Glycobiology and cancer: Meeting summary and future directions

Cancer Biology and Therapy

Volumn 3, Issue 2, 2004, Pages 233-237

  Hart, Gerald W ^a   Lowe, John B ^b   Sathyamoorthy, Neeraja ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Angiogenesis; Extracellular matrix; Glycoconjugates; Glycoproteins; Glycosphingolipids; Metalloproteinases; Metastasis; Mucins; Proteoglycans; Selectins

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GANGLIOSIDE GD2; GLYCOCONJUGATE; GLYCOSPHINGOLIPID; GLYPICAN; HERMES ANTIGEN; HYALURONIC ACID; MATRIX METALLOPROTEINASE; MUCIN; N ACETYLGLUCOSAMINYLTRANSFERASE; PADGEM PROTEIN; PERLECAN; PROTEOHEPARAN SULFATE; SELECTIN; SIALYL LEWIS X ANTIGEN; SYNDECAN 1; CARBOHYDRATE; GLYCOPROTEIN; OLIGOSACCHARIDE; POLYSACCHARIDE;

ANGIOGENESIS; APOPTOSIS; CANCER; CANCER INVASION; CELL ADHESION; CONFERENCE PAPER; EXTRACELLULAR MATRIX; GENETIC ANALYSIS; GLYCOBIOLOGY; HUMAN; METASTASIS; MOLECULAR MECHANICS; NONHUMAN; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN DEGRADATION; THROMBOCYTE; TUMOR CELL; TUMOR GROWTH; ANIMAL; CHEMISTRY; FORECASTING; GENERAL ASPECTS OF DISEASE; METABOLISM;

ANIMALS; CARBOHYDRATES; DISEASE; FORECASTING; GLYCOPROTEINS; HUMANS; OLIGOSACCHARIDES; POLYSACCHARIDES;

EID: 16544382485     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.3.2.775     Document Type: Conference Paper

References (41)

