Absence of heparan sulfate proteoglycans in Lewy bodies and Lewy neurites in Parkinson's disease brains

Journal of Alzheimer's Disease

Volumn 6, Issue 5, 2004, Pages 469-474

  Van Horssen, Jack ^a   De Vos, Rob A I ^b   Jansen Steur, Ernst N H ^c   David, Guido ^d   Wesseling, Pieter ^a   De Waal, Robert M W ^a   Verbeek, Marcel M ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Laboratorium Pathologie Oost Nederland   (Netherlands)

^c MEDISCH SPECTRUM TWENTE   (Netherlands)

^d DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

Glycosaminoglycan; Heparan sulfate proteoglycan; Lewy body; Lewy neurites; Parkinson's disease

Indexed keywords

GLYCOSAMINOGLYCAN; PROTEOHEPARAN SULFATE; ALPHA SYNUCLEIN; MONOCLONAL ANTIBODY; NERVE PROTEIN; SNCA PROTEIN, HUMAN; SYNUCLEIN;

AGED; ARTICLE; BRAIN LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEWY BODY; MACROMOLECULE; MALE; NEURITE; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; SENILE PLAQUE; BRAIN; CELL AGGREGATION; CINGULATE GYRUS; IMMUNOLOGY; METABOLISM; NEUROFIBRILLARY TANGLE; PHYSIOLOGY;

AGED; ALPHA-SYNUCLEIN; ANTIBODIES, MONOCLONAL; BRAIN; CELL AGGREGATION; FEMALE; GLYCOSAMINOGLYCANS; GYRUS CINGULI; HEPARAN SULFATE PROTEOGLYCANS; HUMANS; IMMUNOHISTOCHEMISTRY; LEWY BODIES; MALE; NERVE TISSUE PROTEINS; NEURITES; NEUROFIBRILLARY TANGLES; PARKINSON DISEASE; SYNUCLEINS;

EID: 16644393251     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2004-6502     Document Type: Article

References (31)

