Testing procedures for doping agents and differentiation of the origins of hormones

Japanese Journal of Forensic Toxicology

Volumn 23, Issue 1, 2005, Pages 1-12

  Ueki, Makoto ^a   Sato, Mitsuhiko ^a  

^a LSI MEDIENCE CORPORATION   (Japan)

Author keywords

Doping; EPO; HBOC; hGH; Hormones; Testing system

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ALCOHOL; ANABOLIC AGENT; ANTIESTROGEN; AROMATASE INHIBITOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CANNABINOID; CHORIONIC GONADOTROPIN; DIASPIRIN CROSSLINKED HEMOGLOBIN; DIURETIC AGENT; ERYTHROPOIETIN; FUROSEMIDE; GLUCOCORTICOID; HEMOGLOBIN; HEMOGLOBIN DERIVATIVE; HORMONE; HUMAN GROWTH HORMONE; LUTEINIZING HORMONE; MODAFINIL; NARCOTIC AGENT; OXYGLOBIN; PEPTIDE HORMONE; POLYHEM; POLYMERIZED HEMOGLOBIN; POLYOXYETHYLENE; PROPRANOLOL; RECOMBINANT HEMOGLOBIN; SELECTIVE ESTROGEN RECEPTOR MODULATOR; SOMATOMEDIN C; STANOZOLOL; STEROID; TESTOSTERONE; UNINDEXED DRUG;

ANALYTIC METHOD; ATHLETE; CROSS LINKING; DOPING; DRUG URINE LEVEL; ELECTROSPRAY MASS SPECTROMETRY; GAS CHROMATOGRAPHY; HORMONE STRUCTURE; HUMAN; ISOELECTRIC FOCUSING; LABORATORY TEST; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEOMICS; REVIEW; SPORT; TIME OF FLIGHT MASS SPECTROMETRY;

EID: 16844363749     PISSN: 09159606     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (26)

1. Catlin DH, Sekera MH, Ahrens BD et al.: Tetrahydrogestrinone: discovery, synthesis, and detection in urine. Rapid Commun Mass Spectrom, 18, 1245-1249 (2004).
2. Death AK, McGrath KC, Kazlauskas et al.: Tetrahydrogestrinone is a potent androgen and progestin. J Clin Endocrinol Metab, 89, 2498-2500 (2004).
3. World Anti Doping Agency: The 2005 Prohibited List International Standard. Downloadable WADA Official WEB Page, URL: http://www.wada-ama.org/en/ t3.asp?p=41627&pp=41626, 2004.
4. Martineau L, Horan MA, Rothwell NJ et al.: Salbutamol, a beta 2-adrenoceptor agonist, increases skeletal muscle strength in young men. Clin Sci, 83, 615-621 (1992).
5. World Anti Doping Agency: 2003 Laboratory Statistics. Downloadable WADA Official WEB Page, URL: http://www.wada-ama.org/en/t3.asp?p=41275&x=1&a= 111978, 2003.
6. WADA: International Standard for Laboratories (version 4.0). Downloadable WADA Official WEB Page, URL: http://www.wada-ama.org/en/t3.asp?p=41629&pp= 41626, 2004, pp57.
7. WADA: Independent Observer Report Olympic Summer Games 2004 Athens. Downloadable WADA Official WEB Page, URL: http://www.wada-ama.org/docs/web/ communications/publications/reports/athensioreport.pdf, 2004, pp57.
8. Horning S and Schänzer W: Steroid Screening using GC/ HRMS. In Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U (eds), Recent Advances in Doping Analysis-4, Verlag Sport und Buch Strauß, Köln, 1997, pp. 261-270.
9. US Federal Law: Dietary Supplement Health and Education Act of 1994, Federal Register/ US FDA, 1994.
10. Schänzer W: Analysis of Non-Hormonal Nutritional Supplements for Anabolic Androgenic Steroids - An International Study -. IOC Medical Commission (ed), International Olympic Committee WEB Page URL: http://multimedia.olympic. org/pdf/en report 324.pdf 2001, pp. 1-2.
11. Aguilera R, Chapman TE, Starcevic B et al.: Performance characteristics of a carbon isotope ratio method for detecting doping with testosterone based on urine diols: controls and athletes with elevated testosterone/epitestosterone ratios. Clin Chem, 47, 292-300 (2001).
12. Shackleton CH, Roitman E, Phillips A et al.: Confirming testosterone administration by isotope ratio mass spectrometric analysis of urinary androstanediols. Steroids, 62, 379-87 (1997).
13. Ueki M, Okano M: Analysis of exogenous dehydroepiandrosterone in urine by gas chromatography/ combustion/ isotope ratio mass spectrometry. Rapid Commun Mass Spectrom, 13, 2237-2243 (1999).
14. Ueki M, Takao Y, Okano M et al.: Differentiation of endogenous and exogenous steroids in urine by means of isotope ratio mass spectrometry. In Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U (eds), Recent Advances in Doping Analysis-9, Verlag Sport und Buch Strauß, Köln, 2002, pp. 145-154.
15. Okano M, Sato M, Ueki M: Five years follow-up study on steroid profiles in individuals. In Schänzer W, Geyer H, Gotzmann A, Mareck-Engelke U (eds), Recent Advances in Doping Analysis, Verlag Sport und Buch Strauß, Köln, 2004, in press.
16. Cole LA: Immunoassay of human chorionic gonadotropin, its free subunits, and metabolites. Clin Chem, 43, 2233-2243 (1997).
17. Lasne F: Double-blotting: a solution to the problem of non-specific binding of secondary antibodies in immunoblotting procedures. J Immunol Methods, 253, 125-131 (2001).
18. Hashimoto Y, Ikeda I, Ikeda M et al.: Construction of a specific and sensitive sandwich enzyme immunoassay for 20 kDa human growth hormone. J Immunol Methods, 221, 77-85 (1998).