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Volumn 22, Issue 24, 2004, Pages 5022-5025

Cardiotoxicity and neurotoxicity of high-dose continuous fluorouracil as a result of degradation compounds in the drug vials

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ANTINEOPLASTIC ANTIMETABOLITE; DRUG DERIVATIVE; EXCIPIENT; FLUOROACETALDEHYDE; FLUOROMALONIC ACID SEMIALDEHYDE; FLUOROURACIL; MALONIC ACID DERIVATIVE; TROMETAMOL;

EID: 16644396901     PISSN: 0732183X     EISSN: 15277755     Source Type: Journal    
DOI: 10.1200/JCO.2004.04.272     Document Type: Letter
Times cited : (11)

References (11)
  • 1
    • 0032950467 scopus 로고    scopus 로고
    • Cardiotoxicity of the antiproliferative compound fluorouracil
    • Becker K, Erckenbrecht JF, Haussinger D, et al: Cardiotoxicity of the antiproliferative compound fluorouracil. Drugs 57: 475-484, 1999
    • (1999) Drugs , vol.57 , pp. 475-484
    • Becker, K.1    Erckenbrecht, J.F.2    Haussinger, D.3
  • 3
    • 0033503867 scopus 로고    scopus 로고
    • Severe cardiotoxicity during 5-fluorouracil chemotherapy: A case and literature report
    • Kuropkat C, Griem K, Clark J, et al: Severe cardiotoxicity during 5-fluorouracil chemotherapy: A case and literature report. Am J Clin Oncol 22: 466-470, 1999
    • (1999) Am J Clin Oncol , vol.22 , pp. 466-470
    • Kuropkat, C.1    Griem, K.2    Clark, J.3
  • 4
    • 0031025605 scopus 로고    scopus 로고
    • High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy
    • Yeh KH, Cheng AL: High-dose 5-fluorouracil infusional therapy is associated with hyperammonaemia, lactic acidosis and encephalopathy. Br J Cancer 75: 464-465, 1997
    • (1997) Br J Cancer , vol.75 , pp. 464-465
    • Yeh, K.H.1    Cheng, A.L.2
  • 5
    • 0014834207 scopus 로고
    • Biochemical basis for fluorouracil neurotoxicity: The role of Krebs cycle inhibition by fluoroacetate
    • Koenig H, Patel A: Biochemical basis for fluorouracil neurotoxicity: The role of Krebs cycle inhibition by fluoroacetate. Arch Neurol 23: 155-160, 1970
    • (1970) Arch Neurol , vol.23 , pp. 155-160
    • Koenig, H.1    Patel, A.2
  • 6
    • 0019298802 scopus 로고
    • Cardiotoxic effects of 5-fluorouracil in the Guinea pig
    • Matsubara I, Kamiya J, Imai S: Cardiotoxic effects of 5-fluorouracil in the Guinea pig. Jpn J Pharmacol 30: 871-879, 1980
    • (1980) Jpn J Pharmacol , vol.30 , pp. 871-879
    • Matsubara, I.1    Kamiya, J.2    Imai, S.3
  • 7
    • 0026092322 scopus 로고
    • Fluoroacetaldehyde as cardiotoxic impurity in fluorouracil (Roche)
    • Lemaire L, Malet-Martino MC, Longo S, et al: Fluoroacetaldehyde as cardiotoxic impurity in fluorouracil (Roche). Lancet 337: 560, 1991
    • (1991) Lancet , vol.337 , pp. 560
    • Lemaire, L.1    Malet-Martino, M.C.2    Longo, S.3
  • 8
    • 0026665811 scopus 로고
    • Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug
    • Lemaire L, Malet-Martino MC, de Forni M, et al: Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug. Br J Cancer 66: 119-127, 1992
    • (1992) Br J Cancer , vol.66 , pp. 119-127
    • Lemaire, L.1    Malet-Martino, M.C.2    De Forni, M.3
  • 9
    • 6844251612 scopus 로고    scopus 로고
    • The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate
    • Arellano M, Malet-Martino M, Martino R, et al: The anti-cancer drug 5-fluorouracil is metabolized by the isolated perfused rat liver and in rats into highly toxic fluoroacetate. Br J Cancer 77: 79-88, 1998
    • (1998) Br J Cancer , vol.77 , pp. 79-88
    • Arellano, M.1    Malet-Martino, M.2    Martino, R.3
  • 10
    • 0028105304 scopus 로고
    • The Tris formulation of fluorouracil is more cardiotoxic than the sodium salt formulations
    • Lemaire L, Malet-Martino MC, Martino R, et al: The Tris formulation of fluorouracil is more cardiotoxic than the sodium salt formulations. Oncol Rep 1: 173-174, 1994
    • (1994) Oncol Rep , vol.1 , pp. 173-174
    • Lemaire, L.1    Malet-Martino, M.C.2    Martino, R.3
  • 11
    • 0033647041 scopus 로고    scopus 로고
    • Stability of commercial solutions of 5-fluorouracil for continuous infusion in an ambulatory pump
    • Fournet A, Gilard V, Malet-Martino M, et al: Stability of commercial solutions of 5-fluorouracil for continuous infusion in an ambulatory pump. Cancer Chemother Pharmacol 46: 501-506, 2000
    • (2000) Cancer Chemother Pharmacol , vol.46 , pp. 501-506
    • Fournet, A.1    Gilard, V.2    Malet-Martino, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.