메뉴 건너뛰기




Volumn 19, Issue 8, 2004, Pages 1320-1328

Skeletal changes in transgenic male mice expressing human cytochrome P450 aromatase

Author keywords

Aromatase; BMD; Bone formation rate; Estradiol; Histomorphometry; Testosterone

Indexed keywords

AROMATASE; ESTRADIOL; TESTOSTERONE; CALCEIN; FLUORESCEIN DERIVATIVE;

EID: 16644381629     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/JBMR.040510     Document Type: Article
Times cited : (21)

References (40)
  • 2
    • 0019942628 scopus 로고
    • Changes in bone mineral density of the proximal femur and spine with aging: Difference between the postmenopausal and senile osteoporosis syndromes
    • Riggs BL, Wahner HW, Seeman E, Offord KP, Dunn WL, Mazess RB, Johnson KA, Melton LJ III 1982 Changes in bone mineral density of the proximal femur and spine with aging: Difference between the postmenopausal and senile osteoporosis syndromes. J Clin Invest 70:716-723.
    • (1982) J Clin Invest , vol.70 , pp. 716-723
    • Riggs, B.L.1    Wahner, H.W.2    Seeman, E.3    Offord, K.P.4    Dunn, W.L.5    Mazess, R.B.6    Johnson, K.A.7    Melton III, L.J.8
  • 3
    • 0027212734 scopus 로고
    • The association of age, race, and sex with the location of proximal femoral fractures in the elderly
    • Hinton RY, Smith GS 1993 The association of age, race, and sex with the location of proximal femoral fractures in the elderly. J Bone Joint Surg Am 75:752-759.
    • (1993) J Bone Joint Surg Am , vol.75 , pp. 752-759
    • Hinton, R.Y.1    Smith, G.S.2
  • 7
    • 0023229530 scopus 로고
    • Hip fracture and the use of estrogens in postmenopausal women. The Framingham Study
    • Kiel DP, Felson DT, Anderson JJ, Wilson PW, Moskowitz MA 1987 Hip fracture and the use of estrogens in postmenopausal women. The Framingham Study. N Engl J Med 317:1169-1174.
    • (1987) N Engl J Med , vol.317 , pp. 1169-1174
    • Kiel, D.P.1    Felson, D.T.2    Anderson, J.J.3    Wilson, P.W.4    Moskowitz, M.A.5
  • 9
    • 0032572929 scopus 로고    scopus 로고
    • Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency
    • Bilezikian JP, Morishima A, Bell J, Grumbach MM 1998 Increased bone mass as a result of estrogen therapy in a man with aromatase deficiency. N Engl J Med 339:599-603.
    • (1998) N Engl J Med , vol.339 , pp. 599-603
    • Bilezikian, J.P.1    Morishima, A.2    Bell, J.3    Grumbach, M.M.4
  • 10
    • 0024853552 scopus 로고
    • Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis
    • Means GD, Mahendroo MS, Corbin CJ, Mathis JM, Powell FE, Mendelson CR, Simpson ER 1989 Structural analysis of the gene encoding human aromatase cytochrome P-450, the enzyme responsible for estrogen biosynthesis. J Biol Chem 264:19386-19391.
    • (1989) J Biol Chem , vol.264 , pp. 19386-19391
    • Means, G.D.1    Mahendroo, M.S.2    Corbin, C.J.3    Mathis, J.M.4    Powell, F.E.5    Mendelson, C.R.6    Simpson, E.R.7
  • 11
    • 0016272566 scopus 로고
    • The involvement of human placental microsomal cytochrome P-450 in aromatization
    • Thompson EA Jr, Siiteri PK 1974 The involvement of human placental microsomal cytochrome P-450 in aromatization. J Biol Chem 249:5373-5378.
    • (1974) J Biol Chem , vol.249 , pp. 5373-5378
    • Thompson Jr., E.A.1    Siiteri, P.K.2
  • 12
    • 0022393956 scopus 로고
    • Preparation and characterization of polyclonal and monoclonal antibodies against human aromatase cytochrome P-450 (P-450AROM), and their use in its purification
    • Mendelson CR, Wright EE, Evans CT, Porter JC, Simpson ER 1985 Preparation and characterization of polyclonal and monoclonal antibodies against human aromatase cytochrome P-450 (P-450AROM), and their use in its purification. Arch Biochem Biophys 243:480-491.
    • (1985) Arch Biochem Biophys , vol.243 , pp. 480-491
    • Mendelson, C.R.1    Wright, E.E.2    Evans, C.T.3    Porter, J.C.4    Simpson, E.R.5
  • 13
    • 0018893170 scopus 로고
