Impaired reproduction in transgenic mice overexpressingγ-aminobutyric acid transporter I (GAT1)

Cell Research

Volumn 14, Issue 1, 2004, Pages 54-59

  Hu, Jia Hua ^a   Zhang, Jin Fu ^b   Ma, Ying Hua ^a   Jiang, Jie ^a   Yang, Na ^a   Li, Xin Bo ^c   Yu Chi, Zhi Guang ^d   Fei, Jian ^a,e   Guo, Li He ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b TONGJI UNIVERSITY   (China)

^c North China Pharmaceutical Corporation   (China)

^d FUDAN UNIVERSITY   (China)

^e Shanghai Nan Fang Model Organism Research Center   (China)

Author keywords

GABA; GAT1; Reproduction; Sperm; Testes; Transgenic

Indexed keywords

MUS MUSCULUS;

4 AMINOBUTYRIC ACID CARRIER; ANDROGEN RECEPTOR; CARRIER PROTEIN; RNA; SLC6A1 PROTEIN, MOUSE; TESTOSTERONE;

ANIMAL; ARTICLE; BLOOD; BREEDING; CHEMISTRY; FEMALE; FERTILITY; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; ISOLATION AND PURIFICATION; LEYDIG CELL; LITTER SIZE; MALE; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; REPRODUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINIFEROUS TUBULE; SPERMATOGENESIS; SPERMATOZOON; TESTIS; TRANSGENIC MOUSE;

ANIMALS; BREEDING; FEMALE; FERTILITY; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GENE EXPRESSION; LEYDIG CELLS; LITTER SIZE; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, TRANSGENIC; RECEPTORS, ANDROGEN; REPRODUCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; SEMINIFEROUS TUBULES; SPERMATOGENESIS; SPERMATOZOA; TESTIS; TESTOSTERONE;

EID: 16544375388     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/sj.cr.7290202     Document Type: Article

References (21)

1. Krnjevic K. Chemical nature of synaptic transmission in vertebrates. Physiol Rev 1974; 54:418-40.
2. Radian R, Ottersen OP, Mathisen-Storm J, Gastel M, Kanner BI Immunocytochemical localization of the GABA transporter in rat brain. J Neurosci 1990; 10:1319-30.
3. Pietrini G, Suh YJ, Edelmann L, Rudnick G, Caplan MJ The axonal γ-aminobutyric acid transporter GAT-1 is sorted to the apical membranes of polarized epithelial cells. J Biol Chem 1994; 269:4668-74.
4. Erdö SL, Wolff JR. γ-aminobutyric acid outside the mammalian brain. J Neurochem 1990; 54:363-72.
5. Erdö SL, Nemet L, Szporny L. The occurrence of GABA in vas deferens, prostate, epididymis, seminal vesicle and testicle of the rat. Acta Biol Hung 1983; 34:435.
6. Orensanz LM, Fernandez I, Martin del Rio R, Storm-Mathisen J. Gamma-aminobutyric acid in the rat oviduct. Adv Biochem Psychopharmacol 1986; 42:265-74.
7. Castelli MP, Ingianni A, Stefanini E, Gessa GL. Distribution of GABA(B) receptor mRNAs in the rat brain and peripheral organs. Life Sci 1999; 64:1321-8.
8. B receptor in rat testis and sperm. Biochem Biophys Res Commu. 2001; 283:243-7.
9. Hu JH, Yan YC. Identification of gamma1 subunit of GABA(A) receptor in rat testis. Cell Res 2002; 12:33-7.
10. Shi QX, Roldan ER. Evidence that GABAA-like receptor is involved in progesterone-induced acrosome reaction exocytosis in mouse spermatozoa. Biol Reprod 1995; 52:373-81.
11. Calogero AE, Burrello N, Ferrara E, Hall J, Fishel S, D'Agata R. Gamma-aminobutyric acid (GABA) A and B receptors mediated the stimulatory effects of GABA on the human sperm acrosome reaction: Interaction with progesterone. Fertil Steril 1999; 71: 930-6.
12. Hu JH, He XB, Wu Q, Yan YC Koide SS. Biphasic effect of GABA on rat sperm acrosome resction: involvement of GABA (A) and GABA(B) receptors. Arch Androl 2002; 48: 369-378.
13. Aanesen A, Fried G, Andersson E, Gottlieb C. Evidence for gamma-aminobutyric acid specific binding sites on human spermatozoa. Hum Repeod 1995; 10:1885-90.
14. Aanesen A, Fried G, Andersson E, Gottlieb C. Carrier-mediated γ-aminobutyric acid uptake in human spermatozoa indicating the presence of a high-affinity γ-aminobutyric acid transporter protein. Biol Reprod 1996; 54:841-6.
15. Ma YH, Hu JH, Zhou XG, Mei ZT, Fei J, Guo LH. γ-aminobutyric acid transporter (GAT1) overexpression in mouse affects the testicular morphology. Cell Res 2000; 10:59-69.
16. Hu JH, He XB, Yan YC. Identification of γ-aminobutyric acid transporter (GAT1) on the rat sperm. Cell Res 2000; 10:51-8.
17. Var ju P, Katarova Z, Madarasz E, Szabo G. GABA signaling during development: new data and old questions. Cell Tissue Res 2001; 305:239-46.
18. Calogero AE, Hall J, Fishel S, Green S, Hunter A, D'Agata R. Effects of gamma- aminobutyric acid on human sperm motility and hyperactivation. Mol hum Reprod 1996; 2:733-8.
19. Shi QX, Yuan YY, Roldan ER. Gamma-Aminobutyric acid (GABA) induces the acrosome reaction in human spermatozoa. Mol Hum Reprod 1997; 3:677-83.
20. Mager S, Naeve J, Quick M, Labarca C, Davidson N, Letter HA. Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes. Neuron 1993; 10: 177-88.
21. Florman HM, Arnoult C, Hazam IG, Li C, Christine MB, O'Toole. A perspective on the control of mammalian fertilization by egg-activated ion channels in sperm: a tale of two channels. Biol Reprod 1998; 59:12-6.