Down-regulation of CD9 in human ovarian carcinoma cell might contribute to peritoneal dissemination: Morphologic alteration and reduced expression of β1 integrin subsets

Cancer Research

Volumn 65, Issue 7, 2005, Pages 2617-2625

  Furuya, Mitsuko ^a   Kato, Hiroaki ^b   Nishimura, Norihiro ^c   Ishiwata, Isamu ^d   Ikeda, Hitoshi ^b   Ito, Ryoko ^b   Yoshiki, Takashi ^b,c   Ishikura, Hiroshi ^a  

^a CHIBA UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c GeneticLab Co   (Japan)

^d Ishiwata Obstet and Gynecol Hosp   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; ALPHA5 INTEGRIN; ALPHA6 INTEGRIN; BETA1 INTEGRIN; CD9 ANTIGEN; COLLAGEN; FIBRONECTIN; LAMININ; MATRIGEL; MESSENGER RNA; SMALL INTERFERING RNA; VERY LATE ACTIVATION ANTIGEN 3;

ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL ADHESION; CONTROLLED STUDY; DOWN REGULATION; EXTRACELLULAR MATRIX; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MICROSCOPY; MOUSE; NONHUMAN; OVARY CARCINOMA; PERITONEUM METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PURIFICATION;

ADENOCARCINOMA; ANIMALS; ANTIGENS, CD; ANTIGENS, CD29; CELL LINE, TUMOR; COLLAGEN; CYTOSKELETON; DOWN-REGULATION; DRUG COMBINATIONS; FEMALE; FIBRONECTINS; HUMANS; LAMININ; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; OVARIAN NEOPLASMS; PERITONEAL NEOPLASMS; PROTEOGLYCANS; RNA, SMALL INTERFERING; TIGHT JUNCTIONS; TRANSFECTION;

EID: 16844366288     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3123     Document Type: Article

References (43)

