Stereochemistry of NaBH4 reduction of a 19-carbonyl group of 3-deoxy androgens. Synthesis of [19S-3H]- and [19R- 3H]-labeled aromatase inhibitors having a 19-hydroxy group

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 6, 2004, Pages 722-726

  Numazawa, Mitsuteru ^a   Sohtome, Norishige ^a   Nagaoka, Masao ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

19 3H 19 hydroxy androgen; 19 2H 19 hydroxy androgen; Aromatase inhibitor; Isotope labeling; NaB 3H4 reduction; Stereochemistry

Indexed keywords

19 HYDROXY 4 ENE STEROID; 19 HYDROXY 5 ENE STEROID; ANDROGEN; AROMATASE INHIBITOR; CARBONYL DERIVATIVE; HYDROXYL GROUP; UNCLASSIFIED DRUG; AROMATASE; BORANE DERIVATIVE; ENZYME INHIBITOR; HYDROXIDE; HYDROXIDE ION; SODIUM BOROHYDRIDE; TESTOSTERONE DERIVATIVE;

ARTICLE; CHEMICAL REACTION; COMPARATIVE STUDY; ENZYME ACTIVATION; HUMAN; JONES OXIDATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REDUCTION; STEREOCHEMISTRY; CHEMISTRY; METABOLISM; OXIDATION REDUCTION REACTION; STEREOISOMERISM; SYNTHESIS;

AROMATASE; BOROHYDRIDES; ENZYME INHIBITORS; HYDROXIDES; OXIDATION-REDUCTION; STEREOISOMERISM; TESTOSTERONE CONGENERS;

EID: 16544388943     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.722     Document Type: Article

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