Asymmetric Michael reaction promoted by new chiral phase-transfer catalysts

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 5, 2004, Pages 646-648

  Arai, Shigeru ^a,b   Tokumaru, Kazuyuki ^a   Aoyama, Toyohiko ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Asymmetric synthesis; Chiral ammonium salt; Michael reaction; Phase transfer catalysis

Indexed keywords

AROMATIC COMPOUND; QUATERNARY AMMONIUM DERIVATIVE;

ARTICLE; ASYMMETRIC CATALYSIS; CATALYST; CHIRALITY; ENANTIOSELECTIVITY; MICHAEL ADDITION; CATALYSIS; CHEMISTRY; METABOLISM; PHASE TRANSITION; STEREOISOMERISM;

CATALYSIS; PHASE TRANSITION; QUATERNARY AMMONIUM COMPOUNDS; STEREOISOMERISM;

EID: 16544367097     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.646     Document Type: Article

References (18)

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17. 4. The solvents were removed in vacuo and subsequent flash column chromatography (hexane: AcOEt=5:1) gave the desired product 8b (39 mg, 100%, 75% ee). The enantiomeric excess was determined by HPLC [CHIRALCEL OD, hexane: i-PrOH=50:1, flow rate: 1.0 ml/min (254 nm), retention times: 7.8 min (minor), 9.1 min (major)].
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