Ex Vivo and in Vivo Biological Effects of a Truncated Form of the Receptor Tyrosine Kinase Stk When Activated by Interaction with the Friend Spleen Focus-Forming Virus Envelope Glycoprotein or by Point Mutation

Journal of Virology

Volumn 78, Issue 9, 2004, Pages 4573-4581

  Rulli, Karen ^a   Yugawa, Takashi ^a   Hanson, Charlotte ^a   Thompson, Delores ^a   Ruscetti, Sandra ^a   Nishigaki, Kazuo ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENVELOPE PROTEIN; ERYTHROPOIETIN; GLYCOPROTEIN GP 55; RETROVIRUS VECTOR; STK TYROSINE KINASE RECEPTOR; TYROSINE; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; COLONY FORMING UNIT; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME METABOLISM; ERYTHROID CELL; ERYTHROLEUKEMIA; FRIEND LEUKEMIA VIRUS; MOUSE; MOUSE MUTANT; MUTATIONAL ANALYSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RETROVIRUS; SPLEEN FOCUS FORMING VIRUS;

ANIMALS; CELL LINE; ERYTHROID CELLS; ERYTHROPOIETIN; GENETIC VECTORS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; MICE, INBRED C57BL; POINT MUTATION; RECEPTOR PROTEIN-TYROSINE KINASES; RETROVIRIDAE INFECTIONS; SPLEEN FOCUS-FORMING VIRUSES; TUMOR VIRUS INFECTIONS; VIRAL ENVELOPE PROTEINS;

EID: 16544364503     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.78.9.4573-4581.2004     Document Type: Article

References (24)

1. Chiara, F., P. Michieli, L. Pugliese, and P. M. Comoglio. 2003. Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity. J. Biol. Chem. 278:29352-29358.
2. Danilkovitch-Miagkova, A., and E. J. Leonard. 2001. Cross-talk between RON receptor tyrosine kinase and other transmembrane receptors. Histol. Histopathol. 16:623-631.
3. Di Renzo, M. F., M. Olivero, S. Ferro, M. Prat, I. Bongarzone, S. Pilotti, A. Belfiore, A. Costantino, R. Vigneri, M. A. Pierotti, and P. M. Comoglio. 1992. Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas. Oncogene 7:2549-2553.
4. Di Renzo, M. F., M. Olivero, D. Katsaros, T. Crepaldi, P. Gaglia, P. Zola, P. Sismondi, and P. M. Comoglio. 1994. Overexpression of the Met/HGF receptor in ovarian cancer. Int. J. Cancer 58:658-662.
5. Finkelstein, L. D., P. A. Ney, Q. P. Liu, R. F. Paulson, and P. H. Correll. 2002. Sf-Stk kinase activity and the Grb2 binding site are required for Epo-independent growth of primary erythroblasts infected with Friend virus. Oncogene 21:3562-3570.
6. Hasenkrug, K. J. 1999. Lymphocyte deficiencies increase susceptibility to Friend virus-induced erythroleukemia in Fv-2 genetically resistant mice. J. Virol. 73:6468-6473.
7. Iwama, A., N. Yamaguchi, and T. Suda. 1996. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. EMBO J. 15:5866-5875.
8. Jeffers, M., L. Schmidt, N. Nakaigawa, C. P. Webb, G. Weirich, T. Kishida, B. Zbar, and G. F. Vande Woude. 1997. Activating mutations for the met tyrosine kinase receptor in human cancer. Proc. Natl. Acad. Sci. USA 94: 11445-11450.
9. Melkun, E., M. Pilione, and R. F. Paulson. 2002. A naturally occurring point substitution in Cdc25A, and not Fv2/Stk, is associated with altered cell-cycle status of early erythroid progenitor cells. Blood 100:3804-3811.
10. Muszynski, K. W., T. Ohashi, C. Hanson, and S. K. Ruscetti. 1998. Both the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus induce constitutive activation of the Raf-1/mitogen-activated protein kinase signal transduction pathway. J. Virol. 72:919-925.
11. Ney, P. A., and A. D. D'Andrea. 2000. Friend erythroleukemia revisited. Blood 96:3675-3680.
12. Nishigaki, K., C. Hanson, T. Ohashi, D. Thompson, K. Muszynski, and S. Ruscetti. 2000. Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: involvement of insulin receptor substrate-related adapter proteins. J. Virol. 74:3037-3045.
13. Nishigaki, K., D. Thompson, C. Hanson, T. Yugawa, and S. Ruscetti. 2001. The envelope glycoprotein of Friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk. J. Virol. 75:7893-7903.
14. Ohashi, T., M. Masuda, and S. K. Ruscetti. 1995. Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus. Blood 85:1454-1462.
15. Olbrich, A., S. Schimmer, and U. Dittmer. 2003. Preinfection treatment of resistant mice with CpG oligodeoxynucleotides renders them susceptible to Friend retrovirus-induced leukemia. J. Virol. 77:10658-10662.
16. Pear, W. S., G. P. Nolan, M. L. Scott, and D. Baltimore. 1993. Production of high-titer helper-free retroviruses by transient transfection. Proc. Natl. Acad. Sci. USA 90:8392-8396.
17. Persons, D. A., R. F. Paulson, M. R. Loyd, M. T. Herley, S. M. Bodner, A. Bernstein, P. H. Correll, and P. A. Ney. 1999. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nat. Genetics 23:159-165.
18. Ruscetti, S. K. 1999. Deregulation of erythropoiesis by the Friend spleen focus-forming virus. Int. J. Biochem. Cell Biol. 31:1089-1109.
19. Schmidt, L., F. M. Duh, F. Chen, T. Kishida, G. Glenn, P. Choyke, S. W. Scherer, Z. Zhuang, I. Lubensky, M. Dean, R. Allikmets, A. Chidambaram, U. R. Bergerheim, J. T. Feltis, C. Casadevall, A. Zamarron, M. Bernues, S. Richard, C. J. Lips, M. M. Walther, L. C. Tsui, L. C. Geil, M. L. Orcutt, T. Stackhouse, and B. Zbar. 1997. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat. Genetics 16:68-73.
20. Van der Gaag, H. C., and A. A. Axelrad. 1990. Friend virus replication in normal and immunosuppressed C57BL/6 mice. Virology 177:837-839.
21. Williams, T. A., P. Longati, L. Pugliese, P. Gual, A. Bardelli, and P. Michieli. 1999. MET(PRC) mutations in the Ron receptor result in upregulation of tyrosine kinase activity and acquisition of oncogenic potential. J. Cell Physiol. 181:507-514.
22. Wolff, L., R. Koller, and S. Ruscetti. 1982. Monoclonal antibody to spleen focus-forming virus-encoded gp52 provides a probe for the amino-terminal region of retroviral envelope proteins that confers dual tropism and xenotropism. J. Virol. 43:472-481.
23. Xiao, Z. Q., Y. Q. Chen, and M. H. Wang. 2000. Requirement of both tyrosine residues 1330 and 1337 in the C-terminal tail of the RON receptor tyrosine kinase for epithelial cell scattering and migration. Biochem. Biophys. Res. Commun. 267:669-675.
24. Yoshimura, A., A. D. D'Andrea, and H. F. Lodish. 1990. Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism. Proc. Natl. Acad. Sci. USA 87:4139-4143.