A Novel Approach Based on Solid Phase Microextraction Gas Chromatography and Mass Spectrometry to the Determination of Highly Reactive Organic Compounds in Cells Cultures: Styrene Oxide

Chemical Research in Toxicology

Volumn 17, Issue 1, 2004, Pages 104-109

  Poli, Diana ^a   Vettori, Maria Vittoria ^a   Manini, Paola ^a   Andreoli, Roberta ^a   Alinovi, Rossella ^a   Ceccatelli, Sandra ^b   Mutti, Antonio ^a  

^a UNIVERSITY OF PARMA   (Italy)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; ORGANIC COMPOUND; POLYACRYLIC ACID; STYRENE OXIDE;

ACCURACY; ARTICLE; CALCULATION; CELL CULTURE; CELL FREE SYSTEM; CELL LINE; CULTURE MEDIUM; GAS CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NEUROBLASTOMA CELL; SOLID PHASE MICROEXTRACTION; SUPERNATANT; TANDEM MASS SPECTROMETRY; TIME; VALIDATION PROCESS;

ACRYLATES; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA; DIMETHYL SULFOXIDE; DIMETHYLPOLYSILOXANES; EPOXY COMPOUNDS; ETHYLENE GLYCOLS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; NEUROBLASTOMA; POLYMERS; REPRODUCIBILITY OF RESULTS; SILICONES; SOLUBILITY;

EID: 1642579634     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx034159b     Document Type: Article

References (22)

1. Blaauboer, B. J., Balls, M., Barratt, M., Casati, S., Coecke, S., Mohamed, M. K., Moore, J., Rall, D., Smith, K. R., Tennant, R., Schwetz, B. A., Stokes, W. S., and Younes, M. (1998) 13th meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC): alternative testing methodologies and conceptual issues. Environ. Health Perspect. 106 (Suppl. 2), 413-418.
2. Blaauboer, J. B. (2001) Toxicodynamic modelling and the interpretation of in vitro toxicity data. Toxicol. Lett. 120, 111-123.
3. Bond, J. A. (1989) Review of the toxicology of styrene. Crit. Rev. Toxicol. 19, 227-249.
4. van Duuren, B. L., Nelson, N., Orris, L., Palmes, E. D., and Schmitt, F. L. (1963) Cancerogenicity of epoxide, lactones and peroxyl compounds. J. Natl. Cancer Inst. 31, 41-55.
5. Barale, R. (1991) The genetic toxicology of styrene and styrene oxide. Mutat. Res. 257, 107-126.
6. IARC, International Agency for Research on Carcer (1994) Styrene-7,8-oxide. IARC Monogr. Eval. Carcinog. Risks Hum. 60, 321-346.
7. Cherry, N., and Gautrin, D. (1990) Neurotoxic effects of styrene: further evidence. Br. J. Ind. Med. 47, 29-37.
8. Pierce, C. H., Becker, C. E., Tozer, T. N., Owen, D. J., and So, Y. (1998) Modeling the acute neurotoxicity of styrene. J. Occup. Environ. Med. 40, 230-240.
9. Tornero-Velez, R., Waidyanatha, S., Licea Pérez, H., Osterman-Golkar, S., Echeverria, D., and Rappaport, S. M. (2001) Determination of styrene and styrene-7,8-oxide in human blood by gas chromatography-mass spectrometry. J. Chromatogr. B 757, 59-68.
10. Kezic, S., Jakasa, I., Wenker, M. A. M., Boogaard, P. J., Monster, A. C., and de Wolff, F. A. (2000) Gas chromatography-electron capture determination of styrene-7,8-oxide enantiomers. J. Chromatogr. B 749, 265-274.
11. 8-styrene vapors. Toxicol. Appl. Pharmacol. 168, 36-49.
12. Löf, A., Gullstrand, E., Lundgren, E., and Byfält Nordqvist, M. (1984) Occurrence of styrene-7,8-oxide and styrene glycol in mouse after the administration of styrene. Scand. J. Work Environ. Health 10, 179-187.
13. Mendrala, A. L., Langvart, P. W., Nitschke, K. D., Quast, J. F., and Nolan, R. J. (1993) In vitro kinetics of styrene and styrene oxide metabolism in rat, mouse and human. Arch. Toxicol. 67, 18-27.
14. Rouseff, R., and Cadwallader, K. (2001) Headspace techniques in foods, fragrances and flavours: an overview. Adv. Exp. Med. Biol. 448, 1-8.
15. de Fátima Alpendurada, M. (2000) Solid-phase micro-extraction: a promising technique for sample preparation in environmental analysis. J. Chromatogr. A 889, 3-14.
16. Ulrich, S. (2000) Solid-phase micro-extraction in biomedical analysis. J. Chromatogr. A 902, 167-194.
17. Theodoridis, G., Koster, E. H. M., and de Jong, G. J. (2000) Solid-phase micro-extraction for the analysis of biological samples. J. Chromatogr. B 745, 49-82.
18. Vaes, W. H., Ramos, E. U., Hamwijk, C., van Holsteijn, I., Blaauboer, B. J., Seinen, W., Verhaar, H. J., and Hermes, J. L. (1997) Solid-phase micro-extraction as a tool to determine membrane/water partition coefficients and bioavailable concentrations in in vitro systems. Chem. Res. Toxicol. 10, 1067-1072.
19. Darè, E., Tofighi, R., Vettori, M. V., Momoi, T., Poli, D., Saido, T., Mutti, A., and Ceccatelli, S. (2002) Styrene 7,8-oxide induces caspase activation and regular DNA fragmentation in neuronal cells. Brain Res. 933, 12-22.
20. Kohn, J., Minotti, S., and Durham, H. (1995) Assessment of the neurotoxicity of styrene, styrene oxide, and styrene glycol in primary cultures of motor and sensory neurons. Toxicol. Lett. 75, 29-37.
21. Ioffe, B. V., and Vitenberg, A. G. (1984) Headspace Analysis and Related Methods in Gas Chromatography, pp 61-62, Wiley-Interscience, New York.
22. Lin, B., and Whalen, D. L. (1994) Stereochemistry of the spontaneous, acid-catalyzed and base-catalyzed hydrolyses of styrene oxide. J. Org. Chem. 59, 1638-1641.