New aspects of hexobarbital metabolism: Stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases

Yakugaku Zasshi

Volumn 124, Issue 12, 2004, Pages 857-871

  Takenoshita, Reiko ^a,b   Toki, Satoshi ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b NONE   (Japan)

Author keywords

3 hydroxyhexobarbital dehydrogenase; Aldo keto reductase; Glutathione conjugation; Hexobarbital; Hydroxysteroid dehydrogenase; Stereoselective metabolism

Indexed keywords

1,5 DIMETHYLBARBITURIC ACID; 2 CYCLOHEXENONE; 3 HYDROXYHEXOBARBITAL; 3 HYDROXYHEXOBARBITAL DEHYDROGENASE; 3' OXOHEXOBARBITAL; ALCOHOL DERIVATIVE; ALDO KETO REDUCTASE; ALPHA 3' HYDROXYHEXOBARBITAL; AMINO ACID; BARBITURIC ACID DERIVATIVE; BETA 3' HYDROXYHEXOBARBITAL; CYTOCHROME P450; DRUG METABOLITE; GLUCURONIC ACID; GLUTATHIONE; HEXOBARBITAL; HYDROXYSTEROID; HYDROXYSTEROID DEHYDROGENASE; HYPNOTIC AGENT; MONOMER; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; OXIDOREDUCTASE; SHORT ACTING DRUG; UNCLASSIFIED DRUG; 3-HYDROXYHEXOBARBITAL DEHYDROGENASE; ALCOHOL DEHYDROGENASE; CARBONYL REDUCTASE (NADPH); HYPNOTIC SEDATIVE AGENT;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; BILE; CONTROLLED STUDY; DEHYDROGENATION; DOG; DRUG CONJUGATION; DRUG GLUCURONIDATION; DRUG METABOLISM; DRUG PURIFICATION; DRUG TRANSFORMATION; ENANTIOMER; ENZYME SPECIFICITY; GLUTATHIONE METABOLISM; GOAT; GUINEA PIG; HAMSTER; HUMAN; ISOMER; LIVER CYTOSOL; LIVER MICROSOME; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PROTEIN FAMILY; RABBIT; RAT; REVIEW; STEREOCHEMISTRY; THIN LAYER CHROMATOGRAPHY; URINARY EXCRETION; ANIMAL; CHEMISTRY; ENZYMOLOGY; LIVER; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SPECIES DIFFERENCE; STEREOISOMERISM;

ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; ANIMALS; CRICETINAE; GLUTATHIONE; GUINEA PIGS; HEXOBARBITAL; HUMANS; HYDROXYSTEROID DEHYDROGENASES; HYPNOTICS AND SEDATIVES; LIVER; MICE; MOLECULAR SEQUENCE DATA; RABBITS; RATS; SPECIES SPECIFICITY; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 16644378596     PISSN: 00316903     EISSN: None     Source Type: Journal    
DOI: 10.1248/yakushi.124.857     Document Type: Review

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