Thirteen-week repeated dose toxicity study of wormwood (Artemisia absinthium) extract in rats

Journal of Toxicological Sciences

Volumn 28, Issue 5, 2003, Pages 471-478

  Muto, Tomoko ^a   Watanabe, Takao ^a   Okamura, Miwa ^a   Moto, Mitsuyoshi ^a   Kashida, Yoko ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

Author keywords

Food additive; Rat; Wormwood

Indexed keywords

ARTEMISIA ABSINTHIUM EXTRACT; FOOD ADDITIVE; PLANT EXTRACT;

ABSINTHE; ANIMAL MODEL; ANIMAL TISSUE; ARTEMISIA; ARTEMISIA ABSINTHIUM; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FEMALE; FLUID INTAKE; FOOD INTAKE; FOOD SAFETY; HISTOPATHOLOGY; MALE; NONHUMAN; RAT; SURVIVAL RATE; TOXICITY TESTING;

ANIMALIA; ARTEMISIA; ARTEMISIA ABSINTHIUM;

EID: 1642554299     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.28.471     Document Type: Article

References (20)

1. Arnold, W.N. (1988): Vincent van Gogh and the thujone connection. J.A.M.A., 260, 3042-3044.
2. Brown, D. (1984): The Encyclopaedia of Herbs and Their Uses. Dorling Kindersley, London.
3. Chevallier, A. (1996): The Encyclopaedia of Medicinal Plants. Dorling Kindersley, London.
4. Del Castillo, J., Anderson, M. and Rubottom, G.M. (1975): Marijuana, absinthen and the central nervous system. Nature, 253, 365-366.
5. Dunnett, C.W. (1955): A multiple comparison procedure for comparing several treatments with a control. Amer. Statist. Assoc. J., 50, 1096-1121.
6. European Commission (2003): Opinion of the Scientific Committee on Food on Thujone. Health and Consumer Protection Directorate-general, Bruxelles/Brussel-Belgium.
7. Gharzouli, K., Khennouf, S., Amira, S. and Gharzouli, A. (1999): Effects of aqueous extracts from Quercus ilex L. root bark, Punica granatum L. fruit peel and Artemisia herba-alba Asso leaves on ethanol-induced gastric damage in rats. Phytother. Res., 13, 42-45.
8. Gilani, A.H. and Janbaz, K.H. (1995): Preventive and curative effects of Artemisia absinthium on acetaminophen and CC14-induced hepatotoxicity. Gen Pharmacol., 26, 309-315.
9. Grieve, M. (1931): A Modern Herbal. 1980 edition, PP.856-861, Penguin Books, London.
10. Hold, K.M., Sirisomas, S.I., Ikeda, T., Narahashi, T. and Casida, J.E. (2000): Alpha-thujone (the active component of absinthe): Gamma-aminobutyric acid type A receptor modulation and metabolic detoxification. Proc. Natl. Acad. Sci. USA, 97, 3826-3831.
11. Ikram, M., Khattak, S.G. and Gilani, S.N. (1985): Antipyretic studies on some indigenous Pakistani medicinal plants. J. Ethnopharmacol., 14, 45-51.
12. 4-induced liver damage. J. Ethnopharmacol., 47, 43-47.
13. John, S., Wilfred, A. and Timothy, P. (1999): Absinthe: What's your poison? Though absinthe is intriguing, it is alcohol in general we should worry about. Br. Med. J., 319, 1590-1592.
14. Lawrence, B.M. (1995): Natural Flavor and Fragrance Materials. "Perfumer & Flavorist". Essential Oils 1992-1994. Carol Stream, IL., Allured Publishing Corp., 11-14.
15. Meschler, J.P. and Howlett, A.C. (1999): Thujone exhibits low affinity for cannanioid receptor but fails to evoke cannabimimetic responses. Pharmacol. Biochem. Behav., 62, 473-480.
16. Olsen, R.W. (2000): Absinthe and gamma-aminobutyric acid receptors. Proc. Natl. Acad. Sci. USA, 97, 4417-4418.
17. Park, E.J., Nan, J.X., Kim, J.Y., Kang, H.C., Choi, J.H., Lee, S.J., Lee, B.H., Kim, S.J., Lee, J.H., Kim, Y.C. and Sohn, D.H. (2000): The ethanol-soluble part of a hot-water extract from Artemisia iwayomogi inhibits liver fibrosis induced by carbon tetrachloride in rats. J. Pharm. Pharmacol., 52, 875-881.
18. Pinto-Scognamiglio, W. (1968): Effects thujone on spontaneous activity and on conditioned behavior of rats. Boll. Chim. Farm., 107, 780-791.
19. 4-induced liver damage in rats. Arch. Pharm. Res., 21, 508-513.
20. Vogt, D.D. and Montagne, M. (1982): Absinthe: Behind the emerald mask. Intern. J. Addict. 17, 1015-1029.