Inhibition of human embryonic palatal mesenchymal cell cycle by secalonic acid D: A probable mechanism of its cleft palate induction

Orthodontics and Craniofacial Research

Volumn 7, Issue 4, 2004, Pages 227-236

  Dhulipala, V C ^a   Welshons, W V ^a   Reddy, C S ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

Cleft palate; Extra cellular matrix; Human embryonic palatal mesenchyme; Proliferation; Secalonic acid D

Indexed keywords

CYCLINE; FIBRONECTIN; GLYCOSAMINOGLYCAN; MYCOTOXIN; SECALONIC ACID; TENASCIN; THYMIDINE; XANTHONE DERIVATIVE;

ANIMAL; ARTICLE; CELL COUNT; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; CLEFT PALATE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; HUMAN; MESODERM; METABOLISM; MOUSE; PALATE; PRENATAL DEVELOPMENT;

ANIMALS; CELL COUNT; CELL CYCLE; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CLEFT PALATE; DOSE-RESPONSE RELATIONSHIP, DRUG; FIBRONECTINS; GLYCOSAMINOGLYCANS; HUMANS; MESODERM; MICE; MYCOTOXINS; PALATE; PROLIFERATING CELL NUCLEAR ANTIGEN; TENASCIN; THYMIDINE; XANTHONES;

EID: 16544390901     PISSN: 16016335     EISSN: 16016343     Source Type: Journal    
DOI: 10.1111/j.1601-6343.2004.00299.x     Document Type: Article

References (24)

1. Slavkin HC. Incidence of cleft lip and palates rising (Review). J Am Dent Assoc 1992;123:61-5.
2. Murray JC. Gene/environment causes of cleft lip and/or palate. Clin Genet 2002;61:248-56.
3. Ehrlich KC, Lee LS, Ciegler A, Palmgren MS. Secalonic acid D: natural contaminant of corn dust. Appl Environ Microbiol 1982;44:1007-8.
4. Reddy CS, Reddy RV, Hayes AW, Ciegler A. Teratogenicity of secalonic acid D in mice. J Toxicol Environ Hlth 1981;7:445-55.
5. Reddy CS, Hayes AW, Williams WL. Toxicity of secalonic acid D in mice. J Toxicol Environ Health 1979;5:1159-69.
6. Steyn PS. The isolation, structure and absolute configuration of secalonic acid D, the toxic metabolite of Penicillium Oxalicum. Tetrahedron 1970;26:51-7.
7. Grain Quality Newsletter. Health hazards of dust and pesticides. Grain Quality Newslett 1983;5:3.
8. Donham KJ. Hazardous agents in agricultural dusts and methods of evaluation. Amer J Indust Med 1986;10:205-20.
9. Eldeib MMR, Reddy CS. A mechanism of dimethylsulfoxide protection against the teratogenecity of secalonic acid in D mice. Teratology 1988;38:418-25.
10. Hanumegowda UM, Judy BM, Welshons WV, Reddy CS. Selective inhibition of murine palatal mesenchymal cell proliferation in vitro by secalonic acid D. Toxicological Sciences 2002;66: 159-65.
11. Balasubramanian G, Amann JF, Reddy CS. Expression and activity of protein kinase C isoenzymes during normal and abnormal murine palate development. J Craniofac Genet Dev Biol 2000;20:26-34.
12. Hanumegowda UM, Dhulipala VC, Reddy CS. Mechanism of Secalonic acid D-induced inhibition of transcription factor binding to cyclic AMP response element in developing murine secondary palate. Toxicol Sci 2002;70:55-62.
13. Welsch F, Stedman DB, Willis WD, Pratt RM. Karyotype, growth, and cell cycle analysis of human embryonic palatal mesenchymal cells: relevance to the use of these cells in an in vitro teratogenicity screening assay. Teratogen Carcinogen Mutagen 1986;6:383-92.
14. Greene RM, Llyod M, Pisano MM. Cyclic AMP-dependent protein kinase in human embryonic palate mesenchymal cells. In vitro Cell Dev Biol 1992;28A:755-62.
15. Bradford MM. A rapid and sensitive method for microgram quantities of protein utilizing the principle of protein dye binding. Anal Biochem 1976;72:248-54.
16. Saarni H, Tammi M. A rapid method for separation assay of radiolabeled mucopolysaccharides from cell culture medium. Anal Biochem 1977;81:40-6.
17. Eldeib MMR, Reddy CS. Secalonic acid D-induced changes in palatal cyclic AMP and cyclic GMP in developing mice. Teratology 1988;37:343-52.
18. Toshiki T. PCNA, a multifunctional ring on DNA. Biochem Biophys Acta 1998;1443:23-9.
19. Pratt RM, Kim CS, Grove RI. Role of glucocorticoids and epidermal growth factor in normal and abnormal palatal development. Curr Topics Dev Biol 1984;19:81-101.
20. HehnBM,IzadnegahdarMF,YoungAV,SangheraJS,PelechSL,Shah RM.In vivoandin vitro assessment of mitogen activated protein kinase involvement during quail secondary palate formation. Anat Rec 1998;252:194-204.
21. Morris-Wiman J, Brinkley L. An extracellular matrix infrastructure provides support for murine secondary palatal shelf remodelling. Anal Rec 1992;234:575-86.
22. Montenegro MA, Rojas M, Dominguez S, Rosales CJ. Differences in extracellular matrix components and cell density during normal and dexamethasone-treated secondary palate development in two strains of mice with different susceptibility to glucocorticoid induced-clefting. J Craniofac Genet Dev Biol 1998;18:100-6.
23. Singh GD, Jhonston J, Ma W, Lozanoff S. Cleft palate formation in fetal Br mice with midfacial retrusion: tenascin, fibronectin, laminin, and type IV collagen immunolocalization. Cleft Palate Craniofac J 1998;35:65-76.
24. Linask KK, D'Angelo M, Geheris AL, Greene RM. Transforming growth factor- β receptor profiles of human and murine embryonic palate mesenchymal cells. Exp Cell Res 1991;192:1-9.