1. Nakaguchi H, Fujimaki T, Matsuno A, et al. Postoperative residual tumor growth of meningioma can be predicted by MIB-1 immunohistochemistry. Cancer 1999;85:2249-54.
2. Kabashima A, Maehara Y, Kakeji Y, et al. Clinicopathological features and overexpression of matrix metalloproteinases in intramucosal gastric carcinoma with lymph node metastasis. Clin Cancer Res 2000;6:3581-4.
3. Rofstad EK, Halsor EF. Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts. Cancer Res 2000;60:4932-8.
4. Takano Y, Kato Y, vanDiest PJ, et al. Cyclin D2 overexpression and lack of p27 correlate positively and cyclin E inversely with a poor prognosis in gastric cancer cases. Am J Pathol 2000;156:585-94.
5. Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996;86:353-64.
6. Montgomery E, Abraham SC, Fisher C, et al. CD44 loss in gastric stromal tumors as a prognostic marker. Am J Surg Pathol 2004;28:168-77.
7. Bukholm IK, Nesland JM, Borresen Dale AL. Re-expression of E-cadherin, α-catenin and β-catenin, but not of γ-catenin, in metastatic tissue from breast cancer patients. J Pathol 2000;190:15-9.
8. Endo K, Ueda T, Ueyama J, et al. Immunoreactive E-cadherin, α-catenin, β-catenin, γ-catenin proteins in hepatocellular carcinoma. Hum Pathol 2000;31:558-65.
9. Schuppan D, Ocker M. Integrin-mediated control of cell growth. Hepatology 2003;38:289-91.
10. Malliri A, Collard JG. Role of Rho-family proteins in cell adhesion and cancer. Curr Opin Cell Biol 2003;15:583-9.
11. Stipp CS, Kolesnikova TV, Hemler ME. Functional domains in tetraspanin proteins. Trends Biochem Sci 2003;28:106-12.
12. Iwamoto R, Higashiyama S, Mitamura T, et al. Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity. EMBO J 1994;13:2322-30.
13. Imai T, Kakizaki M, Nishimura M, et al. Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82. J Immunol 1995;155:1229-39.
14. Matsumoto AK, Martin DR, Carter RH, et al. Functional dissection of the CD21/CD19/TAPA-1/Leu-13 complex of B lymphocytes. J Exp Med 1993;178:1407-17.
15. Berditchevski F. Complexes of tetraspanins with integrins: more than meets the eye. J Cell Sci 2001;114:4143-51.
16. Berditchevski F, Odintsova E. Characterization of integrin-tetraspanin adhesion complexes: role of tetraspanins in integrin signaling. J Cell Biol 1999;146:477-92.
17. Gutierrez-Lopez MD, Ovalle S, Yanez-Mo M, et al. A functionally relevant conformational epitope on the CD9 tetraspanin depends on the association with activated β1 integrin. J Biol Chem 2003;278:208-18.
18. Longo N, Yanez-Mo M, Mittelbrunn M, et al. Regulatory role of tetraspanin CD9 in tumor-endothelial cell interaction during transendothelial invasion of melanoma cells. Blood 2001;98:3717-26.
19. Penas PF, Garcia-Diez A, Sanchez-Madrid F, et al. Tetraspanins are localized at motility-related structures and involved in normal human keratinocyte wound healing migration. J Invest Dermatol 2000;114:1126-35.
20. Miyake M, Nakano K, Ieki Y, et al. Motility-related protein 1 (MRP-1/CD9) expression: inverse correlation with metastases in breast cancer. Cancer Res 1995;55:4127-31.
21. Hashida H, Takabayashi A, Tokuhara T, et al. Integrin α3 expression as a prognostic factor in colon cancer: association with MRP-1/CD9 and KAI1/CD82. Int J Cancer 2002;97:518-25.
22. Higashiyama M, Doi O, Kodama K, et al. Immunohistochemically detected expression of motility-related protein-1 (MRP-1/CD9) in lung adenocarcinoma and its relation to prognosis. Int J Cancer 1997;74:205-11.
23. Funakoshi T, Tachibana I, Hoshida Y, et al. Expression of tetraspanins in human lung cancer cells: frequent downregulation of CD9 and its contribution to cell motility in small cell lung cancer. Oncogene 2003;22:674-87.
24. Uchida S, Shimada Y, Watanabe G, et al. Motility-related protein 1 (MRP-1/CD9) and KAI1/CD82 expression inversely correlate with lymph node metastases in esophageal squamous cell carcinoma. Br J Cancer 1999;79:1168-73.
25. Houle CD, Ding XY, Foley JF, et al. Loss of expression and altered localization of KAI1 and CD9 protein are associated with epithelial ovarian cancer progression. Gynecol Oncol 2002;86:69-78.
26. Sugiura T, Berditchevski F. Function of α3β1-tetraspanin protein complexes in tumor cell invasion. Evidence for the role of the complexes in production of matrix metalloproteinase 2 (MMP-2). J Cell Biol 1999;146:1375-89.
27. Hori H, Yano S, Koufuji K, et al. CD9 expression in gastric cancer and its significance. J Surg Res 2004;117:208-15.
28. Kawashima M, Doh-ura K, Mekada E, et al. CD9 expression in solid non-neuroepithelial tumors and infiltrative astrocytic tumors. J Histochem Cytochem 2002;50:1195-203.
29. Ishiwata I, Ishiwata C, Soma M, et al. Characterization of newly established human ovarian carcinoma cell line. Gynecol Oncol 1987;26:340-54.
30. Kato H, Ishikura H, Kawarada Y, et al. Antiangiogenic treatment for peritoneal dissemination of pancreas adenocarcinoma: a study using TNP-470. Jpn J Cancer Res 2001;92:67-73.
31. Hemler ME. Specific tetraspanin functions. J Cell Biol 2001;155:1103-7.
32. Maecker HT, Todd SC, Levy S. The tetraspanin superfamily: molecular facilitators. FASEB J 1997;11:428-42.
33. Boucheix C, Rubinstein E. Tetraspanins. Cell Mol Life Sci 2001;58:1189-205.
34. Ikeyama S, Koyama M, Yamaoko M, et al. Suppression of cell motility and metastasis by transfection with human motility-related protein (MRP-1/CD9) DNA. J Exp Med 1993;177:1231-7.
35. Zhang XA, Kazarov AR, Yang X, et al. Function of the tetraspanin CD151-α6β1 integrin complex during cellular morphogenesis. Mol Biol Cell 2002;13:1-11.
36. Sordat I, Decraene C, Silvestre T, et al. Complementary DNA arrays identify CD63 tetraspanin and α3 integrin chain as differentially expressed in low and high metastatic human colon carcinoma cells. Lab Invest 2002;82:1715-24.
37. Jones PH, Bishop LA, Watt FM. Functional significance of CD9 association with β1 integrins in human epidermal keratinocytes. Cell Adhes Commun 1996;4:297-305.
38. Park KR, Inoue T, Ueda M, et al. CD9 is expressed on human endometrial epithelial cells in association with integrins α(6), α(3) and β(1). Mol Hum Reprod 2000;6:252-7.
39. Kikkawa Y, Sanzen N, Fujiwara H, et al. Integrin binding specificity of laminin-10/11: laminin-10/11 are recognized by α3β1 and α6β 4 integrins. J Cell Sci 2000;113:869-76.
40. Wang YD, De Vos J, Jourdan M, et al. Cooperation between heparin-binding EGF-like growth factor and interleukin-6 in promoting the growth of human myeloma cells. Oncogene 2002;21:2584-92.
41. Sauer G, Windisch J, Kurzeder C, et al. Progression of cervical carcinomas is associated with down-regulation of CD9 but strong local re-expression at sites of transendothelial invasion. Clin Cancer Res 2003;9:6426-31.
42. Yauch RL, Berditchevski F, Harler MB, et al. Highly stoichiometric, stable, and specific association of integrin α3β1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol Biol Cell 1998;9:2751-65.
43. Sawada S, Yoshimoto M, Odintsova E, et al. The tetraspanin CD151 functions as a negative regulator in the adhesion-dependent activation of Ras. J Biol Chem 2003;278:26323-6.