Novel routes for metabolism of 7-ketocholesterol

Rejuvenation Research

Volumn 8, Issue 1, 2005, Pages 9-12

  Jessup, Wendy ^a,b   Brown, Andrew J ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b PRINCE OF WALES HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 7 OXOCHOLESTEROL; 7BETA HYDROXYCHOLESTEROL; ENZYME INHIBITOR; STEROL 27 HYDROXYLASE;

ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; DIABETES MELLITUS; DRUG TARGETING; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INSULIN RESISTANCE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW;

ANIMALS; ARTERIOSCLEROSIS; CYTOCHROME P-450 CYP27A1; HUMANS; KETOCHOLESTEROLS; STEROID HYDROXYLASES;

EID: 16844367090     PISSN: 15491684     EISSN: None     Source Type: Journal    
DOI: 10.1089/rej.2005.8.9     Document Type: Review

References (15)

1. Bjorkhem I, Meaney S, Diczfalusy U. Oxysterols in human circulation: which role do they have? Curr Opin Lipidol 2002;13:247-253.
2. Brown AJ, Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999;142:1-28.
3. Lyons MA, Samman S, Gatto L, et al. Rapid hepatic metabolism of 7-ketocholesterol in vivo: implications for dietary oxysterols. J Lipid Res 1999;40:1846-1857.
4. Lyons MA, Maeda N, Brown AJ. Paradoxical enhancement of hepatic metabolism of 7-ketocholesterol in sterol 27-hydroxylase-deficient mice. Biochim Biophys Acta 2002;1581:119-126.
5. Gaus K, Kritharides L, Schmitz G, et al. Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. FASEB J 2004;18:574-576.
6. Brown AJ, Watts GF, Burnett JR, et al. Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture. J Biol Chem 2000;275:27627-27633.
7. Burnett JR, Moses EA, Croft KD, et al. Clinical and biochemical features, molecular diagnosis and long-term management of a case of cerebrotendinous xanthomatosis. Clin Chim Acta 2001;306:63-69.
8. Schweizer RA, Zurcher M, Balazs Z, et al. Rapid hepatic metabolism of 7-ketocholesterol by 11beta-hydroxysteroid dehydrogenase type 1: species-specific differences between the rat, human, and hamster enzyme. J Biol Chem 2004;279:18415-18424.
9. Hult M, Elleby B, Shafqat N, et al. Human and rodent type 1 11beta-hydroxysteroid dehydrogenases are 7beta-hydroxycholesterol dehydrogenases involved in oxysterol metabolism. Cell Mol Life Sci 2004;61:992-999.
10. Song W, Chen J, Dean WL, et al. Purification and characterization of hamster liver microsomal 7alpha-hydroxycholesterol dehydrogenase. Similarity to type I 11beta-hydroxysteroid dehydrogenase. J Biol Chem 1998;273:16223-16228.
11. Nobel S, Abrahmsen L, Oppermann U. Metabolic conversion as a pre-receptor control mechanism for lipophilic hormones. Eur J Biochem 2001;268:4113-4125.
12. Robinzon B, Michael KK, Ripp SL, et al. Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases? Arch Biochem Biophys 2003;412:251-258.
13. Cai TQ, Wong B, Mundt SS, et al. Induction of 11beta-hydroxysteroid dehydrogenase type 1 but not -2 in human aortic smooth muscle cells by inflammatory stimuli. J Steroid Biochem Mol Biol 2001;77:117-122.
14. Thieringer R, Le Grand CB, Carbin L, et al. 11 Beta-hydroxysteroid dehydrogenase type 1 is induced in human monocytes upon differentiation to macrophages. J Immunol 2001;167:30-35.
15. RefExA Reference Database for Gene Expression Analysis [On-line]. Available: www.lsbm.org/site_e/index.html.