The effect of clozapine on factors controlling glucose homeostasis

Journal of Clinical Psychiatry

Volumn 65, Issue 10, 2004, Pages 1352-1355

  Howes, Oliver D ^a   Gaughran, Fiona P ^a   Amiel, Stephanie A ^b   Murray, Robin M ^a   Pilowsky, Lyn S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; HUMAN GROWTH HORMONE; NEUROLEPTIC AGENT; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN C;

ADULT; ARTICLE; BLOOD; BODY MASS; CHEMOLUMINESCENCE; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; HUMAN; IMMUNOASSAY; MALE; METABOLISM; PHYSIOLOGY; PROSPECTIVE STUDY; SCHIZOPHRENIA;

ADULT; ANTIPSYCHOTIC AGENTS; BLOOD GLUCOSE; BODY MASS INDEX; CHEMILUMINESCENT MEASUREMENTS; CLOZAPINE; FEMALE; HOMEOSTASIS; HUMAN GROWTH HORMONE; HUMANS; IMMUNOASSAY; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 1; INSULIN-LIKE GROWTH FACTOR I; MALE; PROSPECTIVE STUDIES; SCHIZOPHRENIA;

EID: 16544363627     PISSN: 01606689     EISSN: None     Source Type: Journal    
DOI: 10.4088/JCP.v65n1009     Document Type: Article

References (19)

1. Kane J, Honigfeld G, Singer J, et al. Clozapine for the treatment-resistant schizophrenic: a double-blind comparison with chlorpromazine. Arch Gen Psychiatry 1988;45:789-796 (Pubitemid 18222922)
2. Koller E, Schneider B, Bennett K, et al. Clozapine-associated diabetes. Am J Med 2001;111:716-723 (Pubitemid 34017524)
3. Sernyak MJ, Leslie DL, Alarcon RD, et al. Association of diabetes mellitus with use of atypical neuroleptics in the treatment of schizophrenia. Am J Psychiatry 2002;159:561-566 (Pubitemid 34274937)
4. Lund BC, Perry PJ, Brooks JM, et al. Clozapine use in patients with schizophrenia and the risk of diabetes, hyperlipidemia, and hypertension: a claims-based approach. Arch Gen Psychiatry 2001;58:1172-1176 (Pubitemid 33121510)
5. Wang PS, Glynn RJ, Ganz DA, et al. Clozapine use and risk of diabetes mellitus. J Clin Psychopharmacol 2002;22:236-243 (Pubitemid 34546837)
6. Hägg S, Joelsson L, Mjörndal T, et al. Prevalence of diabetes and impaired glucose tolerance in patients treated with clozapine compared with patients treated with conventional depot neuroleptic medications. J Clin Psychiatry 1998;59:294-299 (Pubitemid 28353977)
7. Henderson DC, Cagliero E, Gray C, et al. Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study. Am J Psychiatry 2000;157:975-981 (Pubitemid 30412350)
8. Newcomer JW, Haupt DW, Fucetola R, et al. Abnormalities in glucose regulation during antipsychotic treatment of schizophrenia. Arch Gen Psychiatry 2002;59:337-345 (Pubitemid 34275252)
9. Howes OD, Bhatnagar A, Gaughran FP, et al. A prospective study of impairment in glucose control caused by clozapine without changes in insulin resistance. Am J Psychiatry 2004;161:361-363 (Pubitemid 38419289)
10. Sandhu MS, Heald AH, Gibson JM, et al. Circulating concentrations of insulin-like growth factor-I and development of glucose intolerance: a prospective observational study. Lancet 2002;359:1740-1745 (Pubitemid 34607089)
11. Nyomba BL, Berard L, Murphy LJ. Free insulin-like growth factor I (IGF-I) in healthy subjects: relationship with IGF-binding proteins and insulin sensitivity. J Clin Endocrinol Metab 1997;82:2177-2181 (Pubitemid 27287580)
12. Lewitt MS. Role of the insulin-like growth factors in the endocrine control of glucose homeostasis. Diabetes Res Clin Pract 1994;23:3-15 (Pubitemid 24118509)
13. Holt RI, Simpson HL, Sonksen PH. The role of the growth hormone-insulin-like growth factor axis in glucose homeostasis. Diabet Med 2003; 20:3-15 (Pubitemid 36098860)
14. Lund BC, Perry PJ, Brooks JM, et al. Clozapine use in patients with schizophrenia and the risk of diabetes, hyperlipidemia, and hypertension: a claims-based approach. Arch Gen Psychiatry 2001;58:1172-1176 (Pubitemid 33121510)
15. Melkersson KI, Hulting A-L, Brismar KE. Different influences of classical antipsychotics and clozapine on glucose-insulin homeostasis in patients with schizophrenia or related psychoses. J Clin Psychiatry 1999;60:783-791
16. McCarthy PT, Hughes S, Paton C. Measurement of clozapine and norclozapine in plasma/serum by high performance liquid chromatography with ultraviolet detection. Biomed Chromatogr 1995;9:36-41
17. Melkersson KI, Hulting A-L, Brismar KE. Elevated levels of insulin, leptin, and blood lipids in olanzapine-treated patients with schizophrenia or related psychoses. J Clin Psychiatry 2000;61:742-749 (Pubitemid 30809944)
18. Dwyer DS, Pinkofsky HB, Liu Y, et al. Antipsychotic drugs affect glucose uptake and the expression of glucose transporters in PC12 cells. Prog Neuropsychopharmacol Biol Psychiatry 1999;23:69-80 (Pubitemid 29098903)
19. Ardizzone TD, Bradley RJ, Freeman AM III, et al. Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine. Brain Res 2001;923: 82-90 (Pubitemid 34024939)