Distribution of substance-P nerve fibers in intact and ruptured human anterior cruciate ligament: A semi-quantitative immunohistochemical assessment

Knee Surgery, Sports Traumatology, Arthroscopy

Volumn 12, Issue 5, 2004, Pages 497-502

  Witoński, Dariusz ^a   Wągrowska Danilewicz, Małgorzata ^a  

^a UNIVERSITY OF LODZ   (Poland)

Author keywords

Anterior cruciate ligament; Human; Innervation; Knee joint; Substance P fibers

Indexed keywords

MONOCLONAL ANTIBODY; NEUROPEPTIDE; RECEPTOR; SUBSTANCE P; SUBSTANCE P MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ANTERIOR CRUCIATE LIGAMENT; ANTERIOR CRUCIATE LIGAMENT RUPTURE; ARTICLE; CLINICAL ARTICLE; FEMALE; HEALING; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; INNERVATION; KNEE OSTEOARTHRITIS; LIGAMENT RUPTURE; LIGAMENT SURGERY; MALE; NERVE ENDING; NERVE FIBER; NEUROGENIC INFLAMMATION; NOCICEPTIVE RECEPTOR; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; STATISTICAL SIGNIFICANCE; SURGICAL PATIENT; TIME; TOTAL KNEE REPLACEMENT; ADOLESCENT; INJURY; MIDDLE AGED; PATHOLOGY; PHYSIOLOGY; RUPTURE; WOUND HEALING;

ADOLESCENT; ADULT; AGED; ANTERIOR CRUCIATE LIGAMENT; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE FIBERS; NOCICEPTORS; RUPTURE; SUBSTANCE P; TIME FACTORS; WOUND HEALING;

EID: 16644394438     PISSN: 09422056     EISSN: 14337347     Source Type: Journal    
DOI: 10.1007/s00167-003-0453-9     Document Type: Article

References (29)

1. Ackermann PW, Ahmed M, Kreicbergs A (2002) Early nerve regeneration after Achilles tendon rupture - a prerequisite for healing? A study in the rat. J Orthop Res 20:849-856
2. Ackermann PW, Finn A, Ahmed M (1999) Sensory neuropeptidergic pattern in tendon, ligament and joint capsule. A study in the rat. Neuroreport 10:2055-2060
3. Arcand MA, Rhalmi S, Rivard CH (2000) Quantification of mechanoreceptors in the canine anterior cruciate ligament. Int Orthop 24:272-275
4. Biedert RM, Stauffer E, Friederich NF (1992) Occurrence of free nerve endings in the soft tissue of the knee joint. A histologic investigation. Am J Sports Med 20:430-433
5. Denti M, Monteleone M, Berardi A, Panni AS (1994) Anterior cruciate ligament mechanoreceptors. Histologic studies on lesions and reconstruction. Clin Orthop 308:29-32
6. Gronblad M, Korkala O, Konttinen YT, Kuokkanen H, Liesi P (1991) Immunoreactive neuropeptides in nerves in ligamentous tissue. An experimental neuroimmunohistochemical study. Clin Orthop 265:291-296
7. Halata Z, Haus J (1989) The ultrastructure of sensory nerve endings in human anterior cruciate ligament. Anat Embryol (Berl) 179:415-421
8. Hanesch U, Heppelmann B, Schmidt RF (1997) Quantification of cat's articular afferents containing calcitonin gene-related peptide or substance-P innervating normal and acutely inflamed knee joints. Neurosci Lett 233:105-108
9. Hannafin JA, Attia ET, Warren RF, Bhargava MM (1999) Characterization of chemotactic migration and growth kinetics of canine knee ligament fibroblasts. J Orthop Res 17:398-404
10. Heppelmann B, Messlinger K, Neiss WF, Schmidt RF (1990) Ultrastructural three-dimensional reconstruction of group III and group IV sensory nerve endings ("free nerve endings") in the knee joint capsule of the cat: evidence for multiple receptive sites. J Comp Neurol 292:103-116
11. Hirasawa Y, Okajima S, Ohta M (2000) Nerve distribution to the human knee joint: anatomical and immunohistochemical study. Int Orthop 24:1-4
12. Kennedy JC, Alexander IJ, Hayes KC (1982) Nerve supply of the human knee and its functional importance. Am J Sports Med 10:329-335
13. Kolasinski SL, Haines KA, Siegel EL, Cronstein BN, Abramson SB (1992) Neuropeptides and inflammation. A somatostatin analog as a selective antagonists of neutrophil activation by substance-P. Arthritis Rheum 35:369-375
14. Krauspe R, Schmidt M, Schaible H (1992) Sensory innervation of the anterior cruciate ligament. An electrophysiological study of the response properties of single identified mechanoreceptors in the cat. J Bone Joint Surg Am 74:390-397
15. Marshall KW, Theriault E, Homonko DA (1994) Distribution of substance-P and calcitonin-related peptide immunoreactivity in the normal feline knee. J Rheumatol 21:883-889
16. Marui T, Niyibizi C, Georgescu HJ, Cao M, Kavalkovich KW, Levine RE, Woo SL-Y (1997) Effect of growth factors on matrix synthesis by ligament fibroblasts. J Orthop Res 15:18-23
17. Murray MM, Martin SD, Martin TL, Spector M (2000) Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am 82:1387-1397
18. Pernow B (1983) Substance-P. Pharmacol Rev 35:85-141
19. Sanchis-Alfonso V, Rosello-Sastre E (2000) Immunochistochemical analysis for neural markers of the lateral retinaculum in patients with isolated symptomatic patellofemoral malalignment. A neuroanatomic basis for anterior knee pain in the active young patients. Am J Sports Med 28:725-731
20. Schutte MJ, Dabezies EJ, Zimny ML, Happel L (1987) Neural anatomy of the human anterior cruciate ligament. J Bone Joint Surg Am 69:243-247
21. Scott DT, Lam FY, Ferrell WR (1994) Acute joint inflammation - mechanisms and mediators. Gen Pharmacol 25:1285-1296
22. Sjolander P, Johansson H, Sojka P, Rehnholm A (1989) Sensory nerve endings in the cat cruciate ligaments: a morphological investigation. Neurosci Lett 102:33-38
23. Tamura R, Hanesch U, Schmidt RF, Kumazawa T, Mizumura K (1998) Examination of co-localization gene-related peptide- and substance-P-like immunoreactivity in the knee joint of the dog. Neurosci Lett 18:53-56
24. Wallengren J, Chen D, Sundler F (1999) Neuropeptide-containing C-fibers and wound healing in rat skin. Neither capsaicin nor peripheral neurotomy affect the rate of healing. Br J Dermatol 140:400-408
25. Walsh DA, Salmon M, Mapp I, Garrett N, Blake D, Polak J (1994) Microvascular substance-P binding to normal and inflamed rat and human synovium. J Pharmacol Exp Ther 267:951-960
26. Witkowski J, Yang L, Wood DJ, Sung KL (1997) Migration and healing of ligament cells under inflammatory conditions. J Orthop Res 15:269-277
27. Witónski D, Wa̧growska-Danilewicz M (1999) Distribution of substance-P nerve fibers in the knee joint in patients with anterior knee pain syndrome. A preliminary report. Knee Surg Sport Traumatol Arthrosc 7:177-183
28. Wojtys EM, Beaman DN, Glover RA, Janda D (1990) Innervation of the human knee joint by substance-P fibers. Arthroscopy 6:254-263
29. Zimny ML, Schutte M, Dabezies E (1986) Mechanoreceptors in the human anterior cruciate ligament. Anat Rec 214:204-209