The envelope glycoprotein of Friend spleen focus-forming virus covalently interacts with and constitutively activates a truncated form of the receptor tyrosine kinase Stk

Journal of Virology

Volumn 75, Issue 17, 2001, Pages 7893-7903

  Nishigaki, K ^a   Thompson, D ^a   Hanson, C ^a   Yugawa, T ^a   Ruscetti, S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; PROTEIN TYROSINE KINASE; VIRUS ENVELOPE PROTEIN; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ARTICLE; COVALENT BOND; DISULFIDE BOND; ENZYME ACTIVATION; ERYTHROID CELL; ERYTHROLEUKEMIA; ERYTHROLEUKEMIA CELL; FRIEND LEUKEMIA VIRUS; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; LEUKEMIA, EXPERIMENTAL; MICE; MUTATION; PHOSPHORYLATION; PLASMIDS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CELL SURFACE; RECEPTORS, ERYTHROPOIETIN; RETROVIRIDAE INFECTIONS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SPLEEN FOCUS-FORMING VIRUSES; TUMOR CELLS, CULTURED; TUMOR VIRUS INFECTIONS; TYROSINE; VIRAL ENVELOPE PROTEINS;

EID: 0034877772     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.17.7893-7903.2001     Document Type: Article

References (50)

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4. Multimeric structure of the membrane erythropoietin receptor of murine erythroleukemia cells (Friend cells)
5. Transmembrane domain of the envelope gene of a polycythemia-inducing retrovirus determines erythropoietin-independent growth
6. Complete nucleotide sequences of an infectious clone of Friend spleen focus-forming provirus: gp55 is an envelope fusion glycoprotein
7. Deregulated inflammatory response in mice lacking the STK/RON receptor tyrosine kinase
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10. The proto-oncogene c-Cbl is a positive regulator of Met-induced MAP kinase activation: A role for the adaptor protein Crk
11. Ron is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP
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13. Influence of Fv-1 and Fv-2 gene systems on in vitro erythroid transformation by Friend leukemia virus
14. Deletions in one domain of the Friend virus-encoded membrane glycoprotein overcome host range restrictions for erythroleukemia
15. Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells
16. Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophage-stimulating protein
17. STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family
18. rr host resistance encodes a small glycoprotein that dimerizes, is processed to cell surfaces, and specifically activates erythropoietin receptors
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22. Localization of the intrachain disulfide bonds of the envelope glycoprotein 71 from Friend murine leukemia virus
23. Structural elements in glycoprotein 70 from polytropic Friend mink cell focus-inducing virus and glycoprotein 71 from ecotropic Friend murine leukemia virus, as defined by disulfide-bonding pattern and limited proteolysis
24. r-mediated resistance to Friend virus-induced erythroleukemia
25. Both the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus induce constitutive activation of the Raf-1/mitogen-activated protein kinase signal transduction pathway
26. Growth factor-independent proliferation of erythroid cells infected with Friend spleen focus-forming virus is protein kinase C dependent but does not require Ras-GTP
27. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356
28. Erythroid cells rendered erythropoietin independent by infection with Friend spleen focus-forming virus show constitutive activation of phosphatidylinositol 3-kinase and Akt kinase: Involvement of insulin receptor substrate-related adapter proteins
29. Induction of sequence-specific DNA-binding factors by erythropoietin and the spleen focus-forming virus
30. IL-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo
31. Production of high-titer helper-free retroviruses by transient transfection
32. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase
33. A novel putative receptor protein tyrosine kinase of the met family
34. Characterization of a protein found in cells infected with the spleen focus-forming virus that shares immunological cross-reactivity with the gp70 found in mink cell focus-inducing virus particles
35. Friend spleen focus-forming virus induces factor independence in an erythropoietin-dependent erythroleukemia cell line
36. Deregulation of erythropoiesis by the Friend spleen focus-forming virus
37. Heterogeneous metabolism and subcellular localization of a potentially leukemogenic membrane glycoprotein encoded by Friend erythroleukemia virus
38. r bone marrow
39. Membrane association and defective transport of spleen focus-forming virus glycoproteins
40. Src homology 2-containing inositol 5-phosphatase 1 binds to the multifunctional docking site of c-Met and potentiates hepatocyte growth factor-induced branching tubulogenesis
41. Fv-2 locus controls the proportion of erythropoietic progenitor cells (BFU-E) synthesizing DNA in normal mice
42. Identification of the ron gene product as the receptor for the human macrophage-stimulating protein
43. The murine stk gene product, a transmembrane protein tyrosine kinase, is a receptor for macrophage-stimulating protein
44. Erythropoietin receptor (EpoR)-dependent mitogenicity of spleen focus-forming virus correlates with viral pathogenicity and processing of env protein but not with formation of gp52-EpoR complexes in the endoplasmic reticulum
45. Signal transduction in the erythropoietin receptor system
46. Monoclonal antibody to spleen focus-forming virus-encoded gp52 provides a probe for the amino-terminal region of retroviral envelope proteins that confers dual tropism and xenotropism
47. Envelope gene of the Friend spleen focus-forming virus: Deletion and insertions in 3′ gp70/p15E-encoding region have resulted in unique features in the primary structure of its protein product
48. Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism
49. Impaired activation and binding of the erythropoietin receptor by a mutant gp55 of Friend spleen focus-forming virus, which has a cytoplasmic domain