Treatment of venous leg ulcers with cryopreserved cultured allogeneic keratinocytes: A prospective open controlled study

British Journal of Dermatology

Volumn 139, Issue 2, 1998, Pages 271-275

  Lindgren, C ^a   Marcusson, J A ^a   Toftgard R ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALLOGRAFT; ARTICLE; CELL TRANSPLANTATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CRYOPRESERVATION; FEMALE; HUMAN; KERATINOCYTE; LEG ULCER; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; WOUND DRESSING;

AGED; AGED, 80 AND OVER; BANDAGES; CELL CULTURE TECHNIQUES; CHRONIC DISEASE; CRYOPRESERVATION; FEMALE; HUMANS; KERATINOCYTES; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SKIN TRANSPLANTATION; VARICOSE ULCER; WOUND HEALING;

EID: 0031813771     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2133.1998.02364.x     Document Type: Article

References (16)

1. Nelzén O, Bergqvist D, Lindhagen A. The prevalence of chronic lower-limb ulceration has been underestimated: results of a validated population questionnaire. Br J Surg 1996; 83: 255-8.
2. Nelzén O, Bergqvist D, Lindhagen A. Leg ulcer etiology - a cross sectional population study. J Vasc Surg 1991; 14: 557-64.
3. Nelzén O. The leg ulcers known to health-care professionals are only the tip of the iceberg. Scope Phlebol Lymphol 1994; 1: 10-14.
4. Nelzén O, Bergqvist D. Chronic venous insufficiency and leg ulcers: How big is the problem? Perspective Vasc Surg 1994; 7: 33-42.
5. Nelzén O, Bergqvist D, Lindhagen A. Venous and non-venous leg ulcers: clinical history and appearance in a population study. Br J Surg 1994; 81: 182-7.
6. Meyberry JC, Moneta GL, Taylor LM, Porter JM. Fifteen-year results of ambulatory compression therapy for chronic venous ulcers. Surgery 1991; 109: 575-81.
7. Ruckley CV. Treatment of venous ulceration - compression therapy. Phlebology 1992; 7 (Suppl. 1): 22-6.
8. Nelzén O, Bergqvist D, Lindhagen A. Long-term prognosis for patients with chronic leg ulcers: a prospective cohort study. Eur J Vasoendovasc Surg 1997; 13: 500-8.
9. Ohlsson P, Larsson K, Lindholm C, Möller M. A cost-effectiveness study of leg ulcer treatment in primary care. Scand J Prim Health Care 1994; 12: 295-9.
10. Leigh IM, Purkis PE, Navsaria HA, Phillips TJ. Treatment of chronic venous ulcers with sheets of cultured allogeneic keratinocytes. Br J Dermatol 1987; 117: 591-7.
11. Leigh IM, Purkis PE. Culture grafted leg ulcers. Clin Exp Dermatol 1986; 11: 650-2.
12. Marcusson JA, Lindgren C, Berghard A, Toftgård R. Allogeneic cultured keratinocytes in the treatment of leg ulcers. Acta Derm Venereol (Stockh) 1992; 72: 61-4.
13. Berghard A, Gradin K, Toftgård R. Serum and extracellular calcium modulate induction of cytochrome P-450IAI in human keratinocytes. J Biol Chem 1990; 265: 21086-90.
14. Gilman TH. Parameter for measurement of wound closure. Wounds 1990; 2: 95-101.
15. Teepe RGC, Koebrugge EJ, Ponec M, Vermeer BJ. Fresh versus cryopreserved cultured allografts for the treatment of chronic skin ulcers. Br J Dermatol 1990; 122: 81-9.
16. Tatnall FM, Leigh IM, Gibson JR. Comparative study of antiseptic toxicity on basal keratinocytes, transformed human keratinocytes and fibroblasts. Skin Pharmacol 1990; 3: 157-63.