Impact of patient age on propofol consumption during propofol-remifentanil anaesthesia

European Journal of Anaesthesiology

Volumn 22, Issue 2, 2005, Pages 123-128

  Kreuer, S ^a   Schreiber, J U ^a   Bruhn, J ^b   Wilhelm, Wolfram ^a,c,d  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c St Marien Hospital Lunen   (Germany)

^d St Marien Hospital   (Germany)

Author keywords

Age factors, outcome; Anaesthesia general, measurement, Narcotrend; Anaesthetics, intravenous, propofol; Opioids, remifentanil

Indexed keywords

PROPOFOL; REMIFENTANIL;

ADULT; AGE; AGED; ANESTHESIA INDUCTION; ANESTHESIA LEVEL; ANESTHETIC RECOVERY; ARTICLE; BODY WEIGHT; BOLUS INJECTION; CONTROLLED STUDY; DISEASE CLASSIFICATION; DOSE CALCULATION; DOSE TIME EFFECT RELATION; DRUG USE; ELECTRODE; ELECTROENCEPHALOGRAM; FEMALE; HUMAN; INDIVIDUAL BASED POPULATION MODEL; INFUSION; INTERINDIVIDUAL VARABILITY; INTRAVENOUS ANESTHESIA; LINEAR REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MINOR SURGERY; ORTHOPEDIC SURGERY; PATIENT MONITORING; STATISTICAL SIGNIFICANCE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; ANESTHESIA RECOVERY PERIOD; ANESTHESIA, INTRAVENOUS; ANESTHETICS, INTRAVENOUS; ELECTRIC STIMULATION; ELECTROENCEPHALOGRAPHY; ENDPOINT DETERMINATION; FEMALE; HUMANS; MALE; MIDDLE AGED; MONITORING, INTRAOPERATIVE; ORTHOPEDIC PROCEDURES; PIPERIDINES; PROPOFOL;

EID: 16844387334     PISSN: 02650215     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0265021505000232     Document Type: Article

References (20)

1. Stanski DR, Maitre PO. Population pharmacokinetics and pharmacodynamics of thiopental: the effect of age revisited. Anesthesiology 1990; 72: 412-422.
2. Arden J, Holley F, Stanski D. Increased sensitivity to etomidate in the elderly: initial distribution versus altered brain response. Anesthesiology 1986; 65: 19-27.
3. Minto CF, Schnider TW, Egan TD, et al. Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. Anesthesiology 1997; 86: 10-23.
4. Kirkpatrick T, Cockshott ID, Douglas EJ, Nimmo WS. Pharmacokinetics of propofol (diprivan) in elderly patients. Br J Anaesth 1988; 60: 146-150.
5. Dyck JB, Shafer SL. Effects of age on propofol pharmacokinetic. Semin Anesth 1992; 11: 2-4.
6. Schnider T, Minto C, Shafer S, et al. The influence of age on propofol pharmacodynamics. Anesthesiology 1999; 90: 1502-1516.
7. Kreuer S, Biedler A, Larsen R, Altmann S, Wilhelm W. Narcotrend monitoring allows faster emergence and a reduction of drug consumption in propofol-remifentanil anesthesia. Anesthesiology 2003; 99: 34-41.
8. Kreuer S, Biedler A, Larsen R, Schoth S, Altmann S, Wilhelm W. The Narcotrend - a new EEG monitor designed to measure the depth of anaesthesia. A comparison with bispectral index monitoring during propofol-remifentanil- anaesthesia. Anaesthesia 2001; 50: 921-925.
9. Schmidt GN, Bischoff P, Standl T, et al. Narcotrend, bispectral index, and classical electroencephalogram variables during emergence from propofol/remifentanil anesthesia. Anesth Analg 2000; 95: 1324-1330.
10. Wilhelm W, Kreuer S, Larsen R. Narcotrend EEG monitoring during total intravenous anaesthesia in 4,630 patients. Anaesthesist 2002; 51: 980-988.
11. Scheepstra GL, Booij LH, Rutten CL, Coenen LG. Propofol for induction and maintenance of anaesthesia: comparison between younger and older patients. Br J Anaesth 1989; 62: 54-60.
12. Doze VA, Shafer A, White PF. Propofol-nitrous oxide versus thiopental-isoflurane-nitrous oxide for general anesthesia. Anesthesiology 1988; 69: 63-71.
13. Schultz B, Kreuer S, Wilhelm W, Grouven U, Schultz A. Der Narcotrend®-Monitor Entwicklung und Interpretationsalgorithmus. Anaesthesist 2003; 52: 1143-1148 [in German].
14. Shafer SL. The pharmacology of anesthetic drugs in elderly patients. Anesthesiol Clin North America 2000; 18: 1-29.
15. Schüttler J, Ihmsen H. Population pharmacokinetics of propofol: a multicenter study. Anesthesiology 2000; 92: 727-738.
16. Wynne HA, Cope LH, Mutch E, Rawlins MD, Woodhouse KW, James OF. The effect of age upon liver volume and apparent liver blood flow in healthy man. Hepatology 1989; 9: 297-301.
17. Schnider T, Minto C, Gambus P, et al. The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology 1998; 88: 1170-1182.
18. Brody H. The aging brain. Acta Neurol Scand 1992; 137: 40-44.
19. Brody H. Structural changes in the aging nervous system. In: Blumenthal HT, ed. Interdisciplinary Topics in Gerontology. Basel: Karger, 1970:9-21.
20. Christian W. [The electroencephalogram in advanced age.] Nervenarzt 1984; 55: 517-524.