Coupling the transcriptional regulatory action of Brn-3b to the cell cycle clock

Cancer Biology and Therapy

Volumn 3, Issue 3, 2004, Pages 324-325

  Zhu, Tao ^a   Sukumar, Saraswati ^a,b  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Breast; Brn 3b; Cancer; CDK4

Indexed keywords

CYCLIN D1; ESTROGEN RECEPTOR ALPHA; MYC PROTEIN; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR POU4F2; UNCLASSIFIED DRUG; CDK4 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 4; DNA BINDING PROTEIN; ONCOPROTEIN; POU4F2 PROTEIN, HUMAN; TRANSCRIPTION FACTOR POU4;

BREAST CANCER; CANCER; CANCER CELL; CARCINOGENESIS; CELL CYCLE; GENE ACTIVATION; HORMONE ACTION; HUMAN; NERVE CELL; NERVE CELL DIFFERENTIATION; NEUROBLASTOMA; NOTE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; BIOSYNTHESIS; BREAST TUMOR; CELL PROLIFERATION; DNA MICROARRAY; FEMALE; GENETICS; PATHOPHYSIOLOGY; UPREGULATION;

BREAST NEOPLASMS; CELL CYCLE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASES; DNA-BINDING PROTEINS; FEMALE; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTO-ONCOGENE PROTEINS; TRANSCRIPTION FACTOR BRN-3; TRANSCRIPTION FACTOR BRN-3B; TRANSCRIPTION FACTORS; UP-REGULATION;

EID: 16544386053     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.3.3.763     Document Type: Note

References (13)

1. Andersen B, Rosenfeld MG. POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease. Endocr Rev 2001; 22:2-35.
2. Liu YZ, Dawson SJ, Latchman DS. Alternative splicing of the Brn-3a and Brn-3b transcription factor RNAs is regulated in neuronal cells. J Mol Neurosci 1996; 7:77-85.
3. Morris PJ, Theil T, Ring CJ, Lillycrop KA, Moroy T, Latchman DS. The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. Mol Cell Biol 1994; 14:6907-14.
4. Budhram-Mahadeo V, Parker M, Latchman DS. POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. Mol Cell Biol 1998; 18:1029-41.
5. Latchman DS. POU family transcription factors in the nervous system. J Cell Physiol 1999; 179:126-33.
6. Xiang M, Gan L, Li D, Zhou L, Chen ZY, Wagner D, et al. Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Cold Spring Harb Symp Quant Biol 1997; 62:325-36.
7. Budhram-Mahadeo V, Ndisang D, Ward T, Weber BL, Latchman DS. The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells. Oncogene 1999; 18:6684-91.
8. Ndisang D, Budhram-Mahadeo V, Pedley B, Latchman DS. The Brn-3a transcription factor plays a key role in regulating the growth of cervical cancer cells in vivo. Oncogene. 2001;20:4899-903.
9. Smith MD, Latchman DS. The functionally antagonistic POU family transcription factors Brn-3a and Brn-3b show opposite changes in expression during the growth arrest and differentiation of human neuroblastoma cells. Int J Cancer 1996; 67:653-60.
10. Dennis JH, Budhram-Mahadeo V, Latchman DS. The Brn-3b POU family transcription factor regulates the cellular growth, proliferation, and anchorage dependence of MCF7 human breast cancer cells. Oncogene 2001; 20:4961-71.
11. Diehl JA. Cycling to cancer with cyclin D1. Cancer Biol Ther 2002; 1:226-31.
12. Doisneau-Sixou SF, Sergio CM, Carroll JS, Hui R, Musgrove EA, Sutherland RL. Estrogen and antiestrogen regulation of cell cycle progression in breast cancer cells. Endocr Relat Cancer 2003; 10:179-86.
13. Fan S, Wang J, Yuan R, Ma Y, Meng Q, Erdos MR, et al. BRCA1 inhibition of estrogen receptor signaling in transfected cells. Science 1999; 284:1354-6.