Effect of sharp debridement using curette on recalcitrant nonhealing venous leg ulcers: A concurrently controlled, prospective cohort study

Wound Repair and Regeneration

Volumn 13, Issue 2, 2005, Pages 131-137

  Williams, Dean ^a,b   Enoch, Stuart ^a   Miller, David ^a   Harris, Karen ^a   Price, Patricia ^a   Harding, Keith G ^a,b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISOLONE; STEROID;

AGED; AMBULATORY SURGERY; ARTICLE; CHRONIC DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CURETTE; DEBRIDEMENT; DRUG USE; EVALUATION; FEASIBILITY STUDY; FEMALE; HUMAN; INFECTION RATE; LEG ULCER; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; SAFETY; SURGICAL INSTRUMENT; WOUND HEALING; WOUND HEALING IMPAIRMENT; WOUND INFECTION;

AGED; AGED, 80 AND OVER; AMBULATORY SURGICAL PROCEDURES; CURETTAGE; DEBRIDEMENT; DISEASE PROGRESSION; FEASIBILITY STUDIES; FEMALE; HUMANS; MALE; PROSPECTIVE STUDIES; TREATMENT OUTCOME; VARICOSE ULCER; WOUND HEALING;

EID: 16844372361     PISSN: 10671927     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1067-1927.2005.130203.x     Document Type: Article

References (29)

1. Callam MJ, Ruckley CV, Harper DR, Dale JJ. Chronic ulceration of the leg: extent of the problem and provision of care. BMJ 1985;290:1855-6.
2. Nelzen O, Bergqvist D, Lindhagen A. The prevalence of chronic lower-limb ulceration has been underestimated: results of a validated population questionnaire. Br J Surg 1996;83:255-8.
3. Falanga V. Classifications for wound bed preparation and stimulation of chronic wounds. Wound Rep Reg 2000;8:347-52.
4. Edlich RF, Panek PH, Rodeheaver GT, Turnbull VG, Kurtz LD, Edgerton MT. Physical and chemical configuration of sutures in the development of surgical infection. Ann Surg 1973;177:679-88.
5. Schultz GS, Sibbald RG, Falanga V, Ayello EA, Dowsett C, Harding K, Romanelli M, Stacey MC, Teot L, Vanscheidt W. Wound bed preparation: a systematic approach to wound management. Wound Rep Reg 2003;11 (Suppl. 1):S1-S28.
6. Steed DL, Donohoe D, Webster MW, Lindsley L. Effect of extensive debridement and treatment on the healing of diabetic foot ulcers. Diabetic Ulcer Study Group. J Am Coll Surg 1996;183:61-4.
7. Drager E, Winter H. Surgical debridement versus enzymatic debridement. In: Baharestani M, Gottrup F, Holstein P, Vanscheidt W, editors. The clinical relevance of debridement. Berlin: Springer-Verlag, 1999:59-71.
8. Jones BF, Plassman P. An instrument to measure the dimensions of skin wounds. IEEE Transact Biomed Engineer 1995;42:464-70.
9. Mol MA, Nanninga PB, van Eendenburg JP, Westerhof W, Mekkes JR, van Ginkel CJ. Grafting of venous leg ulcers. An intra-individual comparison between cultured skin equivalents and full-thickness skin punch grafts. J Am Acad Dermatol 1991;24:77-82.
10. Lindgren C, Marcusson JA, Toftgard R. Treatment of venous leg ulcers with cryopreserved cultured allogenic keratinocytes: a prospective open controlled study. Br J Dermatol 1998;139:271-5.
11. Belcaro G, Cesarone MR, Nicolaides AN, Geroukkos G, Di Renzo A, Milani M, Ricci A, Brandolini R, Dugall M, Ruffini I, Cornelli U, Griffin M. Improvement of microcirculation and healing of venous hypertension and ulcers with Crystacide. Evaluation of free radicals, laser Doppler flux and PO2. A prospective-randomized-controlled study. Angiology 2003;54:325-30.
12. Coleridge Smith PD. From skin disorders to venous leg ulcers, pathophysiology and efficacy of Daflon 500 mg in ulcer healing. Angiology 2003;54 (Suppl. 1):S45-50.
13. Montisci R, Ruju C, Massoni G, Sanfilippo R, Brotzu G. Chronic venous ulcer treatment with fascial pedunculated graft. J Cardiovasc Surg (Torino) 2003;44:249-53.
14. Falanga V, Sabolinski M. A bilayered living skin construct (Apligraf) accelerates complete closure of hard-to-heal venous ulcers. Wound Rep Reg 1999;7:201-7.
15. Brem H, Balledux J, Sukkarieh T, Carson P, Falanga V. Healing of venous ulcers of long term duration with a bilayered living skin substitute: results from a general surgery and dermatology department. Dermatol Surg 2001;27:915-9.
16. Schmeller W, Gaber Y, Gehl HB. Shave therapy is a simple, effective treatment of persistent venous leg ulcers. J Am Acad Dermatol 1998;39 (2 Part 1):232-8.
17. Barone EJ, Yager DR, Pozez AL, Olutoye OO, Crossland MC, Diegelmann RF, Cohen IK. Interleukin-1 alpha and collagenase activity are elevated in chronic wounds. Plast Reconstr Surg 1998;102:1023-7.
18. Harris IR, Yee KC, Walters CE, Cunliffe WJ, Kearney JN, Wood EJ, Ingham E. Cytokine and protease levels in healing and non-healing chronic venous leg ulcers. Exper Dermatol 1995;4:342-9.
19. Trengove NJ, Stacey MC, MacAuley S, Bennett N, Gibson J, Burslem F, Murphy G, Schultz G. Analysis of the acute and chronic wound environments: the role of proteases and their inhibitors. Wound Rep Reg 1999;7:442-52.
20. Yager DR, Zhang LY, Liang HX, Diegelmann RF, Cohen IK. Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids. J Invest Dermatol 1996;107:743-8.
21. Falanga V. Wound bed preparation and the role of enzymes: a case for multiple actions of therapeutic agents. Wounds 2002;14:47-57.
22. Falabella AF, Carson P, Eaglstein WH, Falanga V. The safety and efficacy of a proteolytic ointment in the treatment of chronic ulcers of the lower extremity. J Am Acad Dermatol 1998;39:737-40.
23. Davey ME, O'Toole GA. Microbial biofilms: from ecology and molecular genetics. Microbiol Mol Biol Rev 2000;64:847-67.
24. Bradley M, Cullum N, Sheldon T. The debridement of chronic wounds: a systematic review. Health Technol Assess 1999;3 (17 Part 1):iii-iv, 1-78.
25. Lyons AS, Petrucelli RJ. In: Abrams HA, editor. Medicine: an illustrated history. New York: Aberdale Press, 1987:7-21.
26. Sieggreen MY, Makelbust J. Debridement choices and challenges. Adv Wound Care 1997;10:32-7.
27. Baharestani M. The clinical relevance of debridement. In: Baharestani M, Gottrup F, Holstein P, Vanscheidt W, editors. The clinical relevance of debridement. Berlin: Springer-Verlag, 1999:3.
28. Higgins KR, Ashry HR. Wound dressings and topical agents. Clin Podiatr Med Surg 1995;12:31-40.
29. Rosenthal D, Murphy F, Gottschalk R, Baxter M, Lycka B, Nevin K. Use of topical anaesthetic cream to reduce pain during sharp debridement of chronic leg ulcers. J Wound Care 2001;10:503-5.