Effects of radiation on fatty liver and metabolic coronary risk factors among atomic bomb survivors in Nagasaki

Hypertension Research

Volumn 26, Issue 12, 2003, Pages 965-970

  Akahoshi, Masazumi ^a   Amasaki, Yasuko ^a   Soda, Midori ^a   Hida, Ayumi ^a   Imaizumi, Misa ^a   Nakashima, Eiji ^a   Maeda, Renju ^a   Seto, Shinji ^b   Yano, Katsusuke ^b  

^a RADIATION EFFECTS RESEARCH FOUNDATION   (Japan)

^b NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Coronary disease; Epidemiology; Lipids; Liver

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID;

ADULT; AGED; ARTICLE; ATOMIC BOMB SURVIVOR; ATOMIC WARFARE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CORONARY RISK; ECHOGRAPHY; FATTY LIVER; FEMALE; GLUCOSE METABOLISM; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; ISCHEMIC HEART DISEASE; JAPAN; LOGISTIC REGRESSION ANALYSIS; MALE; METABOLIC SYNDROME X; OBESITY; PREVALENCE; RADIATION DOSE; RADIATION EXPOSURE; RISK FACTOR;

AGED; CORONARY DISEASE; CROSS-SECTIONAL STUDIES; FATTY LIVER; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; INSULIN RESISTANCE; JAPAN; MALE; MIDDLE AGED; NUCLEAR WARFARE; OBESITY; RADIATION DOSAGE; RISK FACTORS;

EID: 1642545077     PISSN: 09169636     EISSN: None     Source Type: Journal    
DOI: 10.1291/hypres.26.965     Document Type: Article

References (50)