    • The conversion of androstenedione to estrone, estradiol and testosterone in breast tissue
    • Perel E, Wilkins D, Killinger DW 1980 The conversion of androstenedione to estrone, estradiol and testosterone in breast tissue. J Steroid Biochem Mol Biol 13:89-94.
    • (1980) J Steroid Biochem Mol Biol , vol.13 , pp. 89-94
    • Perel, E.1    Wilkins, D.2    Killinger, D.W.3
  • 15
    • 0020326596 scopus 로고
    • Significance of aromatase activity in human breast cancer
    • Miller WR, Hawkins RA, Forrest APM 1982 Significance of aromatase activity in human breast cancer. Cancer Res 42(Suppl):3365-3368.
    • (1982) Cancer Res , vol.42 , Issue.SUPPL. , pp. 3365-3368
    • Miller, W.R.1    Hawkins, R.A.2    Forrest, A.P.M.3
  • 18
    • 0030958817 scopus 로고    scopus 로고
    • Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats
    • Vanderschueren D, Herck EV, Nijs J, Ederveen AGH, Coster RD, Bouillon R 1997 Aromatase inhibition impairs skeletal modeling and decreases bone mineral density in growing male rats. Endocrinology 138:2301-2307.
    • (1997) Endocrinology , vol.138 , pp. 2301-2307
    • Vanderschueren, D.1    Herck, E.V.2    Nijs, J.3    Ederveen, A.G.H.4    Coster, R.D.5    Bouillon, R.6
  • 19
    • 0029791716 scopus 로고    scopus 로고
    • Aromatization of androgens is important for skeletal maintenance of aged male rats
    • Vanderschueren D, Herck EV, Coster RD, Bouillon R 1996 Aromatization of androgens is important for skeletal maintenance of aged male rats. Calcif Tissue Int 59:179-183.
    • (1996) Calcif Tissue Int , vol.59 , pp. 179-183
    • Vanderschueren, D.1    Herck, E.V.2    Coster, R.D.3    Bouillon, R.4
  • 20
    • 0032499704 scopus 로고    scopus 로고
    • Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp 19 gene
    • Fisher CR, Graves KH, Parlovv AF, Simpson ER 1998 Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp 19 gene. Proc Natl Acad Sci USA 95:6965-6970.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6965-6970
    • Fisher, C.R.1    Graves, K.H.2    Parlovv, A.F.3    Simpson, E.R.4
  • 25
    • 0036772574 scopus 로고    scopus 로고
    • Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin
    • Rulli SB, Kuorelahti A, Karaer O, Pelliniemi LJ, Poutanen M, Huhtaniemi I 2002 Reproductive disturbances, pituitary lactotrope adenomas, and mammary gland tumors in transgenic female mice producing high levels of human chorionic gonadotropin. Endocrinology 143:4084-4095.
    • (2002) Endocrinology , vol.143 , pp. 4084-4095
    • Rulli, S.B.1    Kuorelahti, A.2    Karaer, O.3    Pelliniemi, L.J.4    Poutanen, M.5    Huhtaniemi, I.6
  • 26
    • 0028146984 scopus 로고
    • The mechanical strength of bone in different rat models of experimental osteoporosis
    • Peng Z, Tuukkanen J, Zhang HX, Jämsä T, Väänänen HK 1994 The mechanical strength of bone in different rat models of experimental osteoporosis. Bone 15:523-532.
    • (1994) Bone , vol.15 , pp. 523-532
    • Peng, Z.1    Tuukkanen, J.2    Zhang, H.X.3    Jämsä, T.4    Väänä nen, H.K.5
  • 27
    • 0033034865 scopus 로고    scopus 로고
    • Alteration in the mechanical competence and structural properties in the femoral neck and vertebrae of ovariectomized rats
    • Peng ZQ, Tuukkanen J, Zhang HX, Väänänen HK 1999 Alteration in the mechanical competence and structural properties in the femoral neck and vertebrae of ovariectomized rats. J Bone Miner Res 14:616-623.
    • (1999) J Bone Miner Res , vol.14 , pp. 616-623
    • Peng, Z.Q.1    Tuukkanen, J.2    Zhang, H.X.3    Väänänen, H.K.4
  • 28
    • 0030739131 scopus 로고    scopus 로고
    • Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging
    • Labrie F, Belanger A, Cusan L, Gomez JL, Candas B 1997 Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab 82:2396-2402.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2396-2402
    • Labrie, F.1    Belanger, A.2    Cusan, L.3    Gomez, J.L.4    Candas, B.5
  • 30
