document Type: Article

References (24)

1. Abstract R., Bengtsson B.-Å., Hernberg-Stahl E. et al. (1999) GH replacement in 1034 growth hormone deficient hypopituitary adults: demographic and clinical characteristics, dosing and safety. Clinical Endocrinology 50, 703-13.
2. Alpherts W. & Aldenkamp A. P. (1995) FePsy, The Iron Psyche Manual. Het Instituut voor Epilepsiebestrijding, Heemstede, The Netherlands.
3. Baum H. B., Katznelson L., Sherman J. C. et al. (1998) Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult onset GH deficiency. Journal of Clinical Endocrinology and Metabolism 83, 3184-9.
4. Borghgraef M., Fryns J. P. & Van Den Berghe H. (1990) Psychological profile and behavioural characteristics in 12 patients with Prader Willi syndrome. Genetic Counselling 1, 141-50.
5. Burman P., Ritzén E. M. & Lindgren A. C. (2001) Endocrine dysfunction in Prader-Willi syndrome. Endocrine Reviews 22, 787-99.
6. Caroll P. V., Christ E. R. & the members of Growth Hormone Research Society Scientific Committee (1998) Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Journal of Clinical Endocrinology and Metabolism 83, 382-95.
7. Cassidy S. B. & Morris C. A. (2002) Behavioral phenotypes in genetic syndromes: genetic clues to human behaviour. Advances in Paediatrics 49, 59-86.
8. Clarke D. J. (1993) Prader-Willi syndrome and psychoses. British Journal of Psychiatry 16, 680-4.
9. Deschemaeker M. J., Vogels A., Govers V., Borghgraef M., Willekens D., Swillen A., Verhoeven W. & Fryns J. P. (2002) Prader-Willi syndrome: new insights in the behavioural and psychiatric spectrum. Journal of Intellectual Disability and Research 46, 41-50.
10. Dykens E. M., Leckman J. F. & Cassidy S. B. (1996) Obsessions and compulsions in Prader-Willi syndrome. Journal of Child Psychology and Psychiatry 37, 995-1002.
11. Einfeld S. L., Smith A., Durvasula S., Florio T. & Tonge B. J. (1999) Behavior and emotional disturbance in Prader-Willi syndrome. American Journal of Medical Genetics 82, 123-7.
12. Florkowski C. M., Stevens I., Joyce P., Espiner E. A. & Donald R. A. (1998) Growth hormone replacement does not improve psychological well-being in adult hypopituitarism: a randomised crossover trial. Psychoneuroendocrinology 23, 57-63.
13. Harris D. (1963) Goodenough-Harris Drawing Test Manual. Harcourt Brace Jovanovich, Inc., New York.
14. Holm V. A., Cassidy S. B., Butler M. G., Hanchett J. M., Greenswag L. R., Whitman B. Y. & Greenberg F. (1993) Prader-Willi syndrome: consensus diagnostic criteria. Pediatrics 91, 398-401.
15. Höybye C., Hilding A. & Jacobsson H. (2003) Thorén growth hormone treatment improves body composition in adults with Prader-Willi syndrome. Clinical Endocrinology 58, 653-61.
16. Höybye C., Hilding A., Jacobsson H. & Thorén M. (2002) Metabolic profile and body composition in adults with Prader-Willi syndrome and severe obesity. Journal of Clinical Endocrinology and Metabolism 87, 3590-7.
17. Lezak M. D. (1995) Neuropsychological Assessment, 3rd edn. Oxford University Press, New York.
18. Lindgren A. C., Grandell U., Ritzén E. M. & Anvert M. (1996) Diagnosis of the Prader-Willi syndrome by proving the absence of unmethylated PW71 DNA fragment. Acta Paediatrica 85, 195-8.
19. Mård G., Lundin K., Borg G., Jonsson B. & Lindberg A. (1994) Growth hormone replacement therapy in adult hypopituitary patients with growth hormone deficiency: combined data from 12 European placebo-controlled clinical trails. Endocrinology and Metabolism 1 (Suppl. A), 43-9.
20. Murray R. D., Skillicorn C. J., Howell S. J. et al. (1999) Influences on quality of life in GH deficient adults and their effect on response to treatment. Clinical Endocrinology 51, 565-73.
21. Rydberg S. & Högheim R. (1974) Speedy Performance Test of Intelligence (IQ), Swedish version. Sven Rydberg and Skandinaviska Testförlaget AB, Stockholm, Sweden.
22. Sanmarti A., Lucas A., Hawkins F., Webb S. M. & Ulied A. (1999) Observational study in adult hypopituitary patients with untreated growth hormone deficiency (ODA study). Socio-economic impact and health status. Collaborative ODA (Observational GH Deficiency in Adults) Group. European Journal of Endocrinology 141, 481-9.
23. Wechsler D. (1999) Wechsler Intelligence Scale for Children, 3rd edn. Swedish version. Psykologiförlaget AB, Stockholm, Sweden.
24. Wirén L., Johansson G. & Bengtsson B. Å. (2001) A prospective investigation of quality of life and psychological well-being after the discontinuation of GH treatment in adolescent patients who had GH deficiency during childhood. Journal of Clinical Endocrinology and Metabolism 86, 3494-8.