1. Pierce DA, Shimizu Y, Preston DL, Vaeth M, Mabuchi K: Studies of the mortality of atomic bomb survivors: report 12, part I: cancer: 1950-1990. Radiat Res 1996; 146: 1-27.
2. Pierce DA, Preston DL: Radiation-related cancer risks at low doses among atomic bomb survivors. Radiat Res 2000; 154: 178-186.
3. Shigematsu I: The 2000 Sievert Lecture - lessons from atomic bomb survivors in Hiroshima and Nagasaki. Health Phys 2000; 79: 234-241.
4. Shimizu Y, Pierce DA, Preston DL, Mabuchi K: Studies of the mortality of atomic bomb survivors: report 12, part II: noncancer mortality: 1950-1990. Radiat Res 1999; 152: 374-389.
5. Wong FL, Yamada M, Sasaki H, et al: Noncancer disease incidence in the atomic bomb survivors: 1958-1986. Radiat Res 1993; 135: 418-430.
6. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S: Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 1987; 36: 54-59.
7. Nakamura T, Tokunaga K, Shimomura I, et al: Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis 1994; 107: 239-246.
8. Kanai H, Matsuzawa Y, Kotani K, et al: Close correlation of intra-abdominal fat accumulation to hypertension in obese women. Hypertension 1990; 16: 484-490.
9. Meigs JB, D'Agostino RB Sr, Wilson PW, Cupples LA, Nathan DM, Singer DE: Risk variable clustering in the insulin resistance syndrome: the Framingham Offspring Study. Diabetes 1997; 46: 1594-1600.
10. Edwards KL, Burchfiel CM, Sharp DS, et al: Factors of the insulin resistance syndrome in nondiabetic and diabetic elderly Japanese-American men. Am J Epidemiol 1998; 147: 441-447.
11. Sakkinen PA, Wahl P, Cushman M, Lewis MR, Tracy RP: Clustering of procoagulation, inflammation, and fibrinolysis variables with metabolic factors in insulin resistance syndrome. Am J Epidemiol 2000; 152: 897-907.
12. Rexrode KM, Carey VJ, Hennekens CH, et al: Abdominal adiposity and coronary heart disease in women. JAMA 1998; 280: 1843-1848.
13. Lempiainen P, Mykkanen L, Pyorala K, Laakso M, Kuusisto J: Insulin resistance syndrome predicts coronary heart disease events in elderly nondiabetic men. Circulation 1999; 100: 123-128.
14. Ruige JB, Assendelft WJ, Dekker JM, Kostense PJ, Heine RJ, Bouter LM: Insulin and risk of cardiovascular disease: a meta-analysis. Circulation 1998; 97: 996-1001.
15. Marceau P, Biron S, Hould FS, et al: Liver pathology and the metabolic syndrome X in severe obesity. J Clin Endocrinol Metab 1999; 84: 1513-1517.
16. Banerji MA, Buckley MC, Chaiken RL, Gordon D, Lebovitz HE, Kral JG: Liver fat, serum triglycerides and visceral adipose tissue in insulin-sensitive and insulin-resistant black men with NIDDM. Int J Obes Relat Metab Disord 1995; 19: 846-850.
17. Akahoshi M, Amasaki Y, Soda M, et al: Correlation between fatty liver and coronary risk factors: a population study of elderly men and women in Nagasaki, Japan. Hypertens Res 2001; 24: 337-343.
18. Atomic Bomb Casualty Commission: Research Plan for Joint ABCC-NIH Adult Health Study in Hiroshima and Nagasaki, Atomic Bomb Casualty Commission Technical Report. Hiroshima, Atomic Bomb Casualty Commission, 1962, 11-62.
19. Yajima Y, Ohta K, Narui T, Abe R, Suzuki H, Ohtsuki M: Ultrasonographical diagnosis of fatty liver: significance of the liver-kidney contrast. Tohoku J Exp Med 1983; 139: 43-50.
20. Scatarige JC, Scott WW, Donovan PJ, Siegelman SS, Sanders RC: Fatty infiltration of the liver: ultrasonographic and computed tomographic correlation. J Ultrasound Med 1984; 3: 9-14.
21. Japanese Hypertension Society Guidelines Subcommittee for the Management of Hypertension: Guidelines for the management of hypertension for general practitioners. Hypertens Res 2001; 24: 613-634.
22. Ikeda Y, Ohno M: Definition, classification and judgement of obesity, and clinical diagnosis of obesity as disease. Nippon Rinsho 1995; 53 (Suppl): 229-236.
23. Japan Atherosclerosis Society: Japan Atherosclerosis Society (JAS) Guidelines for Diagnosis and Treatment of Atherosclerotic Cardiovascular Diseases, Vol. 1. Tokyo, Japan Atherosclerosis Society, 2002 (in Japanese).
24. MaClullagh P, Nelder J: Generalized Linear Models, Second ed. London, Chapman and Hall, 1989.
25. W. Roesch: U.S.-Japan Joint Reassessment of Atomic Bomb Radiation Dosimetry in Hiroshima and Nagasaki-Final Report, Vol. 1. Hiroshima, Radiation Effects Research Foundation, 1987.
26. Bjorntorp P: "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes. Arteriosclerosis 1990; 10: 493-496.
27. Kral JG, Lundholm K, Bjorntorp P, Sjostrom L, Schersten T: Hepatic lipid metabolism in severe human obesity. Metabolism 1977; 26: 1025-1031.
28. Svedberg J, Bjorntorp P, Smith U, Lonnroth P: Free-fatty acid inhibition of insulin binding, degradation, and action in isolated rat hepatocytes. Diabetes 1990; 39: 570-574.
29. Despres JP: Dyslipidaemia and obesity. Baillieres Clin Endocrinol Metab 1994; 8: 629-660.
30. Laakso M: Insulin resistance and coronary heart disease. Curr Opin Lipidol 1996; 7: 217-226.
31. James O, Day C: Non-alcoholic steatohepatitis: another disease of affluence. Lancet 1999; 353: 1634-1636.
32. Pekkanen J, Linn S, Heiss G, et al: Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease. N Engl J Med 1990; 322: 1700-1707.
33. Goldbourt U, Yaari S, Medalie JH: Isolated low HDL cholesterol as a risk factor for coronary heart disease mortality: a 21-year follow-up of 8000 men. Arterioscler Thromb Vasc Biol 1997; 17: 107-113.
34. Cullen P: Evidence that triglycerides are an independent coronary heart disease risk factor. Am J Cardiol 2000; 86: 943-949.
35. Austin MA: Epidemiology of hypertriglyceridemia and cardiovascular disease. Am J Cardiol 1999; 83: 13F-16F.
36. Ballantyne CM, Grundy SM, Oberman A, et al: Hyperlipidemia: diagnostic and therapeutic perspectives. J Clin Endocrinol Metab 2000; 85: 2089-2112.
37. Manninen V, Tenkanen L, Koskinen P, et al: Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study: implications for treatment. Circulation 1992; 85: 37-45.
38. Assmann G, Schulte H: Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience): Prospective Cardiovascular Munster study. Am J Cardiol 1992; 70: 733-737.
39. Grundy SM: Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 1999; 83: 25F-29F.
40. Akahoshi M, Soda M, Nakashima E, et al: The effects of body mass index on age at menopause. Int J Obes Relat Metab Disord 2002; 26: 961-968.
41. Rizvi RY, Johri SK, Ali R: Changes in cholesterol and phospholipids level of albino rats following whole body gamma irradiation with sublethal doses. J Radiat Res (Tokyo) 1984; 25: 85-90.
42. Stepanov SA: Lipid metabolic changes in rats with radiation sickness and a pronounced intestinal syndrome following the local irradiation of the abdominal area: the total lipid content of the blood serum and tissues. Radiobiologiia 1989; 29: 179-182.
43. Wong FL, Yamada M, Sasaki H, Kodama K, Hosoda Y: Effects of radiation on the longitudinal trends of total serum cholesterol levels in the atomic bomb survivors. Radiat Res 1999; 151: 736-746.
44. Sawada H, Kodama K, Shimizu Y, Kato H: Adult Health Study Report 6, Results of Six Examination Cycles, 1968-80, Hiroshima and Nagasaki. Hiroshima, Radiation Effects Research Foundation, TR 3-86, 1986.
45. Ito C, Hasegawa K, Kato M, Kumazawa T: Clinical investigation of proximately exposed group: a study of the prevalence rate of diabetes mellitus. J Nagasaki Med Assoc 1984; 59: 349-355.
46. Williams LB, Fawcett RL, Waechter AS, et al: Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender. J Clin Endocrinol Metab 2000; 85: 2678-2684.
47. Mantzoros CS: The role of leptin in human obesity and disease: a review of current evidence. Ann Intern Med 1999; 130: 671-680.
48. Shimomura I, Funahashi T, Takahashi M, et al: Enhanced expression of PAI-1 in visceral fat: possible contributor to vascular disease in obesity. Nat Med 1996; 2: 800-803.
49. Hotamisligil GS: The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med 1999; 245: 621-625.
50. Miles PD, Barak Y, He W, Evans RM, Olefsky JM: Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J Clin Invest 2000; 105: 287-292.