1. M. Baba, S. Nakajo, P.H. Tu, T. Tomita, K. Nakaya, V.M. Lee, J.Q. Trojanowski and T. Iwatsubo, Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies, Am. J. Pathol. 152 (1998), 879-884.
2. H. Braak, K. Del Tredici, U. Rub, R.A. De Vos, E.N. Jansen Steur and E. Braak, Staging of brain pathology related to sporadic Parkinson's disease, Neurobiol. Aging 24 (2003), 197-211.
3. G.M. Castillo, C. Ngo, J. Cummings, T.N. Wight and A.D. Snow, Perlecan binds to the beta-amyloid proteins (A beta) of Alzheimer's disease, accelerates A beta fibril formation, and maintains A beta fibril stability, J. Neurochem. 69 (1997), 2452-2465.
4. J.A. Cohlberg, J. Li, V.N. Uversky and A.L. Fink, Heparin and other glycosaminoglycans stimulate the formation of amyloid fibrils from alpha-synuclein in vitro, Biochemistry 41 (2002), 1502-1511.
5. S.L. Cotman, W. Halfter and G.J. Cole, Agrin binds to beta-amyloid (Abeta), accelerates abeta fibril formation, and is localized to Abeta deposits in Alzheimer's disease brain, Mol. Cell. Neurosci. 15 (2000), 183-198.
6. H. de-Boeck, V. Lories, G. David, J.J. Cassiman and H. Vanden-Berghe, Identification of a 64 kd heparan sulphate proteoglycan core protein from human lung fibroblast plasma membranes with a monoclonal antibody, Biochem. J. 247 (1987), 765-771.
7. J. Davis-Salinas, S.M. Saporito-Irwin, F.M. Donovan, D.D. Cunningham and W.E. Van Nostrand, Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid β-protein precursor, J. Biol. Chem. 269 (1994), 22623-22627.
8. K. Del Trecidi, U.8. Rub, R.A. De Vos, J.R. Bohl and H. Braak, Where does parkinson disease pathology begin in the brain? J Neuropathol Exp Neurol 61 (2002), 413-426.
9. D.A. DeWitt, P.L. Richey, D. Praprotnik, J. Silver and G. Perry, Chondroitin sulfate proteoglycans are a common component of neuronal inclusions and astrocytic reaction in neurodegenerative diseases, Brain Res 656 (1994), 205-209.
10. J.E. Duda, V.M. Lee and J.Q. Trojanowski, Neuropathology of synuclein aggregates, J. Neurosci. Res. 61 (2000), 121-127.
11. J.M. George, H. Jin, W.S. Woods and D.F. Clayton, Characterization of a novel protein regulated during the critical period for song learning in the zebra finch, Neuron 15 (1995), 361-372.
12. M. Goedert, Alpha-synuclein and neurodegenerative diseases, Nat. Rev. Neurosci. 2 (2001), 492-501.
13. M. Goedert and M.G. Spillantini, Lewy body diseases and multiple system atrophy as alpha-synucleinopathies, Mol. Psychiatry 3 (1998), 462-465.
14. M. Hasegawa, R.A. Crowther, R. Jakes and M. Goedert, Alzheimer-like changes in microtubule-associated protein Tau induced by sulfated glycosaminoglycans. Inhibition of microtubule binding, stimulation of phosphorylation, and filament assembly depend on the degree of sulfation, J. Biol. Chem. 272 (1997), 33118-33124.
15. F. Hernandez, M. Perez, J.J. Lucas and J. Avila, Sulfoglycosaminoglycan content affects PHF-tau solubility and allows the identification of different types of PHFs, Brain Res 935 (2002), 65-72.
16. E. Junn, R.D. Ronchetti, M.M. Quezado, S.Y. Kim and M.M. Mouradian, Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies, Proc. Natl. Acad. Sci. USA. 100 (2003), 2047-2052.
17. L. Maroteaux, J.T. Campanelli and R.H. Scheller, Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal, J. Neurosci. 8 (1988), 2804-2815.
18. D.D. Murphy, S.M. Rueter, J.Q. Trojanowski and V.M. Lee, Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons, J. Neurosci. 20 (2000), 3214-3220.
19. G. Perry, P. Richey, S.L. Siedlak, P. Galloway, M. Kawai and P. Cras, Basic fibroblast growth factor binds to filamentous inclusions of neurodegenerative diseases, Brain Res 579 (1992), 350-352.
20. G. Perry, S.L. Siedlak, P. Richey, M. Kawai, P. Cras, R.N. Kalaria, P.G. Galloway, J.M. Scardina, B. Cordell, B.D. Greenberg et al, Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease, J. Neurosci. 11 (1991), 3679-3683.
21. M.S. Pollanen, D.W. Dickson and C. Bergeron, Pathology and biology of the Lewy body, J. Neuropathol, Exp. Neurol. 52 (1993), 183-191.
22. A.D. Snow, R. Sekiguchi, D. Nochlin, P. Fraser, K. Kimata, A. Mizutani, M. Arai, W.A. Schreier and D.G. Morgan, An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar Abeta-amyloid in rat brain, Neuron 12 (1994), 219-234.
23. A.D. Snow and T.N. Wight, Proteoglycans in the pathogenesis of Alzheimer's disease and other amyloidoses, Neurobiol. Aging 10 (1989), 481-497.
24. V.N. Uversky, J. Li, K. Bower and A.L. Fink, Synergistic effects of pesticides and metals on the fibrillation of alpha-synuclein: implications for Parkinson's disease, Neurotoxicology 23 (2002), 527-536.
25. J. van-den-Born, L.P. Van-den-Heuvel, M.A. Bakker, J.H. Veerkamp, K.J. Assmann and J.H. Berden, Monoclonal antibodies against the protein core and glycosaminoglycan side chain of glomerular basement membrane heparan sulfate proteoglycan: characterization and immunohistological application in human tissues, J. Histochem. Cytochem. 42 (1994), 89-102.
26. J. van Horssen, J. Kleinnijenhuis, C.N. Maass, A.A. Rensink, I. Otte-Höller, G. David, L.P. van den Heuvel, P. Wesseling, R.M. de Waal and M.M. Verbeek, Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques, Neurobiol. Aging 23 (2002), 537-545.
27. J. van Horssen, I. Otte-Höller, G. David, M.L. Maat-Schieman, L.P. van den Heuvel, P. Wesseling, R.M. de Waal and M.M. Verbeek, Heparan sulfate proteoglycan expression in cerebrovascular amyloid beta deposits in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis (Dutch) brains, Acta Neuropathol. (Berl.) 102 (2001), 604-614.
28. J. van Horssen, M.M. Wilhelmus, R. Heljasvaara, T. Pihlajaniemi, P. Wesseling, R.M de Waal and M.M. Verbeek, Collagen XVIII: a novel heparan sulfate proteoglycan associated with vascular amyloid depositions and senile plaques in Alzheimer's disease brains, Brain Pathol 12 (2002), 456-462.
29. J. van Horssen, P. Wesseling, L.P. van den Heuvel, R.M. de Waal and M.M. Verbeek, Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders, Lancet Neurol 2 (2003), 482-492.
30. M.M. Verbeek, I. Otte-Höller, J. van den Born, L.P. van den Heuvel, G. David, P. Wesseling and de R.M. Waal, Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain, Am. J. Pathol. 155 (1999), 2115-2125.
31. R.A. de Vos, E.N. Jansen, F.C. Stam, R. Ravid and D.F. Swaab, Lewy body disease: clinico-pathological correlations in 18 consecutive cases of Parkinson's disease with and without dementia, Clin Neurol Neurosurg 97 (1995), 13-22.