Differential effects of alcohol upon gluconeogenesis from lactate in young and old hepatocytes

Experimental Gerontology

Volumn 40, Issue 4, 2005, Pages 324-329

  Sumida, Ken D ^a   Crandall, Suzanne C ^a   Chadha, Puja L ^a   Qureshi, Tauseef ^a  

^a CHAPMAN UNIVERSITY   (United States)

Author keywords

Ethanol; Rats; U 14C glucose production; U 14C lactate

Indexed keywords

ALCOHOL; LACTIC ACID;

AGING; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GLUCONEOGENESIS; GLYCOGENOLYSIS; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 16844376499     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2005.01.005     Document Type: Article

References (21)

1. R.A. Arky, and N. Freinkel Hypoglycemic actions of alcohol V.M. Sardesai Biochemical and Clinical Aspects of Alcohol Metabolism 1969 Thomas Springfield, IL 67 80
2. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
3. R.S. Britton, L.A. Videla, G. Rachamin, F. Okuno, and Y. Israel Effect of age on metabolic tolerance and hepatomegaly following chronic ethanol administration Alcohol Clin. Exp. Res. 8 1984 528 534
4. K.E. Crow, N.W. Cornell, and R.L. Veech Lactate-stimulated ethanol oxidation in isolated rat hepatocytes Biochem. J. 172 1978 29 36
5. M. Dubois, K.A. Giles, J.K. Hamilton, P.A. Rebers, and F. Smith Colorimetric method for determination of sugars and related substances Anal. Chem. 28 1956 350 356
6. J.H. Exton, and C.R. Park Control of gluconeogenesis in liver. I. General features of gluconeogenesis in the perfused liver of rats J. Biol. Chem. 242 1967 2622 2636
7. G. Ferland, A. Perea, M. Audet, and T. Beatriz Characterization of liver lysosomal enzyme activity in hepatocytes, Kupffer and endothelial cells during aging: effect of dietary restriction Mech. Ageing Dev. 56 1990 143 154
8. H.J. Hohorst l-(+)-lactate determination with lactic dehydrogenase and DPN H.U. Bergmeyer Methods of Enzymatic Analysis 1963 Academic Press New York 266 270
9. Z. Kmiec, and A. Mysliwski Age-dependent changes of hormone-stimulated gluconeogenesis in isolated rat hepatocytes Exp. Gerontol. 18 1983 173 184
10. H.A. Krebs The effects of ethanol on the metabolic activities of the liver Adv. Enzyme Reg. 6 1968 467 480
11. H.A. Krebs, R.A. Freedland, R. Hems, and M. Stubbs Inhibition of hepatic gluconeogenesis by ethanol Biochem. J. 112 1969 117 124
12. M.R. Odio, and A. Brodish Effects of age on metabolic response to acute and chronic stress Am. J. Physiol. 254 1988 E617 E624
13. D.A. Podolin, M.J. Pasliassotti, T.T. Gleeson, and R.S. Mazzeo Influence of endurance training on the age-related decline in hepatic gluconeogenesis Mech. Ageing Dev. 75 1994 81 93
14. D.A. Podolin, T.T. Gleeson, and R.S. Mazzeo Hormonal regulation of hepatic gluconeogenesis: influence of age and training Am. J. Physiol. 270 1996 R365 R372
15. E. Raabo, and T.C. Terkildsen On the enzymatic determination of blood glucose Scan. J. Clin. Lab. Invest. 12 1960 402 407
16. V. Sastre, F.V. Pallardo, R. Pla, A. Pellin, G. Juan, J.E. O'Connor, J.M. Estrela, J. Miquel, and J. Vina Aging of the liver: age-associated mitochondrial damage in intact hepatocytes Hepatology 24 1996 1199 1205
17. R.D. Stith, and R.E. McCallum Effects of aging and endotoxin on hepatic glucocorticoid action and glucose metabolism in mice Mech. Ageing Dev. 30 1985 73 78
18. K.D. Sumida, J.H. Urdiales, and C.M. Donovan Enhanced gluconeogenesis from lactate in perfused livers after endurance training J. Appl. Physiol. 74 1993 782 787
19. K.D. Sumida, S.C. Crandall, P.L. Chadha, and T. Qureshi Hepatic gluconeogenic capacity from various precursors in young versus old rats Metabolism 51 2002 876 880
20. K.D. Sumida, T. Qureshi, M.J. Catanzaro, S.M. Arimoto, and F. Frisch Effect of age and endurance training on the capacity for epinephrine-stimulated gluconeogenesis in rat hepatocytes J. Appl. Physiol. 95 2003 712 719
21. H.E. Williams Alcoholic hypoglycemia and ketoacidosis Med. Clin. North Am. 68 1984 33 38