Movement-related discharge in the cerebellar nuclei persists after local injections of GABAA antagonists

Journal of Neurophysiology

Volumn 93, Issue 1, 2005, Pages 35-43

  Holdefer, R N ^a   Houk, J C ^a   Miller, L E ^a,b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BICUCULLINE; PYRIDAZINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CEREBELLUM CORTEX; CEREBELLUM NUCLEUS; CLIMBING FIBER; EPILEPTIC DISCHARGE; EXCITATION; INJECTION; LIMB MOVEMENT; LOCUS CERULEUS; MACACA; MOSSY FIBER; MOTOR ACTIVITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; RAPHE NUCLEUS; SINGLE UNIT ACTIVITY; ACTION POTENTIAL; ANIMAL; ANIMAL BEHAVIOR; COMPARATIVE STUDY; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HAPLORHINI; MOVEMENT (PHYSIOLOGY); NERVE CELL; PHYSIOLOGY; REACTION TIME; TIME;

ACTION POTENTIALS; ANIMALS; BEHAVIOR, ANIMAL; BICUCULLINE; CEREBELLAR NUCLEI; HAPLORHINI; MOVEMENT; NEURONS; PYRIDAZINES; REACTION TIME; RECEPTORS, GABA-A; TIME FACTORS;

EID: 16644389758     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.00603.2004     Document Type: Article

References (41)