    • 0016810946 scopus 로고
    • Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol
    • McLachlan JA, Newbold RR, Bullock B 1975 Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol. Science 190:991-992.
    • (1975) Science , vol.190 , pp. 991-992
    • McLachlan, J.A.1    Newbold, R.R.2    Bullock, B.3
  • 31
    • 0022387223 scopus 로고
    • Lesions of the rete testis in mice exposed prenatally to diethylstilbestrol
    • Newbold RR, Bullock BC, McLachlan JA 1985 Lesions of the rete testis in mice exposed prenatally to diethylstilbestrol. Cancer Res 45:5145-5150.
    • (1985) Cancer Res , vol.45 , pp. 5145-5150
    • Newbold, R.R.1    Bullock, B.C.2    McLachlan, J.A.3
  • 32
    • 0025838142 scopus 로고
    • Regional differences in the prostate of the neonatally estrogenized mouse
    • Pylkkänen L, Santti R, Newbold R, McLachlan JA 1991 Regional differences in the prostate of the neonatally estrogenized mouse. Prostate 18:117-129.
    • (1991) Prostate , vol.18 , pp. 117-129
    • Pylkkänen, L.1    Santti, R.2    Newbold, R.3    McLachlan, J.A.4
  • 33
    • 0032879139 scopus 로고    scopus 로고
    • The potential roles of estrogens in regulating Leydig cell development and function: A review
    • Abney TO 1999 The potential roles of estrogens in regulating Leydig cell development and function: A review. Steroids 64:610-617.
    • (1999) Steroids , vol.64 , pp. 610-617
    • Abney, T.O.1
  • 35
    • 0030960403 scopus 로고    scopus 로고
    • The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice
    • Kimble RB, Bain S, Pacifici R 1997 The functional block of TNF but not of IL-6 prevents bone loss in ovariectomized mice. J Bone Miner Res 12:935-941.
    • (1997) J Bone Miner Res , vol.12 , pp. 935-941
    • Kimble, R.B.1    Bain, S.2    Pacifici, R.3
  • 36
    • 0027406163 scopus 로고
    • High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse
    • Bain SD, Bailey MC, Celino DL, Lantry MM, Edwards MW 1993 High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse. J Bone Miner Res 8:435-442.
    • (1993) J Bone Miner Res , vol.8 , pp. 435-442
    • Bain, S.D.1    Bailey, M.C.2    Celino, D.L.3    Lantry, M.M.4    Edwards, M.W.5
  • 37
    • 0032899486 scopus 로고    scopus 로고
    • High-dose estrogen induces de Novo medullary bone formation in female mice
    • Samuels A, Perry MJ, Tobias JH 1999 High-dose estrogen induces De Novo medullary bone formation in female mice. J Bone Miner Res 14:178-186.
    • (1999) J Bone Miner Res , vol.14 , pp. 178-186
    • Samuels, A.1    Perry, M.J.2    Tobias, J.H.3
  • 38
    • 0026535080 scopus 로고
    • 17β-estradiol stimulation of endosteal bone formation in the ovariectomized mouse: An animal model for the evaluation of bone-targeted estrogens
    • Edwards MW, Bain SD, Bailey MC, Lantry MM, Howard GA 1992 17β-estradiol stimulation of endosteal bone formation in the ovariectomized mouse: An animal model for the evaluation of bone-targeted estrogens. Bone 13:29-34.
    • (1992) Bone , vol.13 , pp. 29-34
    • Edwards, M.W.1    Bain, S.D.2    Bailey, M.C.3    Lantry, M.M.4    Howard, G.A.5
  • 39
    • 0015125346 scopus 로고
    • Studies on the site and mechanism of action of the growth inhibiting effects
    • Herbai G 1971 Studies on the site and mechanism of action of the growth inhibiting effects. Acta Physiol Scand 83:77-90.
    • (1971) Acta Physiol Scand , vol.83 , pp. 77-90
    • Herbai, G.1
  • 40
    • 0002767351 scopus 로고    scopus 로고
    • Structure and development of the skeleton
    • Bilezikian JP, Raisz LG, Rodan GA (eds.) Academic Press, San Diego, CA, USA
    • Marks SC, Odgren PR 2002 Structure and development of the skeleton. In: Bilezikian JP, Raisz LG, Rodan GA (eds.) Principles of Bone Biology. Academic Press, San Diego, CA, USA, pp. 3-15.
    • (2002) Principles of Bone Biology , pp. 3-15
    • Marks, S.C.1    Odgren, P.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.