Decreased Expression of Transforming Growth Factor-β II Receptor Is Associated with That of p27KIP1 in Giant Cell Tumor of Bone: A Possible Link between Transforming Growth Factor-β and Cell Cycle-Related Protein

Human Pathology

Volumn 35, Issue 1, 2004, Pages 61-68

  Kawaguchi, Ken Ichi ^b   Oda, Yoshinao ^a   Saito, Tsuyoshi ^b   Yamamoto, Hidetaka ^b   Takahira, Tomonari ^b   Tamiya, Sadafumi ^b   Iwamoto, Yukihide ^b   Tsuneyoshi, Masazumi ^b  

^a KYUSHU UNIVERSITY   (Japan)

^b NONE

Author keywords

Giant cell tumor of bone; P27; Transforming growth factor II receptor; Transforming growth factor 1

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; PROTEIN; PROTEIN P27; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA1 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA2 RECEPTOR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; BONE TUMOR; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; CORRELATION ANALYSIS; FEMALE; GIANT CELL TUMOR; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LABELING INDEX; MAJOR CLINICAL STUDY; MALE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SCHOOL CHILD; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 1642539994     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2003.07.004     Document Type: Article

References (33)

1. Doussis IA, Puddle B, Athanasou NA: Immunophenotype of multinucleated and mononuclear cells in giant cell lesions of bone and soft tisue. J Clin Pathol 45:398-404, 1992
2. Goldring SR, Roelke MS, Perrison KK, et al: Human giant cell tumors of bone: Identification and characterization of cell types. J Clin Invest 79:483-491, 1987
3. Athanasou NA, Bliss E, Gatter KC, et al: An immunohistological study of giant cell tumor of bone: Evidence for an osteoclast origin of the giant cells. J Pathol 147:153-158, 1985
4. Laiho M, Weis FM, Boyd FT, et al: Responsiveness to transforming growth factor-beta (TGF-β) restored by genetic complementation between cells defective in TGF-β receptors I and II. J Biol Chem 266:9108-9112, 1991
5. Paterson IC, Matthews JB, Huntley S, et al: Decreased expression of TGF-β cell surface receptors during progression of human oral squamous cell carcinoma. J Pathol 193:458-467, 2001
6. Williams RH, Stapleton AMF, Yang G, et al: Reduced levels of transforming growth factor-β receptor type II in human prostate cancer: an immunohistochemical study. Clin Can Res 2:635-640, 1996
7. Polyak K, Lee MH, Erdjument-Bromage H, et al: Cloning of p27KIP1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Cell 78:59-66, 1994
8. Ewen ME, Sluss HK, Whitehouse LL, et al: TGF-β inhibition of cdk4 synthesis is linked to cell cycle arrest. Cell 74:1009-1020, 1993
9. Datto MB, Li Y, Panus JF, et al: Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc Natl Acad Sci U S A 92:5545-5549, 1995
10. Polyak K, Kato M, Solomon MJ, et al: p27KIP1, a cyclin-Cdk inhibitor, links transforming growth factor-β and contact inhibition to cell cycle arrest. Genes Dev 160:770-777, 1998
11. Zheng MH, Fan Y, Wysocki SJ, et al: Gene expression of transforming growth factor-β1 and its type II receptor in giant cell tumors of bone: Possible involvement in osteoclast-like cell migration. Am J Pathol 145:1095-1104, 1994
12. Enneking WF: Staging of musculoskeletal tumors, in Enneking WF (ed): Musculoskeletal Tumor Surgery. New York, Churchill Livingstone, 1983, pp 69-88
13. Gobbi H, Dupont WD, Simpson JF, et al: Transforming growth factor-beta and breast cancer risk in women with mammary epithelial hyperplasia. J Natl Cancer Inst 91:2096-2101, 1999
14. Franchi A, Arganini L, Baroni G, et al: Expression of transforming growth factor beta isoforms in osteosarcoma variants: Association of TGF-β1 with high-grade osteosarcomas. J Pathol 185:284-289, 1998
15. Feakins RM, Mulcahy HE, Quaglia A, et al: p27Kip loss dose not predict survival in patients with advanced gastric carcinoma. Cancer 89:1684-1691, 2000
16. Cheng L, Lloyd RV, Weaver AL, et al: The cell cycle inhibitors p21 WAF1 and p27 KIP1 are associated with survival in patients treated by salvage prostatectomy after radiation therapy. Clin Cancer Res 6:1896-1899, 2000
17. Wulling M, Engels C, Jesse N, et al: The nature of giant cell tumor of bone. J Cancer Res Clin Oncol 127:467-474, 2001
18. Dahlin DC, Cupps RE, Johnson EW: Giant cell tumours: A study of 195 cases. Cancer 25:1061-1070, 1970
19. Huvos AG: Benign giant cell tumour of bone. HUM PATHOL 12:1151, 1981
20. Liu TC, Ji ZM, Wang LT: Giant cell tumours of bone: An immunohistochemical study. Pathol Res Pract 185:448-453, 1989
21. Ueda Y, Imai K, Tsuchiya H, et al: Matrix metalloproteinase 9 (gelatinase B) is expressed in multinucleated giant cells of human giant cell tumor of bone and is associated with vascular invasion. Am J Pathol 148:611-622, 1996
22. Zheng MH, Xu MJ, Robbins P, et al: Gene expression of vascular endothelial growth factor in giant cell tumor of bone. HUM PATHOL 31:804-812, 2000
23. Ferracini R, Scotlandi K, Cagliero E, et al: The expression of Met/hepatocyto growth factor receptor gene in giant cell tumors of bone and other benign musculoskeletal tumors. J Cell Physiol 184: 191-196, 2000
24. Motokura T, Arnold A: Cyclin D and oncogenesis. Curr Opin Genet Dev 3:5-10, 1993
25. Hunter T, Pines J: Cyclins and cancer. Cyclin D and CDK inhibitors come of age. Cell 79:573-582, 1994
26. Teot LA, O'Keefe RJ, Rosier RN, et al: Extraosseous primary and recurrent giant cell tumors: Transforming growth factor-β1 and-β2 expression may explain metaplastic bone formation. HUM PATHOL 27:625-632, 1996
27. Fredersdorf S, Burns J, Milne AM, et al: High-level expression of p27KIP1 and cyclin D in some human breast cancer cells: Inverse correlation between the expression of p27KIP1 and degree of malignancy in human breast and colorectal cancers. Proc Nat Acad Sci U S A 94:6380-6385, 1997
28. Xiangming C, Natsugoe S, Takao S, et al: The cooperative role of p27 with cyclin E in the prognosis of advanced gastric carcinoma. Cancer 89:1214-1219, 2000
29. Kourea HP, Cardon-Cardo C, Dudas M, et al: Expression of p27KIP1 and other cell cycle regulators in malignant peripheral nerve sheath tumors and neurofibromas: The emerging role of p27KIP in malignant transformation of neurofibroma. Am J Pathol 155:1885-1891, 1999
30. Guo Y, Jacobs SC, Kyprianou N: Down-regulation of protein and mRNA expression for transforming growth factor-beta (TGF-β1) type I and type II receptors in human prostate cancer. Int J Cancer 71:573-579, 1997
31. Derynck R, Zhang Y, Feng XH: Smads: Transcriptional activators of TGF-β responses. Cell 95:737-740, 1998
32. Massague J: TGF-β signal transduction. Annu Rev Biochem 67:753-791, 1998
33. Lagna G, Hata A, Massague J: Partnership between DPC4 and SMAD protein in TGF-β signaling pathway. Nature 383:832-836, 1996