1. Aizenman CD and Linden DJ. Regulation of the rebound depolarization and spontaneous firing patterns of deep nuclear neurons in slices of rat cerebellum. J Neurophysiol 82: 1697-1709, 1999.
2. Allen GI, Gilbert PF, and Yin TC. Cerebral and peripheral inputs to interpositus neurons in monkey. Brain Res 105: 337-341, 1976.
3. Allen GI, Gilbert PF, and Yin TC. Convergence of cerebral inputs onto dentate neurons in monkey. Exp Brain Res 32: 151-170, 1978.
4. Allen GI and Tsukahara N. Cerebrocerebellar communication systems. Physiol Rev 54: 957-1006, 1974.
5. Anchisi D, Scelfo B, and Tempia F. Postsynaptic currents in deep cerebellar nuclei. J Neurophysiol 85: 323-331, 2001.
6. Brodal P and Bjaalie JG. Salient anatomic features of the cortico-pontocerebellar pathway. Prog Brain Res 114: 227-249, 1997.
7. Bruckmoser P, Hepp-Reymond MC, and Wiesendanger M. Cortical influence on single neurons of the lateral reticular nucleus of the cat. Exp Neurol 26: 239-252, 1970.
8. Czubayko U, Sultan F, Thier P, and Schwarz C. Two types of neurons in the rat cerebellar nuclei as distinguished by membrane potentials and intracellular fillings. J Neurophysiol 85: 2017-2029, 2001.
9. de Zeeuw CI, Holstege JC, Ruigrok TJ, and Voogd J. Ultrastructural study of the GABAergic, cerebellar, and mesodiencephalic innervation of the cat medial accessory olive: anterograde tracing combined with immunocytochemistry. J Comp Neurol 284: 12-35, 1989.
10. Dias EC and Segraves MA. A pressure system for the microinjection of substances into the brain of awake monkeys. J Neurosci Methods 72: 43-47, 1997.
11. Eccles JC, Ito M, and Szentagothai J. Cerebellum as a Neuronal Machine. New York: Springer-Verlag, 1967.
12. Fanselow EE, Sameshima K, Baccala LA, and Nicolelis MA. Thalamic bursting in rats during different awake behavioral states. Proc Natl Acad Sci USA 98: 15330-15335, 2001.
13. Flumerfelt BA, Otabe S, and Courville J. Distinct projections to the red nucleus from the dentate and interposed nuclei in the monkey. Brain Res 50: 408-414, 1973.
14. Fortier PA, Kalaska JF, and Smith AM. Cerebellar neuronal activity related to whole-arm reaching movements in the monkey. J Neurophysiol 62: 198-211, 1989.
15. Gauck V, Thomann M, Jaeger D, and Borst A. Spatial distribution of low-and high-voltage-activated calcium currents in neurons of the deep cerebellar nuclei. J Neurosci 21: 1-4, 2001.
16. Guido W and Weyand T. Burst responses in thalamic relay cells of the awake behaving cat. J Neurophysiol 74: 1782-1786, 1995.
17. Harvey RJ, Porter R, and Rawson JA. The natural discharges of Purkinje cells in paravermal regions of lobules V and VI of the monkey's cerebellum. J Physiol 271: 515-536, 1977.
18. Harvey RJ, Porter R, and Rawson JA. Discharges of intracerebellar nuclear cells in monkeys. J Physiol 297: 559-580, 1979.
19. Holdefer RN, Miller LE, Chen LL, and Houk JC. Functional connectivity between cerebellum and primary motor cortex in the awake monkey. J Neurophysiol 84: 585-590, 2000.
20. Holdefer RN, Norton TT, and Godwin DW. Effects of bicuculline on signal detectability in lateral geniculate nucleus relay cells. Brain Res 488: 341-347, 1989.
21. Hoover JE and Strick PL. The organization of cerebellar and basal ganglia outputs to primary motor cortex as revealed by retrograde transneuronal transport of herpes simplex virus type 1. J Neurosci 19: 1446-1463, 1999.
22. Houk JC, Keifer J, and Barto AG. Distributed motor commands in the limb premotor network. Trends Neurosci 16: 27-33, 1993.
23. Hua SE and Houk JC. Cerebellar guidance of premotor network development and sensorimotor learning. Learn Mem 4: 63-76, 1997.
24. Li Q, Clark S, Lewis DV, and Wilson WA. NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity. J Neurosci 22: 3070-3080, 2002.
25. Martin JH, Cooper SE, Hacking A, and Ghez C. Differential effects of deep cerebellar nuclei inactivation on reaching and adaptive control. J Neurophysiol 83: 1886-1899, 2000.
26. Martin JH and Chez C. Pharmacological inactivation in the analysis of the central control of movement. J Neurosci Methods 86: 145-159, 1999.
27. Mason CR, Miller LE, Baker JF, and Houk JC. Organization of reaching and grasping movements in the primate cerebellar nuclei as revealed by focal muscimol inactivations. J Neurophysiol 79: 537-554, 1998.
28. Matsunami K. Neuronal activity in nuclei pontis and reticularis tegmenti pontis related to forelimb movements of the monkey. Neurosci Res 5: 140-156, 1987.
29. Miller LE, Holdefer RN, and Houk JC. Early excitatory effects in cerebellar nuclei after M1 stimulation in the awake monkey. J Neurosci 22, 2002a.
30. Miller LE, Holdefer RN, and Houk JC. The role of the cerebellum in modulating voluntary limb movement commands. Arch Ital Biol 140: 175-183, 2002b.
31. Robinson FR, Houk JC, and Gibson AR. Limb specific connections of the cat magnocellular red nucleus. J Comp Neurol 257: 553-577, 1987.
32. Schroeder CE, Javitt DC, Steinschneider M, Mehta AD, Givre SJ, Vaughan HG Jr, and Arezzo JC. N-Methyl-D-aspartate enhancement of phasic responses in primate neocortex. Exp Brain Res 114: 271-278, 1997.
33. Shinoda Y, Izawa Y, Sugiuchi Y, and Futami T. Functional significance of excitatory projections from the precerebellar nuclei to interpositus and dentate nucleus neurons for mediating motor, premotor and parietal cortical inputs. Prog Brain Res 114: 193-207, 1997.
34. Shinoda Y, Sugiuchi Y, Futami T, and Izawa R. Axon collaterals of mossy fibers from the pontine nucleus in the cerebellar dentate nucleus. J Neurophysiol 67: 547-560, 1992.
35. Siggins GR, Oliver AP, Hoffer BJ, and Bloom FE. Cyclic adenosine monophosphate and norepinephrine: effects on transmembrane properties of cerebellar Purkinje cells. Science 171: 192-194, 1971.
36. Smith MR, Nelson AB, and Du Lac S. Regulation of firing response gain by calcium-dependent mechanisms in vestibular nucleus neurons. J Neurophysiol 87: 2031-2042, 2002.
37. Sugihara I, Wu H, and Shinoda Y. Morphology of single olivocerebellar axons labeled with biotinylated dextran amine in the rat. J Comp Neurol 414: 131-148, 1999.
38. Thach WT. Discharge of cerebellar neurons related to two maintained postures and two prompt movements. II. Purkinje cell output and input. J Neurophysiol 33: 537-547, 1970.
39. Tsukahara N, Bando T, Murakami F, and Oda Y. Properties of cerebello-precerebellar reverberating circuits. Brain Res 274: 249-259, 1983.
40. van Kan PLE, Gibson AR, and Houk JC. Movement-related inputs to intermediate cerebellum of the monkey. J Neurophysiol 69: 74-94, 1993.
41. Wu HS, Sugihara I, and Shinoda Y. Projection patterns of single mossy fibers originating from the lateral reticular nucleus in the rat cerebellar cortex and nuclei. J Comp Neurol 411: 97-118, 1999.