1. Stetler-Stevenson WG. The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis. Surg Oncol Clin N Am 2001; 10:383-92.
2. Stetler-Stevenson WG, Yu AE. Proteases in invasion: matrix metalloproteinases. Semin Cancer Biol 2001; 11:143-52.
3. Wong CW, Song C, Grimes MM, Fu W, Dewhirst MW, Muschel RJ, Al-Mehdi AB. Intravascular location of breast cancer cells after spontaneous metastasis to the lung. Am J Pathol 2002; 161:749-53.
4. Zimrin AB, Pepper MS, McMahon GA, Nguyen F, Montesano R, Maciag T. An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro. J Biol Chem 1996; 271:32499-502.
5. Small D, Kovalenko D, Soldi R, Mandinova A, Kolev V, Trifonova R, Bagala C, Kacer D, Battelli C, Liaw L, Prudovsky I, Maciag T. Notch activation suppresses fibroblast growth factor-dependent cellular transformation. J Biol Chem 2003; 278:16405-13.
6. Sarkar AK, Brown JR, Esko JD. Synthesis and glycan priming activity of acetylated disaccharides. Carbohydr Resb 2000; 329:287-300.
7. Sarkar AK, Rostand KS, Jain RK, Matta KL, Esko JD. Fucosylation of disaccharide precursors of sialyl LewisX inhibit selectin-mediated cell adhesion. J Biol Chem 1997; 272:25608-16.
8. Mongiat M, Sweeney S, San Antonio JD, Fu J, Iozzo RV. Endorepellin, a novel inhibitor of angiogenesis derived from the carboxyl terminus of perlecan. J Biol Chem 2003; 278:4238-49.
9. Iozzo RV, San Antonio JD. Heparan sulfate proteoglycans: heavy hitters in the angiogenesis arena. J Clin Invest 2001; 108:349-55.
10. Iozzo RV. Heparan sulfate proteoglycans: intricate molecules with intriguing functions. J Clin Invest 2001; 108:165-7.
11. Bourguignon LY, Singleton PA, Zhu H, Zhou B. Hyaluronan promotes signaling interaction between CD44 and the transforming growth factor beta receptor I in metastatic breast tumor cells. J Biol Chem 2002; 277:39703-12.
12. Turley EA, Noble PW, Bourguignon LY. Signaling properties of hyaluronan receptors. J Biol Chem 2002; 277:4589-92.
13. Toole BP, Hascall VC. Hyaluronan and tumor growth. Am J Pathol 2002; 161:745-7.
14. Ghatak S, Misra S, Toole BP. Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway. J Biol Chem 2002; 277:38013-20.
15. Toole BP. Hyaluronan promotes the malignant phenotype. Glycobiology 2002; 12:37R-42R.
16. Ju T, Brewer K, D'Souza A, Cummings RD, Canfield WM. Cloning and expression of human core 1 beta1,3-galactosyltransferase. J Biol Chem 2002; 277:178-86.
17. Ju T, Cummings RD. A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase. Proc Natl Acad Sci USA 2002; 99:16613-8.
18. Yu, Q., and Stamenkovic, I. Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasion. Genes Dev 1999; 13:35-48.
19. Yu WH, Woessner JF Jr, McNeish JD, Stamenkovic I. CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes Dev 2002; 16:307-23.
20. Stamenkovic I. Matrix metalloproteinases in tumor invasion and metastasis. Semin Cancer Biol 2000; 10:415-33.
21. Ahmed F, Wyckoff J, Lin EY, Wang W, Wang Y, Hennighausen L, Miyazaki J, Jones J, Pollard JW, Condeelis JS, Segall JE. GFP Expression in the mammary gland for imaging of mammary tumor cells in transgenic mice. Cancer Res 2002; 62:7166-9.
22. Condeelis JS, Wyckoff J, Segall JE. Imaging of cancer invasion and metastasis using green fluorescent protein. Eur J Cancer 2000; 36:1671-80.
23. Wyckoff JB, Jones JG, Condeelis JS, Segall JE. A critical step in metastasis: in vivo analysis of intravasation at the primary tumor. Cancer Res 2000; 60:2504-11.
24. Zhang J, Nakayama J, Ohyama C, Suzuki M, Suzuki A, Fukuda M, Fukuda MN. Sialyl Lewis X-dependent lung colonization of B16 melanoma cells through a selectin-like endothelial receptor distinct from E- or P-selectin. Cancer Res 2002; 62:4194-8.
25. Ohyama C, Tsuboi S, Fukuda M. Dual roles of sialyl Lewis X oligosaccharides in tumor metastasis and rejection by natural killer cells. EMBO J 199; 18:1516-25.
26. Ohyama C, Kanto S, Kato K, Nakano O, Arai Y, Kato T, Chen S, Fukuda MN, Fukuda M. Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides. Proc Natl Acad Sci USA 2002; 99:13789-94.
27. Pierce M, Buckhaults P, Chen L, Fregien N. Regulation of N-acetylglucosaminyltransferase V and Asn-linked oligosaccharide beta(1,6) branching by a growth factor signaling pathway and effects on cell adhesion and metastatic potential. Glycoconj J 1997; 14:623-30.
28. Dennis JW, Pawling J, Cheung P, Partridge E, Demetriou M. UDP-N-acetylglucosamine:alpha-6-D-mannoside beta1,6 N- acetylglucosaminyltransferase V (Mgat5) deficient mice. Biochim Biophys Acta 2002; 1573:414-22.
29. Granovsky M, Fata J, Pawling J, Muller WJ, Khokha R, Dennis JW. Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nat Med 2000; 6:306-12.
30. Dennis JW, Granovsky M, Warren CE. Glycoprotein glycosylation and cancer progression. Biochim Biophys Acta 1999; 1473:21-34.
31. Yin BW, Dnistrian A, Lloyd KO. Ovarian cancer antigen CA125 is encoded by the MUC16 mucin gene. Int J Cancer 2002; 98:737-40.
32. Taylor-Papadimitriou J, Burchell JM, Plunkett T, Graham R, Correa I, Miles D, Smith M. MUC1 and the immunobiology of cancer. J Mammary Gland Biol Neoplasia 2002; 7:209-21.
33. Burchell JM, Mungul A, Taylor-Papadimitriou J. O-linked glycosylation in the mammary gland: changes that occur during malignancy. J Mammary Gland Biol Neoplasia 2001; 6:355-64.
34. Price-Schiavi SA, Jepson S, Li P, Arango M, Rudland PS, Yee L, Carraway KL. Rat Muc4 (sialomucin complex) reduces binding of anti-ErbB2 antibodies to tumor cell surfaces, a potential mechanism for herceptin resistance. Int J Cancer 2002; 99:783-91.
35. Schwientek T, Bennett EP, Flores C, Thacker J, Hollmann M, Reis CA, Behrens J, Mandel U, Keck B, Schafer MA, Haselmann K, Zubarev R, Roepstorff P, Burchell JM, Taylor-Papadimitriou J, Hollingsworth MA, Clausen H. Functional conservation of subfamilies of putative UDP-N acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila. J Biol Chem 2002; 277:22623-38.
36. Hakomori S, Handa K. Glycosphingolipid-dependent cross-talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy. FEBS Lett 2002; 531: 88-92.
37. Hakomori S. The glycosynapse. Proc Natl Acad Sci USA 2002; 99: 225-32.
38. Dolo V, Li R, Dillinger M, Flati S, Manela J, Taylor BJ, Pavan A, Ladisch S. Enrichment and localization of ganglioside G(D3) and caveolin-1 in shed tumor cell membrane vesicles. Biochim Biophys Acta 2000; 1486:265-74.
39. Kong Y, Li R, Ladisch S. Natural forms of shed tumor gangliosides. Biochim Biophys Acta 1998; 1394:43-56.
40. Yang Y, Yaccoby S, Liu W, Langford JK, Pumphrey CY, Theus A, Epstein J, Sanderson RD. Soluble syndecan-1 promotes growth of myeloma tumors in vivo. Blood 2002; 100:610-7.
41. Sanderson RD. Heparan sulfate proteoglycans in invasion and metastasis. Semin Cell Dev Biol 2001; 12:89-98.