Co-localization of nestin and PDX-1 in small evaginations of the main pancreatic duct in adult rats

Journal of Molecular Histology

Volumn 35, Issue 8-9, 2004, Pages 785-789

  Taguchi, Masashi ^a   Otsuki, Makoto ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CELL MARKER; CYTOKERATIN 19; NESTIN; TRANSCRIPTION FACTOR PDX 1; BIOLOGICAL MARKER; HOMEODOMAIN PROTEIN; INSULIN PROMOTER FACTOR 1; INTERMEDIATE FILAMENT PROTEIN; NERVE PROTEIN; TRANSACTIVATOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; MALE; MYOFIBROBLAST; NONHUMAN; PANCREAS DUCT; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAT; SPINDLE CELL; STEM CELL; ANIMAL; CYTOLOGY; METABOLISM; PHYSIOLOGY; WISTAR RAT;

ANIMALIA;

ANIMALS; BIOLOGICAL MARKERS; HOMEODOMAIN PROTEINS; INTERMEDIATE FILAMENT PROTEINS; MALE; NERVE TISSUE PROTEINS; PANCREATIC DUCTS; RATS; RATS, WISTAR; STEM CELLS; TRANS-ACTIVATORS;

EID: 16644368589     PISSN: 15672379     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10735-004-0948-9     Document Type: Article

References (22)

1. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE (1993) A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42: 1715-1720.
2. Bonner-Weir S, Sharma A (2002) Pancreatic stem cells. J Pathol 197: 519-526.
3. Gittes GK, Galante PE, Hanahan D, Rutter WJ, Debase HT (1996) Lineage-specific morphogenesis in the developing pancreas: Role of mesenchymal factors. Development 122: 439-447.
4. Gu D, Sarvetnick N (1993) Epithelial cell proliferation and islet neogenesis in IFN-γ transgenic mice. Development 118: 33-46.
5. Guz Y, Montminy MR, Stein R, Leonard J, Gamer LW, Wright CV, Teitelman G (1995) Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 121: 11-18.
6. Hunziker E, Stein M (2000) Nestin-expressing cells in the pancreatic islets of Langerhans. Biochem Biophys Res Commun 271: 116-119.
7. Jonsson J, Carlsson L, Edlund T, Edlund H (1994) Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371: 606-609.
8. Lardon J, Rooman I, Bouwens L (2002) Nestin expression in pancreatic stellate cells and angiogenic endothelial cells. Histochem Cell Biol 117: 535-540.
9. Lendahl U, Zimmerman LB, McKay RD (1990) CNS stem cells express a new class of intermediate filament protein. Cell 60: 585-595.
10. Lumelsky N, Blondel O, Laeng P, Velasco I, Ravin R, McKay R (2001) Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292: 1389-1394.
11. Melloul D, Ben-Neriah Y, Cerasi E (1993) Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. Proc Natl Acad Sci USA 90: 3865-3869.
12. Miralles F, Czernichow P, Ozaki K, Itoh N, Scharfmann R (1999) Signaling through fibroblast growth factor receptor 2b plays a key role in the development of the exocrine pancreas. Proc Natl Acad Sci USA 96: 6267-6272.
13. Morshead CM, Reynolds BA, Craig CG, McBurney MW, Staines WA, Morassutti D, Weiss S, van der Kooy D (1994) Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells. Neuron 13: 1071-1082.
14. Niki T, Pekny M, Hellemans K, Bleser PD, Berg KV, Vaeyens F, Quartier E, Schuit F, Geerts A (1999) Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells. Hepatology 29: 520-527.
15. Ohlsson H, Karlsson K, Edlund T (1993) IPF1, a homeodomain-containing transactivator of the insulin gene. Embo J 12: 4251-4259.
16. Schwitzgebel VM, Scheel DW, Conners JR, Kalamaras J, Lee JE, Anderson DJ, Sussel L, Johnson JD, German MS. (2000) Expression of neurogenin3 reveals an islet cell precursor population in the pancreas. Development 127: 3533-3542.
17. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, and Bonner-Weir S (1999) The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 48: 507-513.
18. Slack JM (1995) Developmental biology of the pancreas. Development 121: 1569-1580.
19. Song SY, Gannon M, Washington MK, Scoggins CR, Meszoely IM, Goldenring JR, Marino CR, Sandgren EP, Coffey RJ, Jr, Wright CV, Leach SD (1999) Expansion of PDX1-expressing pancreatic epithelium and islet neogenesis in transgenic mice overexpressing transforming growth factor alpha. Gastroenterology 117: 1416-1426.
20. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF (1997) Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 15: 106-110.
21. Taguchi M, Yamaguchi T, Otsuki M (2002) Induction of PDX-1-positive cells in the main duct during regeneration after acute necrotizing pancreatitis in rats. J Pathol 197: 638-646.
22. Zulewski H, Abraham EJ, Gerlach MJ, Daniel PB, Moritz W, Muller B, Vallejo M, Thomas MK, Habener JF (2001) Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50: 521-533.